Administrative Core

摘要 有一个迫切的未满足的需要，以确定最早的细胞和分子事件，与肺 致癌作用在这项提案中，我们将为两种最常见的肺癌亚型开发一个癌前图谱， 癌症：鳞状细胞癌（LUSC）和腺癌（LUAD）。我们的团队成员提供 在临床试验、癌症基因组学、转录组学和蛋白质组学、免疫生物学、 生物统计学、计算生物学和数据门户开发。为了促进肺预- 癌症地图集（PCA），行政核心，由核心主任和中心管理员组成，将 为研究中心及其单位提供运营和战略管理及支持。具体地说， 核心部队将为后分析部队提供全面的中心管理、评估和项目支持 各PCA单位内的牵头人和共同调查员，包括协调标准操作 程序、数据共享计划、分包合同、电话会议和正式会议，以及对该股的监测 中求进工作总此外，核心小组还将促进常设协商和行政事务股与该股领导之间的协同增效和一体化， 包括以电话会议和正式会议的形式进行定期沟通， 各单位之间的生物标本和数据，并将提供中心进展的最新信息，以使研究者 通知即将到来的数据。重要的是，核心将建立和培养一种双向沟通， 基础设施和与人类肿瘤图谱（HTA）网络的交换，以确保符合公认的 网络实践和原则，并交换计划见解和数据，以促进PCA的整合 HTA研究中心核心小组的一项重要职责是执行评价计划 这将简化和提高三个肺部PCA单位的效率，以促进进展 为了具体的目标。该评估将包括过程映射，以向所有人传达预期目标 PCA调查员，衡量单位及其整合成功的定义明确的指标，以及网络- 为有效收集和共享单位评价数据提供了一个基于工具的平台。这一评估将使及时、持续的 改善，并培育一个丰富和刺激的科学环境和综合基础设施，以产生一个 强大和信息丰富的地图集。总之，行政核心将提供必要的治理，以确保 在肺PCA内进行稳健的数据收集和分析，并促进图谱结果向 HTA网络和扩展的研究社区。

ABSTRACT There is an urgent unmet need to identify the earliest cellular and molecular events that associate with lung carcinogenesis. In this proposal, we will develop a pre-cancer atlas for the two most common subtypes of lung cancer: squamous cell (LUSC) and adenocarcinoma (LUAD). The members of our team provide complementary expertise in clinical trials, cancer genomics, transcriptomics and proteomics, immunobiology, biostatistics, computational biology, and data portal development. To facilitate the construction of the Lung Pre- cancer Atlas (PCA), the Administrative Core, consisting of the Core Director and Center Administrator, will provide operational and strategic management and support to the Research Center and its Units. Specifically, the Core will provide comprehensive Center management, evaluation, and project support to the PCA Unit leads and co-investigators within the individual PCA Units including coordination of standard operating procedures, data sharing plans, subcontracts, teleconferences and formal meetings, and monitoring of Unit progress. In addition, the Core will also foster synergy and integration between the PCA Units and Unit leads, including regular communication in the form of teleconferences and formal meetings, coordinate sharing of biospecimens and data between Units and will provide updates on Center progress to keep investigators informed of impending data. Importantly, the Core will establish and cultivate a bidirectional communication infrastructure and exchange with the Human Tumor Atlas (HTA) network to ensure conformity with accepted network practices and principles and exchange program insights and data to facilitate integration of the PCA and HTA Research Centers. An important responsibility of the Core will be implementing an evaluation plan that will streamline and improve efficiencies across the three Lung PCA Units in order to facilitate progress towards the specific aims. This evaluation will include process mapping to communicate intended goals to all PCA investigators, well-defined metrics that measure success of the Units and their integration, and web- based tools to efficiently collect and share Unit evaluation data. This evaluation will enable timely continuous improvement, and foster a rich and stimulating scientific environment and integrated infrastructure to produce a robust and informative Atlas. In all, the Administrative Core will provide necessary governance for ensuring robust data collection and analysis within the Lung PCA, and facilitate dissemination of atlas findings to the HTA network and extended research community.