Integrating biology and medicine to develop 3D-structure guided drug design for treatment of cardiovascular disease

整合生物学和医学开发用于治疗心血管疾病的3D结构引导药物设计

• 批准号: nhmrc : 2004282
• 金额: $ 97.88万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/integrating-biology-medicine-cardiovascular-disease/1780308
• 关键词: Integrating; biology; medicine; develop; 3D

Calcium channel inhibitors are commonly prescribed for the treatment of heart disorders such as angina, hypertension, arrhythmias and hypertrophic heart disease. This class of drugs is one of the leading causes of drug-related fatalities. The impediment to designing better drugs is a lack of understanding of the 3 dimensional (3D) structure of the calcium channel. We will enable for the first time a 3D structure blueprint for the design of safe and highly selective calcium channel therapeutics.

钙通道抑制剂通常用于治疗心脏疾病，如心绞痛、高血压、心律失常和肥厚性心脏病。这类药物是与药物有关的死亡的主要原因之一。设计更好的药物的障碍是缺乏对钙通道的三维（3D）结构的理解。我们将首次为设计安全和高选择性的钙通道疗法提供3D结构蓝图。