Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease

项目总结 我们消化健康中心(DHC)的总体目标：儿科的床到床研究 消化系统疾病是为了促进对消化系统疾病的基本过程和致病机理的深入研究 儿童消化系统疾病的机制，并产生恢复消化健康的创新治疗方法。这个 核心目标是：1)加强研究基础并促进合作，2)通过以下方式促进发现 使调查人员能够接触到高度创新的核心，以及3)培养初级调查人员和未来 该领域的领先者。DHC的上一个获奖期非常成功，核心服务发展到 满足创新调查人员的科学需求。我们由68名研究人员组成的研究基地吸引了36.5美元 每年有数百万美元的校外消化疾病相关基金；他们在过去4年里发表了630篇文章。 几名试点和可行性(P/F)获奖者过渡到由R01资助的研究人员和整个研究 社区受益于展示消化系统疾病最新进展的科学丰富计划 研究。这一成功的轨迹将在未来几年通过促进研究和促进 部门间和部门间的协作，以保持消化疾病研究的坚实临界量 专注于翻译研究。具体地说，我们的长期目标是通过 我们的三个关键领域的高度创新工作将带来更好的诊断、治疗和结果 重点领域：1)肝病模型的机制，2)消化系统疾病与免疫，3)干细胞 消化系统疾病的细胞和器官模型。每个重点领域都带来了潜在影响的机会 关于儿童的消化健康，有助于推进国家研究议程，并创造了一个独特的 将研究与病人护理相结合的环境。重点领域由三个相辅相成的 独一无二的创新生物医学研究核心(基因分析核心、综合形态核心和 干细胞/器官核心和基因组编辑核心)和行政管理的临床组成部分 核心以促进以患者为基础的研究。这些核心和临床组件共同构成了一个强大的 基础设施，促进个性化和预测性医疗方法的发展 胃肠道疾病的遗传学和分子基础，以及考虑到胃肠道疾病基本机制的治疗方法 疾病。我们的工作模式促进实验室发现，创造翻译研究机会 这导致了对患者样本的验证，并导致了临床试验。为加强消化系统疾病的研究， DHC将促进其研究人员和来自其他学科的研究人员之间的合作。它还将为 非常有希望的初级调查人员的P/F项目，并将赞助一个动态丰富计划 科学研讨会、讲习班和座谈会。有了这些策略和特别的支持 作为一家机构，DHC处于有利地位，可以催化儿科消化系统疾病的转化研究。

PROJECT SUMMARY The overall goal of our Digestive Health Center (DHC): Bench-to-Bedside Research in Pediatric Digestive Disease is to promote research that will yield insights into the fundamental processes and pathogenic mechanisms of digestive disease in children and generate innovative treatment to restore digestive health. The Cores aims are: 1) to strengthen the Research Base and foster collaborations, 2) to catalyze discoveries by giving investigators access to highly innovative Cores, and 3) to develop junior investigators and the future leaders in the field. The last award period of the DHC was very successful, with Core services that evolved to meet the scientific needs of innovative investigators. Our Research Base of 68 investigators attracts $36.5 million of extramural digestive disease-related funds annually; they published 630 articles in the last 4 years. Several Pilot and Feasibility (P/F) Awardees transitioned to R01-funded investigators and the entire research community benefitted from a scientific Enrichment Program presenting the latest advances in digestive disease research. This trajectory of success will be pursued in future years by fostering research and promoting interdivisional and interdepartmental collaboration to maintain a solid critical mass in digestive disease research with a focus on translational research. Specifically, our long-term goals are to improve child health through better diagnosis, treatments and outcomes that will emerge from highly innovative work in our three key focus areas: 1) Mechanisms of Liver Disease modeling, 2) Digestive Disease and Immunity, and 3) Stem Cell and Organoid Modeling of Digestive Diseases. Each focus area brings opportunities for potential impact on the digestive health of children, helps advance the national research agenda, and creates a unique environment to integrate research into patient care. The focus areas are linked by three complementary and uniquely innovative Biomedical Research Cores (Gene Analysis Core, Integrative Morphology Core, and Stem Cell/Organoid Core and Genome Editing Core) and by a Clinical Component of the Administrative Core to facilitate patient-based research. Collectively the Cores and the Clinical Component form a powerful infrastructure that fosters the development of personalized and predictive medical approaches based on the genetics and molecular basis of GI disorders, and of therapies that take into account basic mechanisms of disease. Our working model promotes laboratory discoveries to generate translational research opportunities that lead to validation in patient samples and lead to clinical trials. To strengthen digestive disease research, the DHC will foster collaborations among its investigators and investigators from other disciplines. It will also fund highly promising P/F Projects for junior investigators and will sponsor a dynamic Enrichment Program of scientific seminars, workshops and symposia. With these strategies and an exceptionally supportive institution, the DHC is well positioned to catalyze translational research in pediatric digestive disease.