Clinical Translational Core

(CORE B- CTC：临床翻译核心） 项目摘要 描述：临床翻译核心（CTC）提供一套全面的服务，旨在 提高智力和发育障碍临床转化研究的影响力和严谨性 （IDD）。选择服务是新颖的，在CTC之外不可用;其他服务提高了研究效率 加强对所有CT研究共同的研究活动的质量控制。释放个人IDDRC用户的 公共活动的负担反过来又使用户能够更好地部署资源，用于创新和最大化 他们的转化科学的影响。CTC的服务分为四个方面：（1）协助适当组装 大型研究队列，以支持严谨，有力的研究。大样本的招募是必要的， 发育障碍的研究，具有必须测量的各种临床表现， 在数据分析中进行控制，以获得可重现的结果。(2)创建研究专用交互式数据库 和可视化工具，使实验室能够跟踪他们的研究进展，有效地分配资源和努力， 准备研究报告和数据提交（例如，NIMH数据存档）。反恐委员会与 基因组学和数据集成以及神经成像和神经电路核心，支持不同数据的集成 类型(3)支持IRB和IND方案准备、提交和回复规定的所有阶段;以及 为校园内已有的其他免费研究支持提供礼宾服务，例如 由CHOP的临床试验办公室提供，并由Penn/CHOP临床和翻译提供服务 科学奖（CTSA）。(4)专家临床评估支持，包括常规 心理测量;电子健康的生物信息学分析的可计算表型 记录（EHR）;以及使用计算机视觉和计算语言学来实现 语音、语言和可观察行为的粒度测量（例如，非语言的面部表情， 在交互过程中个体之间的同步）。这些技术和分析能力尤其 因为它们在校园或商业上是不可用的。CTC将与临床前 模型核心是动物和人类行为的计算机视觉测量（例如，步态），以获得特征， 绘制跨物种的图谱，以便更快地转化研究结果并验证有前途的治疗方法。 与缺碘症防治中心的相关性使命：中心促进缺碘症的跨学科转化研究和培训 (e.g.,通过与神经发育和相关残疾领导力教育（LEND）密切合作， 程序）。CTC提供集中的资源以及新颖的尖端技术， 推动将基因、大脑和行为联系起来的缺碘症研究。CTC是推进科学的一部分， 影响智力和/或发育障碍者的生活。 资格：服务提供给CHOP/Penn IDDRC的批准用户和跨站点协作 与IDDRC网络中的其他人。

(CORE B- CTC: CLINICAL TRANSLATIONAL CORE) PROJECT SUMMARY Description: The Clinical Translational Core (CTC) provides a comprehensive set of services designed to enhance the impact and rigor of clinical translational research on Intellectual and Developmental Disabilities (IDD). Select services are novel and unavailable outside of the CTC; other services increase research efficiency and enhance quality control over study activities common to all CT research. Freeing individual IDDRC users of the burden of common activities in turn allows users to better deploy resources for innovation and maximizing the impact of their translational science. CTC services fall into four areas: (1) Assistance with assembling suitably large study cohorts to support rigorous, well-powered research. Recruitment of large samples is necessary for studies of developmental disabilities which have diverse clinical manifestations that must be measured and controlled for in data analyses to garner reproducible results. (2) Creation of study specific interactive databases and visualization tools which allow labs to track their study progress, efficiently allocate resources and effort, and prepare study reports and data submissions (e.g., NIMH Data Archive). The CTC, in collaboration with the Genomics and Data Integration and Neuroimaging and Neurocircuitry cores, support integration of different data types. (3) Support all phases of IRB and IND protocol preparation, submission and response to stipulations; and provide concierge services for other freely available research supports already on campus, such as services offered by CHOP’s Clinical Trials office, and services provided by the Penn/CHOP Clinical and Translational Science Award (CTSA). (4) Expert clinical assessment support, including support with conventional psychological measurement; computable phenotypes from bioinformatic analyses of the electronic health records (EHR); and novel digital phenotyping using computer vision and computational linguistics to achieve granular measurement of speech, language and observable behaviors (e.g., nonverbal facial expressions and synchrony between individuals during interactions). These technologies and analytic capabilities are especially valued as they are not otherwise available on campus or commercially. The CTC will partner with the Preclinical Models Core on computer vision measurement of animal and human behaviors (e.g., gait), to derive features for mapping across species in order to more rapidly translate study findings and validate promising treatments. Relevance to IDDRC Mission: The CTC facilitates interdisciplinary translational research and training in IDDs (e.g., by working closely with the Leadership Education in Neurodevelopmental and Related Disabilities (LEND) program). The CTC provides centralized resources as well as novel cutting-edge techniques to support and advance IDD research linking genes, brain and behavior. The CTC is integral to advancing science that will impact the lives of those with an intellectual and/or developmental disability. Eligibility: Services are available to approved users of the CHOP/Penn IDDRC and for cross-site collaborations with others within the IDDRC network.