NVEADRC Administrative Core (AC)

NVEADRC管理核心(AC) 摘要 我们的内华达州探索性阿尔茨海默病研究中心(NVEADRC)是一项新颖而雄心勃勃的研究 致力于填补现有ADRC的空白，即收集和共享高质量的生物医学数据 以及来自农村地区的痴呆症患者的样本。就像所有新企业一样，NVEADRC 需要一个全力以赴的领导，从项目开始就指导和确定其活动的优先顺序。为了这个， 我们选择了具有ADRC经验的强有力的领导者来领导该项目。管理核心(AC) 是我们NVEADRC的驱动实体。它将监督一个强大的研究和教育活动 由克利夫兰临床卢鲁沃脑健康中心的研究人员组成的多学科团队 (LRBCH)和内华达大学拉斯维加斯分校(UNLV)。大多数调查人员已经是其他 协作项目，这将极大地促进不同核心之间的早期沟通，因为大多数 企业中的参与者已经意识到成功的大型协作项目的要求。我们有 为空中客车制定四个战略目标。在目标1中，AC将设置核心操作，目标是运行 几十年来的项目。为此，咨询委员会将每月召开会议，与所有核心领导人讨论进展情况 和挑战。会议纪要将发送给所有NVEADRC参与者，以收集改进反馈 以及对小说方向的建议。咨询委员会将确保成功整合参与的乡郊用地和 调查人员，并促进发展与和解中心网络内的合作。咨询委员会将协调审查工作，并 通过整合来自内部和外部咨询委员会的反馈，为NVEADRC提供指导。在……里面 目标2，咨询委员会将致力于农村痴呆症医疗保健和科学研究的专业化，通过确定 针对农村医务人员的具体需求，在神经退行性疾病教育中创设专门的 为内华达州及其他地区的大型广播提供课程和材料(如小册子和录像带)。此外，通过 促进女性教师的职业发展AC希望提供一种变革性的经验，以建立一个 未来ADRC的女性合作者和项目负责人的渠道。在目标3中，我们将利用我们的社区 让患者了解临床试验，并在我们的临床队列中招募农村受试者。在目标4中， 咨询委员会将制定必要的合规评估程序，并监测业绩。这包括 遵守人类主体、科学诚信、信息安全和财务政策要求 国家卫生研究院。此外，咨询委员会将制定核心评估程序，以根据预 确定的年度目标。非常重要的是，AC负责成功传输捕获的数据 从我们的农村受试者到国家阿尔茨海默氏症协调中心(NACC)。在它的坚强领导下，我们的 团队已经准备好应对这一人类挑战，以显著改善痴呆症研究和医疗保健 在内华达州。

NVEADRC ADMINISTRATIVE CORE (AC) SUMMARY Our Nevada Exploratory Alzheimer’s Disease Research Center (NVEADRC) is a novel and ambitious research endeavor aiming at filling a gap from existing ADRCs, which is to collect and share high-quality biomedical data and specimens from individuals suffering dementia from rural areas. Like for all novel enterprises, the NVEADRC needs a fully committed leadership to steer and prioritize its activities from the beginning of the project. For this, we have selected strong leaders with prior ADRC experience to lead the project. The Administrative Core (AC) is the driving entity for our NVEADRC. It will oversee the research and educational activities of a strong multidisciplinary team composed of investigators from the Cleveland Clinic Lou Ruvo Center for Brain Health (LRBCH) and University of Nevada, Las Vegas (UNLV). Most of the investigators are already part of other collaborative projects, which will greatly facilitate communication between the different Cores early on since most actors in the enterprise are already aware of the requirements for a successful large collaborative project. We have set four strategic aims for the AC. In Aim 1, the AC will set up Cores operations with the goal of running this project over several decades. For this, the AC will call monthly meetings with all Core leaders to address progress and challenges. The meeting minutes will be sent to all NVEADRC actors to collect feedback for improvement and suggestions on novel directions. The AC will assure the successful integration of participating rural sites and investigators, and promote collaborations within the ADRC network. The AC will coordinate the review and guidance of the NVEADRC by integrating the feedback from an internal and an external advisory committee. In Aim 2, the AC will work on professionalizing rural dementia healthcare and scientific research by determining the specific needs of rural medical professionals in neurodegenerative disorders education to create specific courses and materials (e.g. brochures and videos) for large broadcasting in NV and beyond. Moreover, by fostering the career development of female faculty the AC wants to offer a transformative experience to build a pipeline of future female ADRC collaborators and project leaders. In Aim 3, we will leverage our community connections to inform patients about clinical trials and to recruit rural subjects in our clinical cohort. In Aim 4, the AC will develop the necessary assessment procedures for compliance and to monitor performance. This includes compliance with human subjects, scientific integrity, information security and financial policy requirements from NIH. In addition, the AC will create the procedures for Core assessments to gauge progress based on pre- determined annual goals. Very importantly, the AC is in charge of the successful transfer of the data captured from our rural subjects to the National Alzheimer’s Coordinating Center (NACC). Under its strong leadership, our team is ready to tackle this human challenge in order to dramatically improve dementia research and healthcare in the State of Nevada.