Verification of successful functionalisation of low cost test strips with biological molecules

为了开发新一代传感器，使低成本和易于使用的诊断产品得以实现，有必要高度详细地了解传感器条的表面属性。这是因为为了检测样本中的目标，有必要将生物分子附着到传感器表面。例如，可以将酶、抗体和DNA分子附着在传感器条上，以便从临床样本中检测生物标志物。目前，我们能否成功地将生物分子附着在表面上，阻碍了生物传感器在薄膜金和碳测试条上的发展。此外，确保表面清洁并准备好接受生物分子是这项研究工作的第二个挑战。本项目将专注于通过测量低成本传感器表面的粗糙度和成分来发展对其基本的理解，然后研究与大批量制造兼容的表面清洁方法，最后研究将生物分子附着到传感器表面的化学方法。在项目结束时，该公司将在传感器清洁和生物分子附着领域获得许多知识，这些知识可以应用于它打算创造的新诊断产品。

To develop next generation sensors which allow low cost and easy to use diagnostic products to be realised, it is necessary to understand the surface properties of the sensor strips in high detail. This is because it is necessary to attach biological molecules to the sensor surface in order to detect a target in a sample. For example, enzymes, antibodies and DNA molecules can be attached to the sensor strip in order to detect biomarkers from a clinical samples.At present, the development of biosensors on thin film gold and carbon test strips is hindered by our ability to successfully attach biological molecules to the surface. Furthermore, ensuring the surface is clean and ready to accept the biological molecules is a second challenge which underpins this research effort.This project will focus on developing the fundamental understanding of the low cost sensor surfaces through measuring their roughness and composition and then investigating methods to clean the surfaces which are compatible with high volume manufacturing and finally examine chemical methods for attaching biological molecules to the sensor surface. At the end off the project, the company will have gained a lot of knowledge in the areas of sensor cleaning and biomolecule attachment which it can apply to the new diagnostic products which it intends to create.