Improving Outcomes Assessment for Microbial Keratitis
改善微生物角膜炎的结果评估
基本信息
- 批准号:10449703
- 负责人:
- 金额:$ 22.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-01 至 2027-03-31
- 项目状态:未结题
- 来源:
- 关键词:AffectAnatomyAnteriorApplied ResearchAreaBiometryBlindnessCategoriesCharacteristicsCicatrixClinicalClinical MicrobiologyClinical ResearchClinical TrialsClinical assessmentsConduct Clinical TrialsCorneaCorneal DiseasesCorneal UlcerDataDensitometryDiseaseEducational workshopEnrollmentEnvironmentEvidence based treatmentEvolutionFundingFutureGoalsHeterogeneityImmersionIndiaIndividualInfectionK-Series Research Career ProgramsKeratitisMeasurementMeasuresMentorsMentorshipMethodologyModalityModelingMonitorMulti-Institutional Clinical TrialMultimodal ImagingNatural HistoryOptical Coherence TomographyOpticsOutcomeOutcome AssessmentPatientsPersonsPopulationPrognosisProspective StudiesProspective cohort studyQuality of lifeReproducibilityResearchSample SizeScientistSeveritiesStatistical ModelsStatistical StudyStratificationStructureSubgroupThinnessTimeTrainingTreatment EfficacyUniversitiesVisionVisualVisual Acuitycareer developmentclinical applicationclinical careclinical practiceclinical trial implementationclinically relevantcohortcomparative efficacycomparison groupcorneal scardensitydesignexperiencefollow-uphealth care settingsimaging modalityimprovedimproved outcomeinnovationinsightmicrobialnew technologynovelpatient populationprospectiverandomized trialresearch studyslit lamp imagingsugartomographytreatment responseultrasound
项目摘要
ABSTRACT
The overarching research goal of this K23 Mentored Career Development Award is to improve outcomes
assessment for microbial keratitis (MK), or infectious corneal ulceration. MK affects 2 million people per year
and causes significant harm to vision and quality of life. Meaningful measurement of MK for clinical and
research purposes remains challenging. Traditional clinical assessments of MK severity and response to
treatment are subjective and imprecise, making it difficult to compare efficacy of treatments in clinical research
studies due to low reproducibility and increased sample size requirements. Prior MK clinical trials have used
outcome metrics such as best spectacle-corrected visual acuity which are not disease-specific and may fail to
capture key information about corneal damage caused by MK. These measurement limitations reduce the
quality and impact of MK research. To date, most large-scale prospective randomized trials in MK have failed
to demonstrate clinically meaningful or statistically significant differences in treatment response between
groups. Single-center MK studies can also lack applicability to other healthcare settings due to differences in
patient characteristics and microbial distributions across populations. Developing more objective, reproducible,
clinically relevant, and generalizable outcome metrics and predictors for MK would enhance the clinical
relevance and statistical power of future multicenter MK studies. New imaging modalities such as Scheimpflug
tomography and anterior segment optical coherence tomography (ASOCT) can provide objective, precise,
reproducible, and clinically relevant assessments of corneal structure, but these modalities have not been
critically evaluated for MK clinical care or research using prospective studies. This application proposes to
conduct a prospective cohort study of MK patients at Johns Hopkins. We will collect detailed clinical and
microbiologic data and perform serial multimodal imaging using slit lamp photography, Scheimpflug
tomography, and ASOCT over 6 months. Aim 1 will compare the reproducibility and concordance of ultrasound
pachymetry, Scheimpflug tomography, and ASOCT for objective quantification of corneal thinning in MK. Aim 2
will evaluate Scheimpflug densitometry as a means of objectively quantifying longitudinal changes in corneal
scar density in MK. Aim 3 will assess whether certain early anatomic or clinical features can improve prediction
of subsequent visual outcomes in MK and whether these predictors are applicable across different MK
populations and infection subgroups, indicating the suitability of these novel outcome metrics for use in
collaborative multicenter clinical trials. This proposal will provide the candidate with the advanced training and
research experience needed to become an expert in clinical trials methodology and an independently funded
clinician-scientist in the field of cornea and external diseases. The candidate proposes a comprehensive
training plan combining rigorous formal coursework, seminars, and workshops in the intellectually rich
environment at Johns Hopkins University; world-class mentorship under Drs. Douglas Jabs, Thomas Lietman,
Elizabeth Sugar, and Albert Jun; immersive experience with ongoing prospective multicenter clinical trials; and
applied research experience. Specific training areas include: (1) advanced clinical trial methodology; (2)
practical clinical trial implementation; (3) advanced biostatistics; (4) clinical and research expertise in microbial
keratitis; and (5) career development as a clinician-scientist. Results from the candidate’s research will be used
to develop a proposal for a R01 or UG1 funded clinical trial that will improve evidence-based treatment for
cornea and external diseases.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Nakul Shekhawat其他文献
Nakul Shekhawat的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Nakul Shekhawat', 18)}}的其他基金
Improving Outcomes Assessment for Microbial Keratitis
改善微生物角膜炎的结果评估
- 批准号:
10630922 - 财政年份:2022
- 资助金额:
$ 22.43万 - 项目类别:
相似海外基金
Linking Epidermis and Mesophyll Signalling. Anatomy and Impact in Photosynthesis.
连接表皮和叶肉信号传导。
- 批准号:
EP/Z000882/1 - 财政年份:2024
- 资助金额:
$ 22.43万 - 项目类别:
Fellowship
Digging Deeper with AI: Canada-UK-US Partnership for Next-generation Plant Root Anatomy Segmentation
利用人工智能进行更深入的挖掘:加拿大、英国、美国合作开发下一代植物根部解剖分割
- 批准号:
BB/Y513908/1 - 财政年份:2024
- 资助金额:
$ 22.43万 - 项目类别:
Research Grant
Simultaneous development of direct-view and video laryngoscopes based on the anatomy and physiology of the newborn
根据新生儿解剖生理同步开发直视喉镜和视频喉镜
- 批准号:
23K11917 - 财政年份:2023
- 资助金额:
$ 22.43万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Genetics of Extreme Phenotypes of OSA and Associated Upper Airway Anatomy
OSA 极端表型的遗传学及相关上呼吸道解剖学
- 批准号:
10555809 - 财政年份:2023
- 资助金额:
$ 22.43万 - 项目类别:
computational models and analysis of the retinal anatomy and potentially physiology
视网膜解剖学和潜在生理学的计算模型和分析
- 批准号:
2825967 - 财政年份:2023
- 资助金额:
$ 22.43万 - 项目类别:
Studentship
Computational comparative anatomy: Translating between species in neuroscience
计算比较解剖学:神经科学中物种之间的翻译
- 批准号:
BB/X013227/1 - 财政年份:2023
- 资助金额:
$ 22.43万 - 项目类别:
Research Grant
Doctoral Dissertation Research: Social and ecological influences on brain anatomy
博士论文研究:社会和生态对大脑解剖学的影响
- 批准号:
2235348 - 财政年份:2023
- 资助金额:
$ 22.43万 - 项目类别:
Standard Grant
Development of a novel visualization, labeling, communication and tracking engine for human anatomy.
开发一种新颖的人体解剖学可视化、标签、通信和跟踪引擎。
- 批准号:
10761060 - 财政年份:2023
- 资助金额:
$ 22.43万 - 项目类别:
Understanding the functional anatomy of nociceptive spinal output neurons
了解伤害性脊髓输出神经元的功能解剖结构
- 批准号:
10751126 - 财政年份:2023
- 资助金额:
$ 22.43万 - 项目类别:
The Anatomy of Online Reviews: Evidence from the Steam Store
在线评论剖析:来自 Steam 商店的证据
- 批准号:
2872725 - 财政年份:2023
- 资助金额:
$ 22.43万 - 项目类别:
Studentship














{{item.name}}会员




