Engineering Biology for the Treatment of Solid Tumours : Enhancing T Cell Function and Longevity in the Tumour Microenvironment for Improved Cancer Immunotherapy

治疗实体瘤的工程生物学：增强肿瘤微环境中的 T 细胞功能和寿命，以改善癌症免疫治疗

• 批准号: 10074648
• 金额: $ 6.3万
• 依托单位: OXYGENICA LTD
• 依托单位国家: 英国
• 项目类别: Grant for R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10074648
• 关键词: Engineering; Biology; Treatment; Solid; Tumours

This project aims to develop an innovative cancer treatment that focuses on **improving the function and longevity of immune cells**, specifically T cells, within the challenging environment of **solid tumours**. T cells play a crucial role in our body's ability to combat cancer; however, they often become exhausted and lose their effectiveness when facing the harsh conditions present within solid tumours.Our proposed solution involves the development of a **cutting-edge genetic tool** that can be introduced into **T cells**, allowing them to better withstand the difficult environment and maintain their ability to fight cancer. This tool will be designed to activate only under specific conditions, ensuring that it does not negatively impact the natural function of the T cells.By developing this groundbreaking approach, we aim to enhance the **effectiveness of existing cancer immunotherapies**, providing a superior treatment option for patients with solid tumours. This innovation holds significant promise for improving patient outcomes and transforming cancer treatment in the years to come.The **market opportunity** for this novel cancer treatment is vast, as it addresses an unmet need in the field of **immuno-oncology**. The successful development and implementation of this solution will not only benefit patients but also support the growth of new businesses within the UK and European ecosystems. Additionally, the **socio-economic impact** of this innovative cancer therapy will be substantial, as it has the potential to reduce healthcare costs and improve the quality of life for countless individuals affected by solid tumours. In summary, this project represents a significant advancement in the fight against cancer and holds the potential to transform the treatment landscape for the better.

该项目旨在开发一种创新的癌症治疗方法，专注于**改善免疫细胞的功能和寿命**，特别是T细胞，在具有挑战性的**实体肿瘤**环境中。T细胞在我们身体对抗癌症的能力中起着至关重要的作用；然而，当面对实体肿瘤中存在的严酷条件时，它们往往会精疲力竭并失去效力。我们提出的解决方案涉及开发一种**尖端遗传工具**，它可以被引入**T细胞**，使它们能够更好地抵御困难的环境，并保持其抗癌能力。这一工具将仅在特定条件下激活，确保它不会对T细胞的自然功能产生负面影响。通过开发这一开创性的方法，我们的目标是增强现有癌症免疫疗法的**有效性**，为实体瘤患者提供更好的治疗选择。这项创新在未来几年为改善患者预后和改变癌症治疗带来了巨大的希望。这种新型癌症治疗的**市场机会**是巨大的，因为它解决了**免疫肿瘤学**领域尚未得到满足的需求。这一解决方案的成功开发和实施不仅将使患者受益，还将支持英国和欧洲生态系统内新业务的增长。此外，这种创新的癌症疗法的**社会经济影响**将是巨大的，因为它有可能降低医疗保健成本，并提高无数受实体肿瘤影响的个人的生活质量。总而言之，该项目代表着抗击癌症的重大进步，并具有使治疗格局变得更好的潜力。