Continuous Photoacoustic Monitoring of Neonatal Stroke in Intensive Care Unit

重症监护病房新生儿中风的连续光声监测

基本信息

  • 批准号:
    10548689
  • 负责人:
  • 金额:
    $ 34.45万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-02 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Neonatal encephalopathy can arise from fetal hypoxia-ischemia during labor, chronic uteroplacental inflammation, and large cerebral artery embolization primarily arising from dislodgement of a placental thrombus. Because of overlapping clinical presentation, differential diagnosis is often delayed until seizures develop and MRI can be safely performed, a time at which most neuroprotectants are ineffective. Whereas hypothermia is approved for use within 6 hours of birth for hypoxia-ischemia, no treatments have been approved for perinatal arterial ischemic stroke because of the difficulty of definitive diagnosis required for clinical trial stratification at birth. With an estimated incidence of 17-93 per 100,000 live births, the incidence of stroke in the perinatal period rivals the incidence of stroke in adults (17-23 per 100,000). Therefore, a device that could rapidly and reliably identify an area of focal cerebral ischemia soon after birth would have a major impact by enabling the testing of neuroprotectants at an early therapeutic time window that would maximize efficacy. The Brimrose Technology Corporation, partnering with Johns Hopkins University, propose a photoacoustic helmet (PAH) device that can be safely deployed at the bedside in the neonatal intensive care unit to 1) continuously monitor and rapidly identify at-risk neonates, shortly after birth, rapidly allowing them to be triaged to therapy; 2) monitor the progress of therapy; and 3) provide prognostic information to the parents of newborns at risk for life-long brain injury. The PA imaging mechanism is a purely hybrid mechanism, providing rich optical absorbance contrast of tissue oxy- and deoxyhemoglobin through intact scalp and skull. A proof-of-concept of detecting decreased tissue oxyhemoglobin in a 1 cm-induced experimental stroke has been demonstrated with standard laboratory PA laser light source and clinical ultrasound detector. Our goal is to incorporate safer light-emitting diodes (LEDs) and more sensitive ultrasound detectors configured in a neonatal helmet to localize cortical regions of low oxygenation in the newborn. In the proposed Phase-I STTR, we will develop fundamental hardware and software components for effective integration. Aim 1 - Software for safe PAH imaging at high contrast resolution, including deep neural network and optimal spectral unmixing techniques to enable a safe and high-speed LED-based PAH system. Aim 2 - Hardware for modular PAH system, including a fiber-coupled Brimrose ultra-sensitive multi- bounce laser microphone and optimal modular unit design for a PAH imaging at high spatial-temporal-spectral resolution through intact scalp and skull. Aim 3 - Framework for modular PAH system integration, enabling a robust integration of modular units in a PAH system with rigid-body tag registration using optical tracking, in which different neonatal head shapes and need for different imaging specifications can be accommodated. The Phase-I milestone is detection of the full blood O2 saturation range at <10 mm full-width-half-maximum in the transverse plane and 5 mm sensing depth through ex vivo neonatal piglet skull + scalp sample with an integrated set of hardware and software packages, allowing preclinical validation studies to proceed in Phase II.
项目摘要/摘要 新生儿脑病可由分娩时胎儿缺氧缺血、慢性子宫胎盘炎、 炎症和主要由胎盘血栓移位引起的大脑动脉栓塞。 由于重叠的临床表现,鉴别诊断往往被推迟,直到癫痫发作的发展, MRI可以安全地进行,此时大多数神经保护剂无效。而体温过低 批准在出生后6小时内用于缺氧缺血,尚未批准用于围产期 动脉缺血性卒中,因为临床试验分层需要明确诊断, 出生估计发病率为每100,000例活产17-93例,围产期中风发病率 与成人中风发病率(17-23/100,000)相当。因此,一种可以快速可靠地 在出生后不久确定一个局灶性脑缺血区域将产生重大影响, 在早期的治疗时间窗口,神经保护剂将最大限度地提高疗效。Brimrose技术 公司与约翰霍普金斯大学合作,提出了一种光声头盔(PAH)设备, 安全地部署在新生儿重症监护病房的床边,以1)连续监测和快速监测 在新生儿出生后不久就识别出高危新生儿,迅速将其分类治疗; 2)监测进展情况 3)为有终身脑损伤风险的新生儿父母提供预后信息。的 PA成像机制是一种纯混合机制,提供了组织氧合物的丰富的光吸收对比度。 和脱氧血红蛋白的混合物检测组织减少的概念验证 用标准实验室PA激光已经证明了在1cm诱导的实验性中风中的氧合血红蛋白 光源和临床超声探测器。我们的目标是采用更安全的发光二极管(LED), 在新生儿头盔中配置更灵敏的超声检测器,以定位低密度皮质区域, 新生儿的氧合。在拟议的第一阶段STTR中,我们将开发基本硬件和软件 有效整合的组成部分。目标1 -用于高对比度分辨率下安全PAH成像的软件,包括 深度神经网络和最佳光谱分解技术,以实现安全和高速的LED PAH 系统目标2 -模块化PAH系统的硬件,包括光纤耦合Brimrose超灵敏多功能 用于高时空谱下PAH成像的反射激光麦克风和最佳模块化单元设计 通过完整的头皮和头骨的分辨率。目标3 -模块化PAH系统集成框架, PAH系统中的模块化单元与使用光学跟踪的刚体标签配准的鲁棒集成, 其可以适应不同的新生儿头部形状和对不同成像规格的需要。的 第一阶段的里程碑是在<10 mm的半高全宽处检测到全血氧饱和度范围, 横向平面和5 mm传感深度通过离体新生仔猪颅骨+头皮样品, 一套硬件和软件包,允许在第二阶段进行临床前验证研究。

项目成果

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Emad M Boctor其他文献

Photoacoustic Emission Efficiency of Polymer Matrix Nanocomposites for Use in Epiretinal Prosthetics*
用于视网膜前假体的聚合物基质纳米复合材料的光声发射效率*

Emad M Boctor的其他文献

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{{ truncateString('Emad M Boctor', 18)}}的其他基金

5T-IV: photoacoustic needle with beacon pulse for ultrasound guided vascular access with Tool-Tip Tracking and Tissue Typing
5T-IV:带有信标脉冲的光声针,用于通过工具提示跟踪和组织分型进行超声引导血管通路
  • 批准号:
    10677283
  • 财政年份:
    2023
  • 资助金额:
    $ 34.45万
  • 项目类别:
A Normal Paradigm to Monitor Perinatal Asphyxia Using A Combined Ultrasound-Neuromodulation and Photoacoustic-Imaging Device
使用超声神经调节和光声成像相结合的设备监测围产期窒息的正常范例
  • 批准号:
    10552231
  • 财政年份:
    2022
  • 资助金额:
    $ 34.45万
  • 项目类别:
Development of real-time, non-invasive photoacoustic imaging to rapidly detect and track perinatal focal stroke at birth
开发实时、非侵入性光声成像,以快速检测和跟踪出生时的围产期局灶性中风
  • 批准号:
    10063016
  • 财政年份:
    2017
  • 资助金额:
    $ 34.45万
  • 项目类别:
Prostate Specific Membrane Antigen Targeted Photoacoustic Imaging for Prostate Cancer
前列腺特异性膜抗原靶向光声成像治疗前列腺癌
  • 批准号:
    9178205
  • 财政年份:
    2016
  • 资助金额:
    $ 34.45万
  • 项目类别:
Prostate Specific Membrane Antigen Targeted Photoacoustic Imaging for Prostate Cancer
前列腺特异性膜抗原靶向光声成像治疗前列腺癌
  • 批准号:
    9279084
  • 财政年份:
    2016
  • 资助金额:
    $ 34.45万
  • 项目类别:
Interventional PhotoAcoustic Surgical System (i-PASS)
介入光声手术系统 (i-PASS)
  • 批准号:
    8509922
  • 财政年份:
    2013
  • 资助金额:
    $ 34.45万
  • 项目类别:
Integrated Photoacoustic Ultrasound Real-time Imaging for Brachytherapy Treatment
用于近距离放射治疗的集成光声超声实时成像
  • 批准号:
    8593128
  • 财政年份:
    2013
  • 资助金额:
    $ 34.45万
  • 项目类别:
Interventional PhotoAcoustic Surgical System (i-PASS)
介入光声手术系统 (i-PASS)
  • 批准号:
    8636019
  • 财政年份:
    2013
  • 资助金额:
    $ 34.45万
  • 项目类别:

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