Continuous Photoacoustic Monitoring of Neonatal Stroke in Intensive Care Unit

重症监护病房新生儿中风的连续光声监测

基本信息

  • 批准号:
    10548689
  • 负责人:
  • 金额:
    $ 34.45万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-02 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Neonatal encephalopathy can arise from fetal hypoxia-ischemia during labor, chronic uteroplacental inflammation, and large cerebral artery embolization primarily arising from dislodgement of a placental thrombus. Because of overlapping clinical presentation, differential diagnosis is often delayed until seizures develop and MRI can be safely performed, a time at which most neuroprotectants are ineffective. Whereas hypothermia is approved for use within 6 hours of birth for hypoxia-ischemia, no treatments have been approved for perinatal arterial ischemic stroke because of the difficulty of definitive diagnosis required for clinical trial stratification at birth. With an estimated incidence of 17-93 per 100,000 live births, the incidence of stroke in the perinatal period rivals the incidence of stroke in adults (17-23 per 100,000). Therefore, a device that could rapidly and reliably identify an area of focal cerebral ischemia soon after birth would have a major impact by enabling the testing of neuroprotectants at an early therapeutic time window that would maximize efficacy. The Brimrose Technology Corporation, partnering with Johns Hopkins University, propose a photoacoustic helmet (PAH) device that can be safely deployed at the bedside in the neonatal intensive care unit to 1) continuously monitor and rapidly identify at-risk neonates, shortly after birth, rapidly allowing them to be triaged to therapy; 2) monitor the progress of therapy; and 3) provide prognostic information to the parents of newborns at risk for life-long brain injury. The PA imaging mechanism is a purely hybrid mechanism, providing rich optical absorbance contrast of tissue oxy- and deoxyhemoglobin through intact scalp and skull. A proof-of-concept of detecting decreased tissue oxyhemoglobin in a 1 cm-induced experimental stroke has been demonstrated with standard laboratory PA laser light source and clinical ultrasound detector. Our goal is to incorporate safer light-emitting diodes (LEDs) and more sensitive ultrasound detectors configured in a neonatal helmet to localize cortical regions of low oxygenation in the newborn. In the proposed Phase-I STTR, we will develop fundamental hardware and software components for effective integration. Aim 1 - Software for safe PAH imaging at high contrast resolution, including deep neural network and optimal spectral unmixing techniques to enable a safe and high-speed LED-based PAH system. Aim 2 - Hardware for modular PAH system, including a fiber-coupled Brimrose ultra-sensitive multi- bounce laser microphone and optimal modular unit design for a PAH imaging at high spatial-temporal-spectral resolution through intact scalp and skull. Aim 3 - Framework for modular PAH system integration, enabling a robust integration of modular units in a PAH system with rigid-body tag registration using optical tracking, in which different neonatal head shapes and need for different imaging specifications can be accommodated. The Phase-I milestone is detection of the full blood O2 saturation range at <10 mm full-width-half-maximum in the transverse plane and 5 mm sensing depth through ex vivo neonatal piglet skull + scalp sample with an integrated set of hardware and software packages, allowing preclinical validation studies to proceed in Phase II.
项目摘要/摘要 新生儿脑病可由分娩过程中胎儿缺氧缺血、慢性子宫胎盘 炎症和主要由胎盘血栓移位引起的大脑大动脉栓塞术。 由于重叠的临床表现,鉴别诊断通常被推迟到癫痫发作和 核磁共振可以安全地进行,在这个时候大多数神经保护剂都是无效的。而体温过低则是 被批准在出生后6小时内用于缺氧缺血,还没有被批准用于围产期的治疗 动脉缺血性卒中,因为临床试验分层所需的确诊诊断困难。 出生。据估计,每10万名活产儿中有17-93人发生中风,围产期中风的发生率 与成年人的中风发病率(每10万人中有17-23人)不相上下。因此,一种可以快速而可靠地 在出生后不久识别局灶性脑缺血区域将产生重大影响,因为它能够测试 在早期治疗时间窗使用神经保护剂,以最大限度地提高疗效。樱草花技术 该公司与约翰·霍普金斯大学合作,提出了一种光声头盔(PAH)设备,它可以 安全地部署在新生儿重症监护病房的床边,以1)持续快速地进行监测 在出生后不久识别高危新生儿,迅速对他们进行分诊治疗;2)监测进展情况 以及3)向面临终身脑损伤风险的新生儿的父母提供预后信息。这个 PA成像机制是一种纯粹的混合机制,提供了组织氧的丰富的光吸收对比度。 和脱氧血红蛋白穿过完整的头皮和头骨。一种检测组织减少的概念验证 用实验室标准PA激光证实了1厘米诱发的实验性中风中的氧合血红蛋白。 光源和临床超声探测仪。我们的目标是整合更安全的发光二极管(LED)和 配置在新生儿头盔中的更灵敏的超声探测器,以定位低血压的皮质区域 新生儿的氧合作用。在拟议的第一阶段技术转让计划中,我们将开发基本的硬件和软件 有效集成的组件。目标1-用于高对比度分辨率的安全PAH成像的软件,包括 深度神经网络和最佳光谱分解技术实现基于LED的安全高速PAH 系统。AIM 2-模块化多环芳烃系统的硬件,包括光纤耦合的BrimRose超灵敏多通道 弹跳激光传声器与高时空光谱PAH成像模块的优化设计 通过完整的头皮和头骨进行分解。AIM 3-模块化PAH系统集成框架,支持 PAH系统中的模块单元与使用光学跟踪的刚体标签配准的强健集成 可以适应不同的新生儿头部形状和不同成像规格的需求。这个 第一阶段的里程碑是检测全血氧饱和度范围在&lt;10 mm全宽-半最大值在 通过体外新生仔猪头骨+头皮标本的横向平面和5 mm传感深度 一套硬件和软件包,允许在第二阶段进行临床前验证研究。

项目成果

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Emad M Boctor其他文献

Photoacoustic Emission Efficiency of Polymer Matrix Nanocomposites for Use in Epiretinal Prosthetics*
用于视网膜前假体的聚合物基质纳米复合材料的光声发射效率*

Emad M Boctor的其他文献

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{{ truncateString('Emad M Boctor', 18)}}的其他基金

5T-IV: photoacoustic needle with beacon pulse for ultrasound guided vascular access with Tool-Tip Tracking and Tissue Typing
5T-IV:带有信标脉冲的光声针,用于通过工具提示跟踪和组织分型进行超声引导血管通路
  • 批准号:
    10677283
  • 财政年份:
    2023
  • 资助金额:
    $ 34.45万
  • 项目类别:
A Normal Paradigm to Monitor Perinatal Asphyxia Using A Combined Ultrasound-Neuromodulation and Photoacoustic-Imaging Device
使用超声神经调节和光声成像相结合的设备监测围产期窒息的正常范例
  • 批准号:
    10552231
  • 财政年份:
    2022
  • 资助金额:
    $ 34.45万
  • 项目类别:
Development of real-time, non-invasive photoacoustic imaging to rapidly detect and track perinatal focal stroke at birth
开发实时、非侵入性光声成像,以快速检测和跟踪出生时的围产期局灶性中风
  • 批准号:
    10063016
  • 财政年份:
    2017
  • 资助金额:
    $ 34.45万
  • 项目类别:
Prostate Specific Membrane Antigen Targeted Photoacoustic Imaging for Prostate Cancer
前列腺特异性膜抗原靶向光声成像治疗前列腺癌
  • 批准号:
    9178205
  • 财政年份:
    2016
  • 资助金额:
    $ 34.45万
  • 项目类别:
Prostate Specific Membrane Antigen Targeted Photoacoustic Imaging for Prostate Cancer
前列腺特异性膜抗原靶向光声成像治疗前列腺癌
  • 批准号:
    9279084
  • 财政年份:
    2016
  • 资助金额:
    $ 34.45万
  • 项目类别:
Interventional PhotoAcoustic Surgical System (i-PASS)
介入光声手术系统 (i-PASS)
  • 批准号:
    8509922
  • 财政年份:
    2013
  • 资助金额:
    $ 34.45万
  • 项目类别:
Integrated Photoacoustic Ultrasound Real-time Imaging for Brachytherapy Treatment
用于近距离放射治疗的集成光声超声实时成像
  • 批准号:
    8593128
  • 财政年份:
    2013
  • 资助金额:
    $ 34.45万
  • 项目类别:
Interventional PhotoAcoustic Surgical System (i-PASS)
介入光声手术系统 (i-PASS)
  • 批准号:
    8636019
  • 财政年份:
    2013
  • 资助金额:
    $ 34.45万
  • 项目类别:

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