Pilot and Exploratory Studies Core (PESC)

试点和探索性研究核心（PESC）

• 批准号: 10441443
• 负责人: Kenneth S. Boockvar
• 金额: $ 33.32万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10441443
• 关键词: Address; Aging; Alzheimer' s disease related dementia; Applications Grants; Award; Capsicum; Caregivers; Caring; Chronic Disease; Chronic Obstructive Pulmonary Disease; Conflict (Psychology); Data; Dementia; Development; Discipline; Distress; Elderly; Experimental Designs; Faculty; Family; Fostering; Foundations; Funding; Funding Agency; Future; Generations; Geriatrics; Goals; Grant; Head and Neck Cancer; Health; Home; Individual; Institution; Interdisciplinary Study; Intervention; K-Series Research Career Programs; Leadership; Malignant neoplasm of liver; Medicare; Methodology; Methods; Minority; Monitor; Neurology; Nursery Schools; Pain; Palliative Care; Patients; Perception; Performance Status; Persons; Pilot Projects; Predisposing Factor; Provider; Psychiatry; Publications; Qualitative Methods; Quality of life; Radiation; Research; Research Institute; Research Personnel; Research Project Grants; Research Support; Signal Transduction; Source; Surveys; Symptoms; System; Testing; Translational Research; Triage; Universities; Woman; Work; anxiety treatment; base; beneficiary; career; career development; clinical center; dementia care; design; disability; education research; evidence base; experience; feasibility testing; follower of religion Jewish; health care disparity; implementation science; improved; medical specialties; older patient; outreach; palliative; pilot test; population based; population health; programs; response; senior faculty; trend

SUMMARY/ABSTRACT PILOT AND EXPLORATORY STUDIES CORE (PESC) Evidence exists that patients with Alzheimer’s Disease and Related Dementias (ADRD) and other serious illness experience profoundly distressing symptoms that overwhelm them and their families. Pilot funding is needed in geriatric palliative care (GPC) to support investigators as they test the feasibility of new methodological or interventional approaches, to examine data for initial signals that support continuing to definitive studies, and to help junior investigators make the transition to independent funding. In this OAIC renewal application we propose a Pilot and Exploratory Studies Core (PESC) that builds upon our Mount Sinai OAIC 2015-19 experience that will accomplish the following aims: 1) support pilot and exploratory studies that a) examine the relationship between distressing symptoms and independence, function, and disability; b) develop interventions directed at distressing symptoms, quality of life, function, and independence for older adults with ADRD and other serious and chronic illness, and c) advance methods for the study of care of older adults with ADRD and other serious illness; 2) support the development of preliminary data in aging and palliative care that will lead to the development of larger research projects and career development awards focused on improving care and promoting independence for older adults with ADRD and other serious illness; 3) support junior faculty who are embarking on research careers in palliative care and aging, as well as mid- level and senior faculty who are embarking on research projects requiring pilot data or who are refocusing their work to fit within the OAIC theme; and 4) foster collaborative research among investigators from varied disciplines, specialties, and institutions. To accomplish these aims the PESC will: 1) solicit pilot studies from investigators within and outside the OAIC, with particular outreach to junior faculty; 2) review and select projects that fit the OAIC themes and support career development; 3) monitor study progress; and 4) assist in planning independent grant applications. We will give special consideration to projects that address two new cross-cutting OAIC themes: 1) the intersection between dementia and serious illness and 2) implementation science, and we will prioritize women and minority applicants. We will fund standard pilot applications (size: $50-75,000; duration: 1-2 years), and small pilot applications (size: $10-$25K; duration: 1 year), to permit rapid generation of pilot data and rapid response to RFAs. Mount Sinai’s faculty and programs in geriatrics, palliative care, population health, neurology, dementia, and psychiatry, and its affiliations with the Bronx VA Geriatrics Research Education and Clinical Center (GRECC), The Hebrew Home Research Division, The New Jewish Home Research Institute on Aging, and University of Rochester, will be a large source of potential PESC investigators.

总结/摘要 试点和探索性研究核心（PESC） 有证据表明，患有阿尔茨海默病和相关痴呆症（ADRD）和其他严重疾病的患者经历了令人深感痛苦的症状，这些症状使他们及其家人不堪重负。老年姑息治疗（GPC）需要试点资金，以支持研究人员测试新方法或干预方法的可行性，检查支持继续进行确定性研究的初始信号的数据，并帮助初级研究人员过渡到独立资助。在这个OAIC更新申请中，我们提出了一个试点和探索性研究核心（PESC），该核心建立在我们的西奈山OAIC 2015-19经验的基础上，将实现以下目标：1）支持试点和探索性研究， a）检查痛苦症状与独立性、功能和残疾之间的关系; B）针对患有ADRD和其他严重和慢性疾病的老年人的痛苦症状、生活质量、功能和独立性制定干预措施，以及c）先进的方法用于研究患有ADRD和其他严重疾病的老年人的护理; 2）支持老龄化和姑息治疗的初步数据的发展，这将导致更大的研究项目和职业发展奖的发展，重点是改善护理和促进ADRD和其他严重疾病的老年人的独立性; 3)支持初级教师谁是在姑息治疗和老龄化的研究生涯开始，以及中级和高级教师谁是在需要试点数据的研究项目开始，或谁是重新调整他们的工作，以适应在OAIC主题; 2和4）促进合作研究之间的研究人员从不同的学科，专业和机构。为了实现这些目标，PESC将：1）征求OAIC内外调查人员的试点研究，特别是初级教师; 2）审查和选择适合OAIC主题和支持职业发展的项目; 3）监测研究进展;和4）协助规划独立的赠款申请。我们将特别考虑解决两个新的跨领域OAIC主题的项目：1）痴呆症和严重疾病之间的交叉点和2）实施科学，我们将优先考虑女性和少数民族申请人。我们将资助标准试点应用程序（规模： 50 - 75，000美元;持续时间：1-2年）和小型试点应用程序（规模：10 - 25，000美元;持续时间：1年），以便快速生成试点数据和对RFAs快速作出反应。西奈山的教师和计划在老年病，姑息治疗，人口健康，神经学，痴呆症和精神病学，其附属机构与布朗克斯VA老年病研究教育和临床中心（GRECC），希伯来家庭研究部，新的犹太家庭老龄化研究所，和罗切斯特大学，将是一个潜在的PESC研究人员的大来源。