Discovery and optimisation of unconventional yeasts to enable the industrial scaling of alternative protein production using precision fermentation

非常规酵母的发现和优化，以实现利用精密发酵实现替代蛋白质生产的工业规模化

• 批准号: 10074091
• 金额: $ 6.31万
• 依托单位: HERLAB LTD
• 依托单位国家: 英国
• 项目类别: Grant for R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10074091
• 关键词: Discovery; optimisation; unconventional; yeasts; enable

Our food system is facing challenges that require innovative solutions. One emerging solution is alternative proteins, which have the potential to reduce the environmental, ethical, and health impacts of animal agriculture. However, to be a viable alternative, these proteins must achieve taste and price parity with conventional animal-based products.Our innovative yeast technology is designed to meet this challenge. We're using cutting-edge synthetic biology and machine learning tools to identify and develop next-generation yeast strains that are highly efficient and scalable for industrial-scale protein production.Our project focuses on demonstrating the viability of this approach by focusing on two of the most promising species identified by us in the lead-up to this project. Our goal is to use them to produce two biomolecules of economical and environmental significance in food production. If successful, this proof of concept will validate the promise of our yeast screening platform, unlocking the possibility for developing multiple next-generation yeast strains for a more sustainable and more affordable food, cosmetics, and even pharmaceutical ingredient production. Moreover, our approach carries broader implications for the biotechnology industry, as our unique yeast screening platform bears a transformative value for a wide range of active applications.Our innovative approach to sustainable protein production will have a significant positive impact on the environment, public health, and the economy. By reducing dependence on animal agriculture and petroleum-derived ingredients, we can create more sustainable food and health systems that benefit our society.

我们的食品体系正面临挑战，需要创新的解决方案。一种新兴的解决方案是替代蛋白质，它有可能减少畜牧业对环境、道德和健康的影响。然而，要成为一种可行的替代品，这些蛋白质必须达到与传统动物性产品同等的口味和价格。我们的创新酵母技术旨在应对这一挑战。我们正在使用最先进的合成生物学和机器学习工具来识别和开发下一代酵母菌株，这些酵母菌株高效且可扩展，可用于工业规模的蛋白质生产。我们的项目重点是通过关注我们在该项目之前确定的两种最有前途的物种来证明这种方法的可行性。我们的目标是利用它们生产两种在食品生产中具有经济和环境意义的生物分子。如果成功，这一概念验证将验证我们酵母筛选平台的承诺，从而为开发多种下一代酵母菌株提供可能性，以实现更可持续、更经济的食品、化妆品甚至药物成分生产。此外，我们的方法对生物技术行业具有更广泛的影响，因为我们独特的酵母筛选平台对广泛的积极应用具有变革性价值。我们可持续蛋白质生产的创新方法将对环境、公共健康和经济产生重大的积极影响。通过减少对畜牧业和石油衍生成分的依赖，我们可以创造更可持续的食品和卫生系统，造福我们的社会。