Prevention of Developmental Delay and Xylitol (PDDaX) Study

预防发育迟缓和木糖醇 (PDDaX) 研究

基本信息

  • 批准号:
    10447994
  • 负责人:
  • 金额:
    $ 16.01万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-06-09 至 2027-05-31
  • 项目状态:
    未结题

项目摘要

Globally, 15 million preterm births occur annually, with the majority born in low- and middle-income countries. Prematurity is a leading cause of both under-5 mortality and future neurodevelopmental delay. A long- established link between periodontal disease and preterm birth exists, yet common dental interventions such as scaling and planing fail to prevent preterm birth. Xylitol, a sugar substitute commonly found in gum products, prevents caries and periodontitis with presumed dampening of local and systemic inflammation, a risk factor for neurodevelopmental delay in offspring. We recently completed a cluster-randomized trial in Malawi designed to test the efficacy of xylitol gums to prevent preterm birth and immediate neonatal outcomes. This follow-up study proposal seeks to meaningfully advance our findings by evaluating if exposure to xylitol gum administered preconception or during early pregnancy improves neurodevelopmental outcomes in offspring (up to 6 years of age). Specifically, we will test the hypothesis by formally evaluating whether chewing xylitol gum prevents adverse neurodevelopmental outcomes by leveraging subjects from the Prevention of Prematurity and Xylitol (PPaX) Trial that enrolled 10,404 pregnant women in Malawi from 2015-2019. The Specific Aims of the research are to: 1) Evaluate the sensitivity and specificity of the MDAT as compared to the KABC-II neurodevelopment diagnostic tool in assessing neurodevelopmental delay of formerly term children aged 4-6 years of age; 2) Evaluate the sensitivity and specificity of the MDAT as compared to the KABC- II in assessing neurodevelopmental delay of formerly preterm children aged 4-6 years of age; 3) Determine the impact of xylitol gum exposure during pregnancy on the neurodevelopmental outcomes of 200 sex-matched term born children (100 controls, 100 xylitol) and 200 preterm born children (100 controls, 100 xylitol). Validating the MDAT by comparing it to the KABC-II neurodevelopmental assessment in former preterm and term neonates in Malawi will allow for more efficient, cost-effective studies in the future and build capacity in low-resourced settings to identify children with neurodevelopmental delay more easily and provide more timely intervention. If xylitol use during pregnancy is found to prevent neurodevelopmental delay in offspring, this low-cost solution will prove to be a game-changer in preventing neurodevelopmental delay worldwide. Proposed Career and Learning Objectives are to: 1) Attain advanced skills in epidemiology, study design, data management, and analytic methods to correctly implement research focusing on evaluating neonatal outcomes in settings of health disparities, and 2) Enhance skills in database development, scientific writing, presentations, and grant preparation, and 3) Attain advanced skills, including neurodevelopmental test selection, examiner training and oversight, test interpretation and knowledge needed to conduct rigorous neurodevelopmental outcomes research. These skills will facilitate the applicant’s cutting-edge research on perinatal interventions to improve neonatal health and future neurodevelopmental outcomes in the most vulnerable populations.
全球每年发生1500万例早产,其中大多数出生在低收入和中等收入国家。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Gregory Charles Valentine其他文献

Gregory Charles Valentine的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Gregory Charles Valentine', 18)}}的其他基金

Prevention of Developmental Delay and Xylitol (PDDaX) Study
预防发育迟缓和木糖醇 (PDDaX) 研究
  • 批准号:
    10636847
  • 财政年份:
    2022
  • 资助金额:
    $ 16.01万
  • 项目类别:

相似海外基金

Psychosocial factors as potential moderators of the association between prenatal stress from the Fort McMurray wildfire and social emotional development in 5-6 year old children
心理社会因素作为麦克默里堡野火产前压力与 5-6 岁儿童社会情绪发展之间关系的潜在调节因素
  • 批准号:
    467237
  • 财政年份:
    2021
  • 资助金额:
    $ 16.01万
  • 项目类别:
    Studentship Programs
Mechanisms of Sustained Selective Attention in 2- to 6- Year-Old Children
2至6岁儿童持续选择性注意力的机制
  • 批准号:
    7739271
  • 财政年份:
    2009
  • 资助金额:
    $ 16.01万
  • 项目类别:
Stage 1 Treatment Development with Homeless Mothers and their 2-6 Year Old Childr
无家可归的母亲及其 2-6 岁儿童的第一阶段治疗发展
  • 批准号:
    7627037
  • 财政年份:
    2009
  • 资助金额:
    $ 16.01万
  • 项目类别:
Mechanisms of Sustained Selective Attention in 2- to 6- Year-Old Children
2至6岁儿童持续选择性注意力的机制
  • 批准号:
    7921601
  • 财政年份:
    2009
  • 资助金额:
    $ 16.01万
  • 项目类别:
Stage 1 Treatment Development with Homeless Mothers and their 2-6 Year Old Childr
无家可归的母亲及其 2-6 岁儿童的第一阶段治疗发展
  • 批准号:
    8037547
  • 财政年份:
    2009
  • 资助金额:
    $ 16.01万
  • 项目类别:
Stage 1 Treatment Development with Homeless Mothers and their 2-6 Year Old Childr
无家可归的母亲及其 2-6 岁儿童的第一阶段治疗发展
  • 批准号:
    8035834
  • 财政年份:
    2009
  • 资助金额:
    $ 16.01万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了