Developing standardized graphic libraries for anatomy: A focus on human craniofacial anatomy and phenotypes

开发解剖学标准化图形库：关注人类颅面解剖学和表型

基本信息

批准号：
10442725
负责人：
Melissa Clarkson
金额：
$ 35.52万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10442725
关键词：
Address Adult Anatomy Animal Model Clinical Clinical Data Clinical Medicine Clinical Research Collection Communication Complement Complex Computer software Computers Correlation Studies Custom Data Set Developmental Anatomy Documentation Education Environment Evaluation Face Future Genotype Head Human Informatics Libraries Measurement Medical Education Medical Illustration Medical Research Medicine Methods Morphology Nature Online Systems Ontology Patient Care Patients Persons Phenotype Physical Anthropology Play Population Positioning Attribute Production Research Role Severities Site Standardization Terminology Text Time Variant Visual Work base clinical application clinical practice congenital anomaly craniofacial design malformation multidisciplinary next generation orofacial cleft preservation prototype real world application skills tool tool development vector web-based tool

项目摘要

Project summary Communicating about anatomical concepts and patient-specific anatomy is fundamental to medicine. Anatomy of the head and face (craniofacial anatomy) is complex, and facial morphology varies within and among populations. Orofacial clefts—which are among the most common congenital anomalies— display a range of severities and may be preset at more than one site. There is a need to communicate rapidly and accurately about craniofacial anatomy in clinical practice, medical education, and when using clinical data in research. To address this challenge, we propose to create simple, standardized graphics of craniofacial anatomy and phenotypes. Our collections of graphics, or “graphic libraries”, will serve as complements to textual representations and will be designed for use within clinical, research, and educational software applications. Our approach to designing the graphics is based on four requirements: that the graphics be composable, extensible, identifiable, and created using scalable vector graphics (SVGs). We will first develop graphics for adult and developmental anatomy, then for phenotype variations and malformations. We will also develop prototypes for two web-based tools—one that incorporates graphics into the Human Phenotype Ontology and the other for documenting craniofacial phenotypes and malformations in clinical settings. By offering a new paradigm for communicating about anatomy, our graphic libraries will become crucial components of the next generation of software applications for clinical practice, research, and education.

项目摘要沟通有关解剖概念和特定于患者的解剖学是医学的基础。头部和脸部解剖（颅面解剖结构）很复杂，面部形态学多种和人口中。口面裂口（最常见的先天异常之一）显示一系列严重性，可以在一个以上的站点上预设。有必要在临床上快速，准确地进行有关颅面解剖结构的沟通练习，医学教育以及在研究中使用临床数据时。为了应对这一挑战，我们提议创建颅面解剖结构和表型的简单标准化图形。我们的收藏图形或“图形库”将作为文本表示的完整设计用于临床，研究和教育软件应用。我们的方法设计图形是基于四个要求的：图形是可综合的，可扩展的，可识别，并使用可扩展的向量图形（SVG）创建。我们将首先开发成人和发育解剖学的图形，然后为表型变化和畸形。我们还将为两个基于网络的工具开发原型 - 一种合并用于人类表型本体的图形，另一种用于记录颅面表型的图形和临床环境中的畸形。通过提供新的范式来沟通解剖学，我们的图形库将成为下一代软件应用程序的关键组成部分临床实践，研究和教育。