Midcareer Investigator Award in Patient-Oriented Research in the Microbiome and Lung Disease

微生物组和肺部疾病以患者为导向的研究中的职业生涯中期研究员奖

基本信息

批准号：
10446663
负责人：
Robert Pickett Dickson
金额：
$ 12.5万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-01 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10446663
关键词：
2019-nCoV Acute American Antibiotics Area Attenuated Vaccines Award Bacterial DNA Biological Bleomycin Blood Blood specimen COVID-19 COVID-19 patient Career Mobility Cells Cessation of life Clinical Collaborations Communication Communities Critical Care Critical Illness Development Development Plans Disease Enrollment Faculty Fellowship Program Functional disorder Goals Heterogeneity Human Hypoxemic Respiratory Failure Immune Immune response Immunity Immunologics Immunology Immunophenotyping Influenza Influenza vaccination Intestinal permeability Journals Leadership Leukocytes Lung Lung diseases Manuscripts Measurement Measures Mechanics Medical Students Medicine Mentors Mentorship Metabolic Metagenomics Methodology Michigan Microbiology Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Morbidity - disease rate Multiple Organ Failure Nose Organ Oropharyngeal Outcome Oxygen Pathogenesis Patients Persons Phenotype Physicians Plasma Predisposition Prevention Proteomics Publications Reporting Research Research Methodology Research Personnel Research Support Risk Factors Role SARS coronavirus SARS-CoV-2 infection Scientist Secure Severities Source Specimen Supervision Swab Symptoms Therapeutic Time TimeLine Training Training Programs Translational Research Universities Upper respiratory tract Variant Ventilator Viral Respiratory Tract Infection Virus Diseases career community living comorbidity density experimental study gut bacteria gut microbiota healthy volunteer human model immune activation indexing influenza infection interest lung injury lung microbiota metabolomics microbial community microbiome microbiome research microbiota mid-career faculty modifiable risk mortality multidisciplinary next generation novel oropharyngeal swab patient oriented patient oriented research patient variability prognostic programs prospective recruit rectal research and development respiratory respiratory microbiota respiratory virus responsible research conduct severe COVID-19 skills therapeutic target

项目摘要

PROJECT SUMMARY/ABSTRACT Dr. Dickson is an Associate Professor in Medicine (Pulmonary & Critical Care Medicine) and Microbiology & Immunology at the University of Michigan. He is a physician-scientist with expertise in the microbiome’s role in critical illness and lung disease, and has an established track record of high-impact patient-oriented research. He has demonstrated his potential to excel in mentorship via successful supervision of research trainees, as Associate Program Director for Research for the University of Michigan’s highly successful Pulmonary & Critical Care Medicine Fellowship Program, and as Associate Program Director for his Division’s T32 training program (Multidisciplinary Training in Lung Disease). Dr. Dickson seeks this K24 Mid-Career Investigator Award to continue his successful research program while dedicating significant time to mentoring the next generation of aspiring scientists, including medical students, residents, clinical and post-doctorate fellows, and junior faculty. The goals of this proposal are to 1) support the candidate’s continued impact as a mentor, 2) secure protected time for coursework to acquire new mentorship and leadership skills, 3) and equip the candidate to recruit mentees interested in patient-oriented research. In his proposed research and development plan, Dr. Dickson will tailor a mentoring plan to each trainee consisting of one-on-one mentoring sessions, formal educational opportunities in research methods and the responsible conduct of research, and collaborations with colleagues with complementary expertise and educational commitments. Each candidate will have a tailored timeline towards career advancement, including the regular publication of original research manuscripts. Dr. Dickson will provide mentorship not only in methodologic expertise but also in the critical skills of scientific communication and leadership. Dr. Dickson’s scientific aims for this project will extend his existing research into a new area of immediate patient-oriented importance: the role of the microbiome in viral respiratory infections. The first aim will be to determine if respiratory and gut bacteria (characterized via pharyngeal swabs, rectal swabs, and by the diversity and burden of gut bacterial DNA detectable in blood specimens) explains patient heterogeneity in susceptibility to severe COVID-19 disease. The second aim will be to determine how acute influenza infection and vaccination (administered in a controlled experiment of healthy volunteers) alters upper respiratory tract microbiota, and how this explains variation in systemic immune response. These aims leverage 1) existing biospecimens already available to Dr. Dickson, 2) a unique controlled experimental human model of acute influenza infection, and 3) Dr. Dickson’s broad research portfolio characterizing the role of microbiota (both respiratory and gut) in the pathogenesis of critical illness. Dr. Dickson is at an ideal stage of his career to take advantage of a K24 award, and is deeply committed to an investigative career in patient-oriented research as well as developing the next generation of investigators.

项目摘要/摘要迪克森博士是医学副教授（肺和重症医学）和微生物学和密歇根大学免疫学。他是一位身体科学家，在微生物组中具有专业知识危害疾病和肺部疾病，并具有高影响患者的研究的既定记录。他已经通过成功监督研究受训者表现出了自己在Mentalship中表现出色的潜力，密歇根大学非常成功的肺部研究副计划主任重症监护医学奖学金计划，作为其部门T32培训的副计划主任计划（肺部疾病的多学科培训）。 Dickson博士寻求K24中级研究员奖，以继续他的成功研究计划奉献精神大量时间来使下一代有抱负的科学家，包括医学生，居民，临床和后cittorate研究员以及初级教师。该提议的目标是1）支持候选人作为心理的持续影响，2）确保受保护的课程获得新心态的时间 3）和领导技能，并装备候选人在以患者为导向的研究中招募有趣的培训。迪克森博士在他提出的研发计划中，将为每个受训者量身定制一个心理计划由一对一的心理课程，研究方法中的正规教育机会和负责任的研究以及与同事具有完善专业知识的合作教育承诺。每个候选人将有一个量身定制的时间表，包括定期出版原始研究手稿。迪克森博士不仅将提供精神训练方法论专业知识，以及科学沟通和领导力的关键技能。迪克森博士对该项目的科学目标将把他的现有研究扩展到一个新的立即的领域面向患者的重要性：微生物组在病毒呼吸道感染中的作用。第一个目标是确定呼吸道和肠道细菌是否（通过咽拭子，直肠拭子以及通过肠道细菌的多样性和燃烧在血液样本中可检测到的DNA）解释了患者的异质性对严重的Covid-19疾病的敏感性。第二个目的是确定急性影响力感染和疫苗接种（在健康志愿者的受控实验中进行给药）改变了上呼吸道微生物群，以及这如何解释全身免疫反应的差异。这些目标杠杆作用1）现有 Dickson博士已经可以使用的生物测量，2）一种独特的受控实验人类急性模型流感感染和3）迪克森博士的广泛研究组合，表征了微生物群的作用（两者都呼吸道和肠道）在危重疾病的发病机理中。迪克森博士正处于利用K24奖的理想阶段，并深深地致力于以患者为导向的研究以及发展下一代研究人员的调查生涯。