Administrative Core

行政核心

• 批准号: 10441646
• 负责人: Avrum E Spira
• 金额: $ 10万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10441646
• 关键词: Adenocarcinoma; Administrative Coordination; Administrator; Atlases; Biological Assay; Biometry; Budgets; Clinical; Clinical Research; Clinical Trials; Communication; Communities; Computational Biology; Data; Data Analyses; Data Collection; Development; Ensure; Environment; Evaluation; Event; Fostering; Funding; Genomics; Goals; Guidelines; Human; Immunobiology; Individual; Infrastructure; Institution; Leadership; Lung; Measures; Mission; Molecular; Molecular Biology; Molecular Computations; Monitor; Outcome; Procedures; Process; Proteomics; Protocols documentation; Research; Research Personnel; Resources; Services; Site; Site Visit; Specimen; Squamous Cell Lung Carcinoma; Standardization; Teleconferences; Time; Tissues; Update; cancer genomics; cohesion; data dissemination; data exchange; data integration; data portal; data sharing; flexibility; improved; insight; lung carcinogenesis; meetings; member; operation; programs; success; synergism; transcriptomics; tumor; web-based tool

ABSTRACT There is an urgent unmet need to identify the earliest cellular and molecular events that associate with lung carcinogenesis. In this proposal, we will develop a pre-cancer atlas for the two most common subtypes of lung cancer: squamous cell (LUSC) and adenocarcinoma (LUAD). The members of our team provide complementary expertise in clinical trials, cancer genomics, transcriptomics and proteomics, immunobiology, biostatistics, computational biology, and data portal development. To facilitate the construction of the Lung Pre- cancer Atlas (PCA), the Administrative Core, consisting of the Core Director and Center Administrator, will provide operational and strategic management and support to the Research Center and its Units. Specifically, the Core will provide comprehensive Center management, evaluation, and project support to the PCA Unit leads and co-investigators within the individual PCA Units including coordination of standard operating procedures, data sharing plans, subcontracts, teleconferences and formal meetings, and monitoring of Unit progress. In addition, the Core will also foster synergy and integration between the PCA Units and Unit leads, including regular communication in the form of teleconferences and formal meetings, coordinate sharing of biospecimens and data between Units and will provide updates on Center progress to keep investigators informed of impending data. Importantly, the Core will establish and cultivate a bidirectional communication infrastructure and exchange with the Human Tumor Atlas (HTA) network to ensure conformity with accepted network practices and principles and exchange program insights and data to facilitate integration of the PCA and HTA Research Centers. An important responsibility of the Core will be implementing an evaluation plan that will streamline and improve efficiencies across the three Lung PCA Units in order to facilitate progress towards the specific aims. This evaluation will include process mapping to communicate intended goals to all PCA investigators, well-defined metrics that measure success of the Units and their integration, and web- based tools to efficiently collect and share Unit evaluation data. This evaluation will enable timely continuous improvement, and foster a rich and stimulating scientific environment and integrated infrastructure to produce a robust and informative Atlas. In all, the Administrative Core will provide necessary governance for ensuring robust data collection and analysis within the Lung PCA, and facilitate dissemination of atlas findings to the HTA network and extended research community.

抽象的 目前迫切需要确定与肺相关的最早的细胞和分子事件 致癌作用。在本提案中，我们将为两种最常见的肺癌亚型开发一个癌前图谱 癌症：鳞状细胞癌（LUSC）和腺癌（LUAD）。我们团队的成员提供 临床试验、癌症基因组学、转录组学和蛋白质组学、免疫生物学、 生物统计学、计算生物学和数据门户开发。为促进肺预科建设 癌症阿特拉斯 (PCA) 是一个行政核心，由核心主任和中心管理员组成，将 为研究中心及其单位提供运营和战略管理及支持。具体来说， 核心将为 PCA 部门提供全面的中心管理、评估和项目支持 各个 PCA 单位内的领导者和联合研究者，包括标准操作的协调 程序、数据共享计划、分包合同、电话会议和正式会议以及对单位的监测 进步。此外，核心还将促进 PCA 部门和部门领导之间的协同和整合， 包括以电话会议和正式会议的形式进行定期沟通，协调共享 单位之间的生物样本和数据，并将提供中心进展的最新信息，以保持研究人员的 获悉即将发布的数据。重要的是，核心将建立和培养双向沟通 基础设施以及与人类肿瘤图谱 (HTA) 网络的交换，以确保符合公认的标准 网络实践和原则并交换计划见解和数据以促进 PCA 的集成 和 HTA 研究中心。核心的一项重要职责是实施评估计划 这将简化并提高三个 Lung PCA 部门的效率，以促进进展 朝着具体目标迈进。该评估将包括流程图，以向所有人传达预期目标 PCA 调查员、衡量各单元及其集成成功与否的明确定义的指标以及网络- 基于工具来有效收集和共享单位评估数据。该评估将能够及时、持续地 改善，并培育丰富和激励性的科学环境和综合基础设施，以产生 强大且信息丰富的 Atlas。总之，行政核心将提供必要的治理，以确保 Lung PCA 内强大的数据收集和分析，并促进将图集结果传播给 HTA 网络和扩展研究社区。