Administrative Core

行政核心

• 批准号: 10441646
• 负责人: Avrum E Spira
• 金额: $ 10万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10441646
• 关键词: Adenocarcinoma; Administrative Coordination; Administrator; Atlases; Biological Assay; Biometry; Budgets; Clinical; Clinical Research; Clinical Trials; Communication; Communities; Computational Biology; Data; Data Analyses; Data Collection; Development; Ensure; Environment; Evaluation; Event; Fostering; Funding; Genomics; Goals; Guidelines; Human; Immunobiology; Individual; Infrastructure; Institution; Leadership; Lung; Measures; Mission; Molecular; Molecular Biology; Molecular Computations; Monitor; Outcome; Procedures; Process; Proteomics; Protocols documentation; Research; Research Personnel; Resources; Services; Site; Site Visit; Specimen; Squamous Cell Lung Carcinoma; Standardization; Teleconferences; Time; Tissues; Update; cancer genomics; cohesion; data dissemination; data exchange; data integration; data portal; data sharing; flexibility; improved; insight; lung carcinogenesis; meetings; member; operation; programs; success; synergism; transcriptomics; tumor; web-based tool

ABSTRACT There is an urgent unmet need to identify the earliest cellular and molecular events that associate with lung carcinogenesis. In this proposal, we will develop a pre-cancer atlas for the two most common subtypes of lung cancer: squamous cell (LUSC) and adenocarcinoma (LUAD). The members of our team provide complementary expertise in clinical trials, cancer genomics, transcriptomics and proteomics, immunobiology, biostatistics, computational biology, and data portal development. To facilitate the construction of the Lung Pre- cancer Atlas (PCA), the Administrative Core, consisting of the Core Director and Center Administrator, will provide operational and strategic management and support to the Research Center and its Units. Specifically, the Core will provide comprehensive Center management, evaluation, and project support to the PCA Unit leads and co-investigators within the individual PCA Units including coordination of standard operating procedures, data sharing plans, subcontracts, teleconferences and formal meetings, and monitoring of Unit progress. In addition, the Core will also foster synergy and integration between the PCA Units and Unit leads, including regular communication in the form of teleconferences and formal meetings, coordinate sharing of biospecimens and data between Units and will provide updates on Center progress to keep investigators informed of impending data. Importantly, the Core will establish and cultivate a bidirectional communication infrastructure and exchange with the Human Tumor Atlas (HTA) network to ensure conformity with accepted network practices and principles and exchange program insights and data to facilitate integration of the PCA and HTA Research Centers. An important responsibility of the Core will be implementing an evaluation plan that will streamline and improve efficiencies across the three Lung PCA Units in order to facilitate progress towards the specific aims. This evaluation will include process mapping to communicate intended goals to all PCA investigators, well-defined metrics that measure success of the Units and their integration, and web- based tools to efficiently collect and share Unit evaluation data. This evaluation will enable timely continuous improvement, and foster a rich and stimulating scientific environment and integrated infrastructure to produce a robust and informative Atlas. In all, the Administrative Core will provide necessary governance for ensuring robust data collection and analysis within the Lung PCA, and facilitate dissemination of atlas findings to the HTA network and extended research community.

抽象的 紧急未满足地确定与肺相关的最早的细胞和分子事件 致癌作用。在此提案中，我们将为两个最常见的肺类型开发一个前癌地图集 癌症：鳞状细胞（LUSC）和腺癌（LUAD）。我们团队的成员提供 临床试验，癌症基因组学，转录组学和蛋白质组学，免疫生物学的补充专业知识， 生物统计学，计算生物学和数据门户发展。促进肺前的建造 由核心董事和中心管理员组成的行政核心癌症地图集（PCA）将 为研究中心及其单位提供运营和战略管理和支持。具体来说， 核心将为PCA部门提供全面的中心管理，评估和项目支持 单个PCA单元内的引线和共同评估器，包括标准操作的协调 程序，数据共享计划，分包合同，电信和正式会议以及对单位的监视 进步。此外，核心还将促进PCA单元和单位线索之间的协同作用和集成， 包括定期沟通以电视会议和正式会议的形式，协调共享 生物测量和单元之间的数据，并将提供有关中心进度的最新信息，以保持调查人员 得知即将到来的数据。重要的是，核心将建立和培养双向交流 基础设施和与人类肿瘤（HTA）网络交流，以确保与接受 网络实践，原理和交换计划的见解和数据，以促进PCA集成 和HTA研究中心。核心的重要责任是实施评估计划 这将简化和提高三个肺PCA单元的效率，以促进进步 朝着具体目标。该评估将包括过程映射以将预期目标传达给所有人 PCA调查人员，定义明确的指标，衡量单位的成功及其集成以及网络 基于有效收集和共享单位评估数据的工具。该评估将使及时连续 改进，并促进丰富而刺激的科学环境和综合基础设施，以产生 强大而有益的地图集。总之，行政核心将为确保 肺PCA内的强大数据收集和分析，并促进将Atlas发现传播到 HTA网络和扩展研究社区。