The Impact of Insufficient Sleep and Insomnia Disorder on Behavioral and Neural Markers of Emotion Regulation

项目摘要 健康的运作需要管理我们情绪的能力。越来越多的证据表明， 睡眠通过维持优化情绪所需的神经回路，在这种适应过程中起着至关重要的作用 调控此外，慢性睡眠中断是一种常见的特征，并且可能是睡眠障碍的潜在原因。 许多以情绪和情感调节受损为特征的精神疾病，如抑郁症。的 这种关系的后果变得更加可怕，因为人们认识到，慢性睡眠中断 自杀的风险会增加一倍拟议研究的目的是确定重叠和 患者的临床失眠和健康对照中多晚睡眠不足对睡眠质量的影响不同 情绪调节任务中的行为和神经反应。我的主要假设是临床睡眠 干扰和多个夜晚的睡眠中断都破坏了成功情绪所需的电路 调节，因此是情绪功能失调的关键驱动因素。主要理由 我们对睡眠中断和情绪功能之间关系的理解， 依赖于单夜，急性睡眠剥夺或大样本趋势的评估， 在理解长期、慢性睡眠不足对情绪调节的机械影响方面存在差距。这 要了解不同形式的睡眠中断对情绪的影响程度， 和情绪失调的症状在拟议的研究中，我将招募以下患者： 失眠症（ID; n=25）和经历正常睡眠（n=25）或睡眠限制的健康个体 （n=25）方案。所有参与者将在两种情况下完成情绪调节范式，一次是作为一个 基线，第二次在功能性磁共振成像（fMRI）期间。我预测当雇佣 对厌恶性刺激、睡眠受限的参与者和ID患者的情绪调节策略在很大程度上 重叠的行为和神经网络结果，包括意志性地减少负面影响的能力受损 行为反应，杏仁核过度活跃，以及杏仁核和 前额皮质这项研究是确定行为和神经后果的必要下一步， 慢性睡眠中断对有效调节情绪的能力的影响，然后可以将其用作 开发新的疗法。我的培训计划熟练地补充了技术和理论方面的内容 需要成功地导航拟议的项目和我未来的研究轨迹。选定的活动 将提供机会，发展纵向睡眠研究，功能磁共振成像数据处理设计的专业知识， 和分析，对精神障碍及其与精神病表现的关系的理论理解， 以及如何设计和实施大规模RCT。通过这个奖项，我将获得必要的数据， 接受培训，使自己成为独立调查员，并为将来的R 01提交调查做准备 由于睡眠中断导致的情绪失调的差异与许多精神疾病有关。

PROJECT SUMMARY Healthy functioning necessitates an ability to manage our emotions. A growing body of evidence suggests that sleep plays a crucial role in this adaptive process by maintaining the neural circuitry required to optimize emotion regulation. Further, chronically disrupted sleep is a common feature and potentially an underlying cause of a number of psychiatric disorders marked by impaired mood and emotion regulation, such as depression. The consequences of this relationship become even more dire with the recognition that chronic sleep disruption more than doubles the risk of suicide. The objective of the proposed study is to determine the overlapping and differential impact of clinical insomnia in patients and multiple nights of insufficient sleep in healthy controls on behavioral and neural responses during an emotion regulation task. My central hypothesis is that clinical sleep disturbance and multiple nights of truncated sleep both disrupt the circuitry needed for successful emotion regulation, and therefore are critical drivers in the dysregulation of emotional functioning. The primary rationale is that a vast majority of our understanding of the relationship between disrupted sleep and emotion function has relied either on single-night, acute sleep deprivation or assessment of trends in large samples, leaving a major gap in understanding the mechanistic impact of longer, more chronic sleep loss on emotion regulation. This information is essential to understand the degree to which different forms of disrupted sleep account for mood and emotion dysregulation in a host of psychiatric conditions. In the proposed study, I will recruit patients with Insomnia Disorder (ID; n=25) and healthy individuals that undergo a normal sleep (n=25) or sleep restriction (n=25) protocol. All participants will complete an emotion regulation paradigm on two occasions, once as a baseline, and a second time during functional magnetic resonance imaging (fMRI). I predict that when employing emotion regulation strategies to aversive stimuli, sleep restricted participants and ID patients will have largely overlapping behavioral and neural network outcomes, including impaired ability to volitionally reduce negative behavioral responses, amygdala hyperactivity, and weaker negative connectivity between the amygdala and prefrontal cortex. The study is a necessary next step in determining the behavioral and neural consequences of chronic sleep disruption on the ability to effectively regulate emotions, which can then be used as targets for the development of new therapies. My training plan adeptly complements both the technical and theoretical aspects needed to successfully navigate the proposed project and my trajectory of future research. The selected activities will provide the opportunity to develop expertise in the design of longitudinal sleep studies, fMRI data processing and analysis, theoretical understanding of Insomnia Disorder and its relationship to psychiatric presentations, and how to design and implement large-scale RCTs. Through this award, I will receive the necessary data and training to establish myself as an independent investigator and prepare for future R01 submissions investigating the variance in emotional dysregulation due to sleep disruption relevant to a host of psychiatric conditions.