Effects of methamphetamine use on risk behavior, systemic and mucosal inflammation, and sexually transmitted infection (STI)/HIV risk among men who have sex with men

使用甲基苯丙胺对男男性行为者的危险行为、全身和粘膜炎症以及性传播感染 (STI)/HIV 风险的影响

• 批准号: 10450754
• 负责人: Cherie Savine Blair
• 金额: $ 20.24万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10450754
• 关键词: AIDS prevention; Acute; Adherence; Area; Attenuated; Behavior; Behavioral; Biological; Biological Markers; Biology; Chlamydia; Clinic; Clinical Trials; Communicable Diseases; Communities; Data; Development; Epidemic; Evidence based intervention; Frequencies; Funding; Future; Goals; Gonorrhea; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; HIV risk; Immune; Immunology; Impact evaluation; Impairment; Inflammation; Inflammatory; Intervention; Investigation; Joints; K-Series Research Career Programs; Link; Longitudinal Studies; Measures; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methamphetamine; Methamphetamine dependence; Methods; Modification; Mucositis; Mucous Membrane; National Institute of Drug Abuse; Participant; Pharmaceutical Preparations; Plasma; Prevention strategy; Reporting; Research; Research Personnel; Research Training; Rewards; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Sex Behavior; Sexual Partners; Sexually Transmitted Diseases; Specimen; Statistical Methods; Swab; Universities; Urine; Viral Load result; Visit; addiction; base; biobehavior; career; cohort; condomless anal sex; contingency management; cytokine; design; drug abstinence; effective intervention; efficacy testing; inflammatory marker; innovation; men who have sex with men; methamphetamine effect; methamphetamine exposure; methamphetamine use; multidisciplinary; multimodality; novel; operation; pre-exposure prophylaxis; preventive intervention; procedure safety; recruit; rectal; responsible research conduct; screening; sexual HIV transmission; sexual risk behavior; skills; statistics; substance use; systemic inflammatory response; tool; transmission process

PROJECT SUMMARY/ABSTRACT This K23 Career Development Award will provide early career support for the investigation of behavioral and biological risk factors for HIV/STI transmission caused by methamphetamine (MA) use among men who have sex with men (MSM). This K23 award will provide support for the candidate to develop expertise in the following areas: 1) Biological impacts of MA use and addiction medicine; 2) Clinical trials methods and biobehavioral interventions; 3) Applied immunology; 4) Professional development; and 5) Responsible conduct of research. Dr. Blair will be mentored by a multidisciplinary team with expertise in addiction, infectious diseases, immunology, and statistics. Dr. Steven Shoptaw has an extensive track record in addiction research and training of future independent investigators. Dr. Jesse Clark will provide mentorship in clinical trial methods, operations, and safety procedures; Dr. Grace Aldrovandi will provide mentorship in applied immunology, with an emphasis on mucosal immunology; and Dr. Robert Weiss will provide mentoring in advanced statistical methods. MA use is an important driver of HIV transmission and the burgeoning STI epidemic among MSM. Understanding the interaction of biological and behavioral risk factors for HIV/STI transmission caused by MA use is imperative for effective HIV/STI interventions. Dr. Blair proposes to investigate the joint effects of MA use, HIV, sexual risk behavior, and rectal gonorrhea/chlamydia (GC/CT) on systemic and rectal inflammation. Stored plasma specimens and behavioral data obtained every 6 months over 2 years from 140 MSM will be used to assess the joint effects of HIV and MA use on systemic inflammation and risk behavior using a 2x2 factorial design stratified by HIV serostatus (70 positive; 70 negative) and results of urine MA screening (70 with MA use; 70 without MA use). 40 HIV-negative MA-using MSM (20 with rectal GC/CT; 20 without rectal GC/CT) will be recruited separately from a community-based university research clinic. MA exposure will be manipulated using contingency management (CM) to evaluate the effects of a decline in MA use on biological markers of inflammation (e.g., cytokines). Following initiation of CM, sexual risk behaviors will be assessed weekly for 8 weeks. Inflammatory rectal cytokines will be measured weekly with rectal swabs and linked with biomarkers of MA exposure over 8 weeks. These activities will accomplish the following aims: 1) Measure the joint effects of HIV and MA use on systemic cytokine concentrations and risk behavior; 2) Identify the effects of MA exposure and concomitant rectal GC/CT on rectal cytokine concentrations; and 3) Evaluate the association of MA use frequency with sexual risk behavior in the setting of rectal inflammation. Through this K23 Career Development Award, Dr. Blair will establish herself as an independent clinician-investigator with expertise in intersectional research on the biological and behavioral impacts of MA and other drugs on HIV/STI transmission dynamics.

项目概要/摘要 K23 职业发展奖将为行为和行为调查提供早期职业支持 男性中因使用甲基苯丙胺 (MA) 导致 HIV/STI 传播的生物危险因素 与男性发生性行为（MSM）。该 K23 奖项将为候选人提供支持，以发展该领域的专业知识 以下领域： 1) MA 使用和成瘾药物的生物学影响； 2) 临床试验方法和 生物行为干预； 3）应用免疫学； 4）专业发展； 5) 负责任的行为 研究。布莱尔博士将接受多学科团队的指导，该团队在成瘾、传染病等方面拥有专业知识。 疾病、免疫学和统计学。 Steven Shoptaw 博士在成瘾研究方面拥有丰富的经验 以及对未来独立调查员的培训。 Jesse Clark 博士将提供临床试验指导 方法、操作和安全程序； Grace Aldrovandi 博士将提供应用指导 免疫学，重点是粘膜免疫学；罗伯特·韦斯博士将提供指导 先进的统计方法。 MA 的使用是 HIV 传播和 STI 迅速蔓延的重要驱动因素 MSM 中流行。了解艾滋病毒/性传播感染的生物学和行为风险因素的相互作用 有效干预艾滋病毒/性传播感染至关重要。布莱尔博士提议 调查 MA 使用、HIV、性危险行为和直肠淋病/衣原体 (GC/CT) 对健康的联合影响 全身和直肠炎症。储存的血浆样本和每 6 个月获得的行为数据 140 MSM 的 2 年将用于评估 HIV 和 MA 使用对全身炎症的联合影响 使用 2x2 因子设计按 HIV 血清状态（70 例阳性；70 例阴性）和结果进行分层的风险行为 尿液 MA 筛查（70 名使用 MA；70 名不使用 MA）。 40 名 HIV 阴性 MA 使用 MSM（20 名使用直肠 气相色谱/CT； 20 名没有直肠 GC/CT 的人）将从社区大学研究中单独招募 诊所。将使用应急管理 (CM) 来操纵 MA 暴露，以评估 MA 的影响 MA 对炎症生物标志物（例如细胞因子）的使用减少。 CM 开始后，性风险 行为将在 8 周内每周进行评估。每周测量直肠炎症细胞因子 直肠拭子并与 8 周内 MA 暴露的生物标志物相关联。这些活动将实现 以下目标：1) 测量 HIV 和 MA 使用对全身细胞因子浓度和风险的联合影响 行为; 2) 确定 MA 暴露和伴随直肠 GC/CT 对直肠细胞因子的影响 浓度； 3) 评估 MA 使用频率与性危险行为的关联 直肠炎症。通过这个 K23 职业发展奖，布莱尔博士将确立自己作为 独立临床医生研究员，具有生物学和行为学交叉研究的专业知识 MA 和其他药物对 HIV/STI 传播动态的影响。