Infant Bronchiolitis and Viral Core (IBVC)

项目总结/摘要 呼吸道合胞病毒（RSV）在儿童中引起一系列疾病， 感染到严重的下呼吸道疾病，如细支气管炎和肺炎。虽然 从上呼吸道到下呼吸道疾病进展的决定因素，毛细支气管炎的严重程度， 复发性和长期发病率，如反复喘息或哮喘，尚未完全了解， 宿主特异性和病毒特异性因素似乎有助于这种感染的发病机理和/或结果。 我们P01的长期目标是了解粘膜在病毒和过敏原诱导的气道中的作用。 炎症和重塑。我们将通过提供新的机制来推进我们的目标和领域， 先天性病毒和过敏原刺激产生表观遗传重塑，氧化损伤和重编程的 先天性粘膜干扰素（IFN）反应。婴儿毛细支气管炎和病毒核心（IBVC）的目的是 从一群感染了以下疾病的幼儿中获得高质量的临床注释粘膜样本： 呼吸道合胞病毒（RSV），并提供一个集中的科学资源，支持需要 优化的、均质的（高度可重复的）RSV制备物、免疫测定性能和使用 最先进的实验小鼠感染模型，这是研究项目（RP）RP 1-RP 3所需的 我们的P01有效管理和分发样品和数据将确保项目的成功。 此外，IBVC还将为P01中心提供服务、技术和智力支持 调查人员在一个功能，成本效益高，多用户的环境，这将提高生产力， 个人和合作研究计划。除了最先进的设备和方法， IBVC的工作人员提供科学和技术专业知识，使中心的研究人员在以下方面受益匪浅： 实验设计，执行和解释的条款，以及，通过提供一个合作的重点， 交互.

PROJECT SUMMARY/ABSTRACT Respiratory syncytial virus (RSV) causes a spectrum of disease in children ranging from upper respiratory infections to severe lower respiratory tract disease, such as bronchiolitis and pneumonia. Although the determinants of disease progression from the upper to the lower respiratory tract, severity of bronchiolitis, recurrences, and long-term morbidity, such as recurrent wheezing or asthma, are not fully understood, both host- and virus-specific factors appear to contribute to the pathogenesis and/or the outcome of this infection. The long-term goal of our P01 is to understand the role the mucosa plays in virus- and allergen-induced airway inflammation and remodeling. We will advance our aims and the field by providing new mechanisms by which innate viral and allergen stimuli produce epigenetic remodeling, oxidative injury and reprogramming of the innate mucosal interferon (IFN) response. The purpose of the Infant Bronchiolitis and Viral Core (IBVC) is to acquire high-quality, clinically annotated mucosal samples from a cohort of young children infected with respiratory syncytial virus (RSV), and to provide a centralized scientific resource that supports the need for optimized, homogeneous (highly reproducible) RSV preparations, immunoassay performance, and use of state-of-the art experimental mouse models of infection, which are required in research project (RP) RP1-RP3 of our P01. Efficient management and distribution of samples and data will ensure the success of the projects. Furthermore, the IBVC will provide services, technical and intellectual assistance to the P01 Center investigators in a functional, cost-efficient, and multi-user environment that will enhance the productivity of both individual and collaborative research programs. In addition to state-of-the-art equipment and methods, the key personnel of the IBVC provide scientific and technical expertise that greatly benefits the Center investigators in terms of experimental design, execution and interpretation, as well as, by providing a focus for collaborative interactions.