Biodegradable, Biocompatible Pressure Sensitive Adhesives

项目总结/摘要 * 该提案描述了新的可生物降解的、生物相容的压敏粘合剂（PSA）， 用于体内使用的可调粘附强度。因此，这种创新技术克服了电流的限制， PSA仅局部使用，扩大了此类生物材料在患者护理中的应用范围。 为了突出这些新PSA的效用，我们确定了两个重要的和有问题的临床程序， 胸外科手术与医疗保健费用增加和高死亡率相关：修复肺泡- 和支气管胸膜瘘如今，由于在封闭空间中使用， 瘘管内的压力梯度存活率与瘘管成功闭合直接相关， 预防胸膜感染通过瘘。具体来说，我们正在评估新的聚（1，2-甘油酸 聚碳酸酯）和聚（1，2-甘油碳酸酯）（PGCs），其在功能上模拟常规聚丙烯酸酯PSA 但具有可生物降解的碳酸酯键并降解成良性产物-例如，甘油二氧化碳乙醇 这些第一种聚合物提供了一个机会，创造一个新的公益广告类和改变范式 我们控制和处理胸内伤口的能力。这些实验将测试hy- 这些基于PGC的压敏粘合剂将：1）表现出组成依赖性， 粘合强度与更大的分子量、更长的烷基链和 立构规整性; 2）显示出剥离强度，其可以在从便利贴到 Duct®胶带般的性能;以及，3）能够将胶原蛋白支撑物固定到外科吻合器或 用于密封肺和支气管损伤的电纺聚乳酸网状补片。重要的是，初步数据 支持这些假设，并建立了良好的表征材料和严格的实验设计 在这项提案中，我们需要必要的跨学科合作和专业知识。这五年的具体目标 建议是：目标1。合成并表征一系列PGC基压敏胶;目的2. 在体外和体内评价PGC-粘附性胶原蛋白和PLA贴剂的相容性，并抑制 体外细菌迁移;和，目的3.评价PGC-粘性胶原蛋白和PLA补片的性能 在体内猪模型中。

PROJECT SUMMARY/ABSTRACT * This proposal describes new biodegradable, biocompatible pressure sensitive adhesives (PSAs) with tunable adhesion strength for in vivo use. Thus, this innovative technology overcomes the limitation of current PSAs which are only used topically and broadens the scope of applications of such biomaterials in patient care. To highlight the utility of these new PSAs, we identified two significant and problematic clinical procedures in thoracic surgery associated with increases in health care costs and high mortality rates: the repair of alveolar- and broncho- pleural fistulae. Today, closure of such leaks is challenging due to use in a contained space and to an inherent pressure gradient across the fistula. Survival is directly related to successful fistula closure and prevention of pleural infection through the fistula. Specifically, we are evaluating novel poly(1,2-glyceric acid carbonate)s and poly(1,2-glycerol carbonate)s (PGCs) which functionally mimic conventional polyacrylate PSAs but possess biodegradable carbonate linkages and degrade into benign products – e.g., glycerol, CO2, ethanol. These first-of-their-kind polymers provide an opportunity to create a new class of PSAs and shift the paradigm around our ability to control and manage intrathoracic wounds. The proposed experiments will test the hy- potheses that these PGC based pressure sensitive adhesives will: 1) exhibit compositionally dependent adhesive strength which positively correlates with greater molecular weight, longer alkyl chains, and stereoregularity; 2) display peel strengths which can be tuned over a wide range from Post-it® note to Duct® Tape like performance; and, 3) enable securing a collagen buttress to a surgical stapler or an electrospun polylactide mesh patch for sealing lung and bronchial injuries. Importantly, preliminary data support these hypotheses, and well-characterized materials and rigorous experimental designs are established in this proposal with essential cross-disciplinary collaborations and expertise. The specific aims of this five-year proposal are: Aim 1. Synthesize and characterize a series of PGC-based pressure sensitive adhesives; Aim 2. Evaluate the compatibility of the PGC-adhesive collagen and PLA patch in vitro and in vivo, and inhibition of bacteria migration in vitro; and, Aim 3. Evaluate the performance of the PGC-adhesive collagen and PLA patch in an in vivo porcine model.