Administrative Core

摘要 迫切需要确定与肺相关的最早的细胞和分子事件 致癌。在这项提案中，我们将为两种最常见的肺亚型开发一份癌前图谱。 癌症：鳞状细胞癌(LUSC)和腺癌(LUAD)。我们团队的成员提供 在临床试验、癌症基因组学、转录组和蛋白质组学、免疫生物学、 生物统计学、计算生物学和数据门户开发。为促进肺前区的建设 癌症地图集(PCA)是行政核心，由核心主任和中心管理员组成，将 为研究中心及其单位提供业务和战略管理及支持。具体来说， 该核心将向PCA股提供全面的中心管理、评价和项目支助 各常设警察部队内的领导和协查人员，包括协调标准运作 程序、数据共享计划、分包合同、电话会议和正式会议以及联检组的监测 进步。此外，核心还将促进警察部队股和股领导之间的协同作用和一体化， 包括以电话会议和正式会议的形式定期沟通，协调分享 各单位之间的生物谱和数据，并将提供中心进展的最新情况，以保持调查人员 被告知即将到来的数据。重要的是，核心将建立和培养双向沟通 基础设施和与人类肿瘤图谱(HTA)网络的交流，以确保符合公认的 网络实践和原则，并交流方案见解和数据，以促进PCA的整合 和HTA研究中心。核心的一项重要责任将是执行评价计划 这将精简和提高三个肺性心肺复原股的效率，以促进进展 朝着特定的目标前进。这项评估将包括流程映射，以向所有人传达预期目标 PCA调查人员，衡量各单位及其整合成功的明确指标，以及网络- 以工具为基础，有效地收集和共享单位评价数据。这项评估将使及时连续 改善，并培育丰富和激励的科学环境和综合基础设施，以产生 强大和信息量大的地图集。总之，行政核心将提供必要的治理，以确保 在肺脏保护局内进行强有力的数据收集和分析，并促进将地图集调查结果传播给 HTA网络和扩展的研究社区。

ABSTRACT There is an urgent unmet need to identify the earliest cellular and molecular events that associate with lung carcinogenesis. In this proposal, we will develop a pre-cancer atlas for the two most common subtypes of lung cancer: squamous cell (LUSC) and adenocarcinoma (LUAD). The members of our team provide complementary expertise in clinical trials, cancer genomics, transcriptomics and proteomics, immunobiology, biostatistics, computational biology, and data portal development. To facilitate the construction of the Lung Pre- cancer Atlas (PCA), the Administrative Core, consisting of the Core Director and Center Administrator, will provide operational and strategic management and support to the Research Center and its Units. Specifically, the Core will provide comprehensive Center management, evaluation, and project support to the PCA Unit leads and co-investigators within the individual PCA Units including coordination of standard operating procedures, data sharing plans, subcontracts, teleconferences and formal meetings, and monitoring of Unit progress. In addition, the Core will also foster synergy and integration between the PCA Units and Unit leads, including regular communication in the form of teleconferences and formal meetings, coordinate sharing of biospecimens and data between Units and will provide updates on Center progress to keep investigators informed of impending data. Importantly, the Core will establish and cultivate a bidirectional communication infrastructure and exchange with the Human Tumor Atlas (HTA) network to ensure conformity with accepted network practices and principles and exchange program insights and data to facilitate integration of the PCA and HTA Research Centers. An important responsibility of the Core will be implementing an evaluation plan that will streamline and improve efficiencies across the three Lung PCA Units in order to facilitate progress towards the specific aims. This evaluation will include process mapping to communicate intended goals to all PCA investigators, well-defined metrics that measure success of the Units and their integration, and web- based tools to efficiently collect and share Unit evaluation data. This evaluation will enable timely continuous improvement, and foster a rich and stimulating scientific environment and integrated infrastructure to produce a robust and informative Atlas. In all, the Administrative Core will provide necessary governance for ensuring robust data collection and analysis within the Lung PCA, and facilitate dissemination of atlas findings to the HTA network and extended research community.