A longitudinal study of Puerto Rican children and the impact of adverse childhood experiences on the development of cognitive control and risk for substance use disorders

对波多黎各儿童的纵向研究以及不良童年经历对认知控制发展和物质使用障碍风险的影响

• 批准号: 10451522
• 负责人: Tamara Sussman
• 金额: $ 19.6万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10451522
• 关键词: Acculturation; Adolescent; Adult; American; Automobile Driving; Award; Behavior; Behavioral; Biological; Brain; Brain region; Child; Child Health; Childhood; Cognitive; Collection; Communities; Computer Models; Conflict (Psychology); Data; Data Set; Decision Making; Development; Diffusion; Disadvantaged; Drug Addiction; Drug usage; Enrollment; Ensure; Environment; Exposure to; Family; Fibrinogen; Fostering; Functional Magnetic Resonance Imaging; Future; Goals; Human; Impulsivity; Intervention; Lead; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mentorship; Minority Groups; Modeling; National Institute of Drug Abuse; Neurobiology; Outcome; Outcome Study; Participant; Patient Self-Report; Pattern; Performance; Personality; Population; Prevention; Prevention approach; Prevention strategy; Process; Puerto Rican; Reaction Time; Reporting; Research; Research Personnel; Research Training; Rest; Risk; Risk Factors; Sampling; Structure; Substance Use Disorder; Task Performances; Time; Training; Treatment outcome; United States National Institutes of Health; Youth; adverse childhood events; aged; authority; base; brain behavior; career development; cognitive control; cognitive development; cognitive neuroscience; cognitive task; cohort; disorder risk; experience; follow up assessment; improved; indexing; insight; intergenerational; longitudinal design; minority children; neurobehavioral; neurodevelopment; novel; novel strategies; programs; prospective; relating to nervous system; response; sex; social culture; substance use; theories

PROJECT SUMMARY This K08 application aims to characterize how exposure to adverse childhood experiences (ACEs) changes sub-components of cognitive control, related brain function, and substance use disorder (SUD) risk. Improved understanding of the impact of ACEs on cognitive control and SUD risk is of particular importance in the Puerto Rican community, as this group has higher rates of ACEs and worse SUD treatment outcomes than the general US population, and is underrepresented in SUD and neurobiological studies. This five-year K08 application presents a program for research and training that will support the applicant on a path towards becoming an independent investigator, focused on studying the development of SUD risk using a developmental cognitive neuroscience approach. The training plan builds on the candidate's prior experience and training and capitalizes on an outstanding mentorship team and research environment to foster the development of the candidate's expertise in (1) collection, analysis and interpretation of longitudinal pediatric fMRI data; 2) SUD risk in a pediatric minority population; (3) computational modeling of cognitive and neuro- developmental processes; (4) responsible conduct of scientific research. This project will investigate the influence of ACEs on the development of sub-components cognitive control and related brain activity in the frontoparietal (FPN) and cingulo-opercular (CON) networks during a cognitive control performance task and at rest (Aim 1), and the relationship between ACE-related changes in development and SUD risk (Aim 2). We hypothesize that increased ACEs will lead to (1) a slower rate of evidence accumulation (i.e. drift rate, a computational model parameter), (2) greater activity in key FPN nodes, and (3) increased connectivity between FPN and CON nodes and other regions. Furthermore, these behavioral and neural changes will be associated with increased risk for SUD. Currently, the proposed study participants are enrolled in the NIH Environmental influences on Child Health Outcomes (ECHO) study, which will collect cognitive control measures and MRI data on 290 children. Building on this structure, we propose to select a subsample (n=76) of children, evenly sampled across the full range of baseline cumulative ACE scores, and invite them to participate in a follow up assessment. Measures of cognitive control performance, brain activity during cognitive task performance and rest, and parental- and self-report of SUD-risk related behaviors will be collected. Data yielded from the proposed study will lead to a future R01 application examining continued development of cognitive control, brain activity and SUD risk, as well as the development of substance use patterns and SUD as these children become adolescents. Together, the research and training experiences and expertise developed through this K08 award will support the applicant's transition to research independence and ensure the applicant becomes a leading authority in the developmental cognitive neuroscience of SUD risk, focusing on the impact of ACEs.

项目总结 这个K08应用程序旨在描述暴露在不良童年经历(ACE)中的变化 认知控制、相关大脑功能和物质使用障碍(SUD)风险的子组成部分。改进 了解ACE对认知控制和sud风险的影响在波多黎各尤为重要。 Rican社区，因为这一群体的ACE发生率较高，而SUD治疗结果较差 美国普通人群，在SUD和神经生物学研究中代表性不足。这个五年期的K08 申请提出了一项研究和培训计划，将支持申请者走上 成为一名独立的调查员，专注于使用 发展认知神经科学方法。培训计划建立在应聘者以前的经验基础上 和培训，并利用优秀的指导团队和研究环境来促进 培养候选人在以下方面的专长：(1)收集、分析和解释纵向儿科 FMRI数据；2)儿童少数民族人群中的SUD风险；(3)认知和神经功能障碍的计算模型。 发展过程；(4)负责任的科学研究行为。该项目将调查 ACEs对大鼠认知控制亚组分发展及相关脑活动的影响 认知控制操作任务中的额顶叶(FPN)和扣带盖(CON)网络 REST(目标1)，以及与血管紧张素转换酶相关的发育变化与SUD风险之间的关系(目标2)。我们 假设增加的ACE将导致(1)较慢的证据积累速度(即漂移率， 计算模型参数)，(2)关键FPN节点中的更大活动，以及(3)增加 FPN和CON节点等区域。此外，这些行为和神经变化将与 增加了罹患SUD的风险。目前，建议的研究参与者登记在美国国立卫生研究院环境研究所 对儿童健康结果的影响(ECHO)研究，将收集认知控制措施和核磁共振 290名儿童的数据。在这个结构的基础上，我们建议均匀地选择儿童的一个子样本(n=76) 对所有基准累计ACE分数进行抽样，并邀请他们参与后续调查 评估。测量认知控制绩效、认知任务绩效中的大脑活动和 休息时间，以及父母和自我报告的SUD风险相关行为将被收集。生成的数据 拟议的研究将导致未来的R01应用程序检查认知控制的持续发展， 这些儿童的大脑活动和SUD风险，以及物质使用模式和SUD的发展 成为青少年。总而言之，通过这种方式开发的研究和培训经验和专业知识 K08奖项将支持申请者向研究独立的过渡，并确保申请者成为 SUD风险的发展认知神经科学的领先权威，专注于ACE的影响。