Mechanical Biomarkers of Chronic Low Back Pain
慢性腰痛的机械生物标志物
基本信息
- 批准号:10440260
- 负责人:
- 金额:$ 61.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-22 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAcuteAddressAdultAffectBack PainBehavior TherapyBehavioralBiochemicalBiochemical MarkersBiological MarkersCharacteristicsChronicChronic low back painClinicalClinical TrialsCluster AnalysisCognitiveComplexDataDevelopmentEtiologyGoalsHeterogeneityImageImaging DeviceIndividualInflammatoryInterventionIntervertebral disc structureKnowledgeLeadLow Back PainMachine LearningMagnetic Resonance ImagingMeasurementMeasuresMechanical Low Back PainMechanicsMethodsModelingNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNatureNeuropeptidesOperative Surgical ProceduresPainPain ResearchParticipantPatient SelectionPatient Self-ReportPatient-Focused OutcomesPatientsPharmacologic SubstancePhenotypePopulationProcessPublic HealthRehabilitation therapyResearchResearch PriorityRisk FactorsRoleSensorySiteSourceSpeedSubgroupSymptomsTechniquesTestingVertebral columnWorkbasebiopsychosocialbiopsychosocial factorcentral painchronic musculoskeletal painclinical careclinical developmentclinical imagingclinical phenotypecostdemographicsexperienceimaging biomarkerimprovedimproved outcomein vivoin vivo imaginginflammatory paininnovationintervertebral disk degenerationlongitudinal analysisnoveloptimal treatmentspatient subsetsradiological imagingrandom forestthree-dimensional modeling
项目摘要
Abstract
The intervertebral disc (IVD) has an essential role in transferring load during normal spine function and when
this normal function fails, symptoms, degeneration and altered spine mechanics may occur. The overall
scientific premise of this work is that there is a gap in knowledge of the relationship between contributions from
mechanical, inflammatory and biopsychosocial factors that lead to chronic low back pain (LBP). An important
gap is a poor understanding of the relationship between IVD degeneration and LBP. This lack of understanding
leads to discordance between imaging and self-reported pain and, ultimately, treatments being delivered by an
exclusionary process. To address this gap, we will use innovative in vivo imaging tools to quantify the
mechanical function of the IVD. We will also measure quantitative sensory factors, biochemical markers, and
biopsychosocial factors that, when combined with mechanical function, may better identify subgroups or
phenotypes of LBP. The overall goal of this project is to identify if mechanical function of the IVD is a potential
risk factor and whether mechanical function can assist with defining phenotypes of LBP. The findings from this
study would lead to longitudinal analyses to determine whether these phenotypes predict the transition from
acute to chronic LBP. The rationale for this proposed research is that: 1) altered mechanical function of the IVD
contributes to LBP. 2) LBP is a heterogeneous condition that can result from a combination of mechanical,
inflammatory, and central pain based sources. The central hypothesis is that in vivo measured IVD mechanical
function will be an important potential risk factor for both acute and chronic non-specific LBP and that this
measure will improve the phenotyping of LBP. In Aim I, we will quantify the association between in-vivo
measured IVD mechanical function among acute and chronic non-specific LBP participants and asymptomatic
controls. In Aim II, we will derive well-defined phenotypes of LBP using combinations of potential risk factors.
Identifying phenotypes of LBP will allow for specific rehabilitation, surgical, pharmaceutical or behavioral
treatments to be targeted, resulting in improved patient outcomes.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Louis E. DeFrate其他文献
113 - EVALUATION OF SEX DIFFERENCES IN INTERVERTEBRAL DISC STRAIN AND MODIFIED PFIRRMANN GRADE
- DOI:
10.1016/j.joca.2024.02.124 - 发表时间:
2024-04-01 - 期刊:
- 影响因子:
- 作者:
Nicole E. Zimmer;James A. Coppock;Andrzej S. Kosinski;Charles E. Spritzer;Adam P. Goode;Louis E. DeFrate - 通讯作者:
Louis E. DeFrate
Three-dimensional analysis of cervical spine motion: reliability of a computer assisted magnetic tracking device compared to inclinometer
- DOI:
10.1007/s00586-008-0853-0 - 发表时间:
2008-12-19 - 期刊:
- 影响因子:2.700
- 作者:
Ioannis D. Gelalis;Louis E. DeFrate;Kosmas S. Stafilas;Emilios E. Pakos;James D. Kang;Lars G. Gilbertson - 通讯作者:
Lars G. Gilbertson
Tibiofemoral cartilage strain and recovery following a 3-mile run measured using deep learning segmentation of bone and cartilage
- DOI:
10.1016/j.ocarto.2024.100556 - 发表时间:
2025-03-01 - 期刊:
- 影响因子:
- 作者:
Patrick X. Bradley;Sophia Y. Kim-Wang;Brooke S. Blaisdell;Alexie D. Riofrio;Amber T. Collins;Lauren N. Heckelman;Eziamaka C. Obunadike;Margaret R. Widmyer;Chinmay S. Paranjape;Bryan S. Crook;Nimit K. Lad;Edward G. Sutter;Brian P. Mann;Charles E. Spritzer;Louis E. DeFrate - 通讯作者:
Louis E. DeFrate
Reconsidering Reciprocal Fundation of Anterior Cruciate Ligament Bundles During In Vivo Gait
- DOI:
10.1016/j.arthro.2020.12.149 - 发表时间:
2021-01-01 - 期刊:
- 影响因子:
- 作者:
Zoë A. Englander;Jocelyn R. Wittstein;William E. Garrett;Louis E. DeFrate - 通讯作者:
Louis E. DeFrate
Resting Supine for 45 Minutes Yields Consistent Baseline Lumbar Intervertebral Disc Height in Asymptomatic Participants
- DOI:
10.1007/s10439-025-03749-4 - 发表时间:
2025-05-13 - 期刊:
- 影响因子:5.400
- 作者:
Nicole E. Zimmer;James A. Coppock;Andrzej S. Kosinski;Charles E. Spritzer;Adam P. Goode;Louis E. DeFrate - 通讯作者:
Louis E. DeFrate
Louis E. DeFrate的其他文献
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{{ truncateString('Louis E. DeFrate', 18)}}的其他基金
2022 Musculoskeletal Biology & Bioengineering Gordon Research Conference & Gordon Research Seminar
2022 肌肉骨骼生物学
- 批准号:
10378272 - 财政年份:2022
- 资助金额:
$ 61.68万 - 项目类别:
Biomechanical and Biological Predictors of Cartilage Health Following Meniscus Injury
半月板损伤后软骨健康的生物力学和生物学预测因子
- 批准号:
10383708 - 财政年份:2021
- 资助金额:
$ 61.68万 - 项目类别:
Biomechanical and Biological Predictors of Cartilage Health Following Meniscus Injury
半月板损伤后软骨健康的生物力学和生物学预测因子
- 批准号:
10230722 - 财政年份:2021
- 资助金额:
$ 61.68万 - 项目类别:
Biomechanical and Biological Predictors of Cartilage Health Following Meniscus Injury
半月板损伤后软骨健康的生物力学和生物学预测因子
- 批准号:
10588182 - 财政年份:2021
- 资助金额:
$ 61.68万 - 项目类别:
Biomechanical and Biological Predictors of Cartilage Health Following Meniscus Injury
半月板损伤后软骨健康的生物力学和生物学预测因子
- 批准号:
10751974 - 财政年份:2021
- 资助金额:
$ 61.68万 - 项目类别:
Weight loss, in vivo cartilage mechanics, and joint health
减肥、体内软骨力学和关节健康
- 批准号:
10091305 - 财政年份:2019
- 资助金额:
$ 61.68万 - 项目类别:
Weight loss, in vivo cartilage mechanics, and joint health
减肥、体内软骨力学和关节健康
- 批准号:
10536658 - 财政年份:2019
- 资助金额:
$ 61.68万 - 项目类别:
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