TSSK-dependent signaling pathway in spermatogenesis
精子发生中 TSSK 依赖性信号通路
基本信息
- 批准号:10450404
- 负责人:
- 金额:$ 16.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-01 至 2023-11-30
- 项目状态:已结题
- 来源:
- 关键词:AffectBiochemical GeneticsBiological AssayBiological ModelsBiologyCell LineCellsCytoplasmDataDefectDevelopmentDrosophila genusExclusionFamilyFemaleFertilityFertilizationFertilization in VitroFishesGeneticGenetic EpistasisGenetic ScreeningGenomeGoalsHDAC4 geneHistone DeacetylaseHumanIn VitroInheritedInsectaIntracytoplasmic Sperm InjectionsKnowledge ManagementLeadMale InfertilityMammalian CellMammalsMusNuclearPathway interactionsPatternPharmaceutical PreparationsPhenotypePhosphorylationPhosphotransferasesPhysiologicalPopulationProceduresProcessProductionProtein-Serine-Threonine KinasesReptilesResearchRoleSexual ReproductionSignal PathwaySignal TransductionSpermatogenesisTestisTherapeuticVeinsWingeggexperimental studyflygenetic approachgermline stem cellsin vitro activityin vivoinsightkinase inhibitorloss of functionmalemembermutantnew therapeutic targetnovelnucleocytoplasmic transportoffspringself-renewalsperm celltargeted treatmenttrait
项目摘要
ABSTRACT
Testis-specific serine kinases (TSSKs) belong to AMPK-related kinase family. Loss-of-function mutants of some
TSSK members lead to spermatogenesis defects in male mice, and several SNPs of TSSKs are associated with
male infertility in humans. However, the TSSK signaling mechanism during spermatogenesis is not understood.
This proposal employs Drosophila as a model system to investigate a novel kinase-substrate pair: TSSKs-class
IIa HDACs. Aim 1 will determine whether class IIa HDACs are substrates of TSSKs using both biochemical and
genetic approaches. Aim 2 will explore the functional relevance of TSSKs-class IIa HDACs during
spermatogenesis in Drosophila. Collectively, this proposal will establish class IIa HDACs as the key downstream
component of TSSK signaling.
摘要
睾丸特异性丝氨酸激酶(TSSKs)属于AMPK相关激酶家族。一些功能缺失的突变体
TSSK成员导致雄性小鼠精子发生缺陷,TSSK的几个SNPs与
人类中的男性不育。然而,精子发生过程中的TSSK信号机制尚不清楚。
该方案使用果蝇作为模型系统来研究一种新的激酶-底物对:TSSKs类
IIa HDAC。目标1将确定IIa类HDAC是否为TSSK的底物,使用生化和
遗传方法。目标2将探讨TSSKs-Class IIa HDAC在
果蝇的精子发生。总的来说,这项提议将建立IIa类HDAC作为关键的下游
TSSK信令的组件。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Biao Wang', 18)}}的其他基金
Regulation of beige adipocyte plasticity in inguinal white adipose tissue.
腹股沟白色脂肪组织中米色脂肪细胞可塑性的调节。
- 批准号:
10563617 - 财政年份:2023
- 资助金额:
$ 16.15万 - 项目类别:
Ucp1-independent functions in brown and beige adipocytes
棕色和米色脂肪细胞中独立于 Ucp1 的功能
- 批准号:
10365709 - 财政年份:2021
- 资助金额:
$ 16.15万 - 项目类别:
Ucp1-independent functions in brown and beige adipocytes
棕色和米色脂肪细胞中独立于 Ucp1 的功能
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10532159 - 财政年份:2021
- 资助金额:
$ 16.15万 - 项目类别:
Transcriptional control in brown and beige adipocytes
棕色和米色脂肪细胞的转录控制
- 批准号:
8984492 - 财政年份:2015
- 资助金额:
$ 16.15万 - 项目类别:
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