Mentoring in patient-oriented research to finding a cure for HIV-1 infection
指导以患者为导向的研究,寻找 HIV-1 感染的治疗方法
基本信息
- 批准号:10450089
- 负责人:
- 金额:$ 19.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-13 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdherenceAdultAntigensAreaBasic ScienceBioinformaticsBiological AssayBirthBotswanaCellsCellular ImmunologyCharacteristicsChildhoodChromatinClinicClinicalClinical MedicineClinical ResearchClinical SciencesClinical TrialsClinical Trials DesignCollaborationsCommunicable DiseasesCommunitiesComplementComplexConduct Clinical TrialsConsensusCreativenessDevelopmentDiseaseDisease remissionDoctor of PhilosophyEducational workshopEpigenetic ProcessEvolutionFacultyFundingFutureGeneral HospitalsGeneticGenetic TranscriptionGenomeHIVHIV-1HomeHospitalsHourHumanImmune responseImmune systemImmunologicsIndividualInfantInfectionInstitutesInstitutionInterruptionInterventionIntervention StudiesInvestigationKnowledgeLaboratory ResearchLengthLifeLife ExpectancyMassachusettsMentorsMentorshipMolecularMolecular ImmunologyMonitorNational Institute of Allergy and Infectious DiseaseNeonatalPatientsPersonsPharmaceutical PreparationsPhysiciansPositioning AttributePredispositionPrincipal InvestigatorProceduresProteomicsResearchResearch ActivityResearch InfrastructureResearch PersonnelResearch Project GrantsResidual stateResourcesRetrovirologySamplingScientistSubgroupSystems BiologyTechniquesTechnologyTherapeutic InterventionTimeTrainingTraining ProgramsTranslatingTranslational ResearchUnited States National Institutes of HealthUniversitiesViralViral Load resultViral reservoirVirus DiseasesVirus IntegrationWomanWorkantiretroviral therapybridge programcareerchromatin immunoprecipitationclinical caredesignexperiencegenome analysisglobal healthimprovedinfant infectioninnovationintegration siteinterestmembermultidimensional dataneonatal infectionneonateneutralizing antibodynew technologynext generationnext generation sequencingnovelnovel therapeutic interventionpatient orientedpatient oriented researchpatient populationpediatric human immunodeficiency virusprogramsprotocol developmentresearch studyskillstherapy developmenttraining opportunity
项目摘要
Abstract
Dr. Lichterfeld is an infectious disease physician-scientist with a strong record of mentoring research fellows in
high-profile, patient-oriented research studies related to HIV-1 cure and eradication. He conducts a broad and
diverse research program of patient-oriented studies that include molecular and cellular immunologic studies
with patient-derived cells, translational human investigations and interventional clinical trials designed to explore
novel therapeutic approaches to reduce HIV-1 reservoirs. These research activities provide attractive and
exciting training opportunities for physicians and scientists interested and invested in developing strategies for a
functional or sterilizing cure for HIV-1 infection; in the past, several of his mentees and co-mentees have
progressed to receive R-level funding, and have been offered independent faculty positions at highly-selective
universities around the world. In the proposed K24 application, Dr. Lichterfeld will extend and expand his
successful mentoring activities in the context of three cutting-edge research areas: He will mentor trainees in the
conceptualization, design, implementation and conduct of interventional clinical trials designed to explore novel
therapeutic strategies for HIV-1 eradication (Specific Aim 1). These activities will initially focus on an already
ongoing, NIAID-funded clinical trial in which Dr. Lichterfeld serves as the PI, but will be expanded in the future
to translate novel ideas and concepts into exploratory, proof-of-concept clinical trials. These studies take
advantage of advanced clinical trial research infrastructure and a highly motivated HIV-1 patient population at
the Brigham and Women’s Hospital and the Massachusetts General Hospital, the two hospitals Dr. Lichterfeld
is affiliated with. In addition, Dr. Lichterfeld will train his mentees in innovative next-generation sequencing and
proteomics approaches involving single-genome, near full-length viral sequencing, combined with viral
integration site analysis, chromatin accessibility assays and chromatin immunoprecipitation assays to profile
residual viral reservoirs in patient-derived cell samples at an unprecedented breadth (Specific Aim 2). This work
will be facilitated by unique technical resources and cross-disciplinary collaborations at the Ragon Institute and
the Broad Institute of MIT and Harvard, where Dr. Lichterfeld holds Associate Member status. Finally, Dr.
Lichterfeld will offer a distinct training experience in pediatric HIV-1 infection, focusing on the development of
interventions that may enable a long-term, drug free remission of HIV-1 infection in neonates from Botswana
(Specific Aim 3). These collaborative investigations will be performed in the context of ongoing, NIAID-funded
clinical trials investigating effects of standard antiretroviral therapy and broadly-neutralizing antibodies on viral
reservoirs and antiviral immune responses in HIV-1-infected infants started on therapy within the first days after
birth. Together, these studies provide distinct but interrelated training opportunities for physicians and scientists
to acquire the knowledge, skills, creativity and collaborations that are needed for an independent career in
patient-oriented studies focused on finding a cure for HIV-1 infection.
摘要
项目成果
期刊论文数量(0)
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Mathias Lichterfeld其他文献
Mathias Lichterfeld的其他文献
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{{ truncateString('Mathias Lichterfeld', 18)}}的其他基金
Single-cell Proteogenomic profiling of HIV-1 reservoir cells
HIV-1 储存细胞的单细胞蛋白质组学分析
- 批准号:
10675812 - 财政年份:2023
- 资助金额:
$ 19.21万 - 项目类别:
High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Project 2
HIV 病毒库的持续性和扰动的高清表征:项目 2
- 批准号:
10469112 - 财政年份:2022
- 资助金额:
$ 19.21万 - 项目类别:
High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Project 2
HIV 病毒库的持续性和扰动的高清表征:项目 2
- 批准号:
10654776 - 财政年份:2022
- 资助金额:
$ 19.21万 - 项目类别:
Pioneering Precision Medicine Approaches for Immune Control of Pediatric HIV-1 Infection
儿科 HIV-1 感染免疫控制的开创性精准医学方法
- 批准号:
10696263 - 财政年份:2021
- 资助金额:
$ 19.21万 - 项目类别:
Pioneering Precision Medicine Approaches for Immune Control of Pediatric HIV-1 Infection
儿科 HIV-1 感染免疫控制的开创性精准医学方法
- 批准号:
10495251 - 财政年份:2021
- 资助金额:
$ 19.21万 - 项目类别:
Mentoring in patient-oriented research to finding a cure for HIV-1 infection
指导以患者为导向的研究,寻找 HIV-1 感染的治疗方法
- 批准号:
10669009 - 财政年份:2021
- 资助金额:
$ 19.21万 - 项目类别:
Pioneering Precision Medicine Approaches for Immune Control of Pediatric HIV-1 Infection
儿科 HIV-1 感染免疫控制的开创性精准医学方法
- 批准号:
10381148 - 财政年份:2021
- 资助金额:
$ 19.21万 - 项目类别:
Mentoring in patient-oriented research to finding a cure for HIV-1 infection
指导以患者为导向的研究,寻找 HIV-1 感染的治疗方法
- 批准号:
10258715 - 财政年份:2021
- 资助金额:
$ 19.21万 - 项目类别:
Novel single genome approaches to determine the mechanisms of HIV latent infection in blood, gut, and lymph nodes
确定血液、肠道和淋巴结中 HIV 潜伏感染机制的新单基因组方法
- 批准号:
10611415 - 财政年份:2019
- 资助金额:
$ 19.21万 - 项目类别:
Novel single genome approaches to determine the mechanisms of HIV latent infection in blood, gut, and lymph nodes
确定血液、肠道和淋巴结中 HIV 潜伏感染机制的新单基因组方法
- 批准号:
10396456 - 财政年份:2019
- 资助金额:
$ 19.21万 - 项目类别:
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