NORTHWESTERN UNIVERSITY PLUS CLINICAL SITE

项目摘要 下尿路症状（LUTS）在女性中很常见，并对日常生活活动产生负面影响 生活质量下降，导致医疗和心理疾病和巨大的经济负担。因为 关于LUTS对女性的有害后果，了解最佳膀胱健康至关重要。给定 女性泌尿系统症状的复杂性和异质性，需要进行跨学科研究， 筛查膀胱症状发展的危险因素，促进优化的保护因素 膀胱健康，以及预防计划的目标机制，以破坏膀胱疾病的因果途径， 迄今为止，关于LUTS的文献大多集中在健康的非西班牙裔白色女性。 有症状并已经参与医疗保健系统的人。因此，现存 预防和治疗方法不能普遍适用于少数群体等弱势群体， 服务不足的女性在了解少数民族和服务不足的膀胱健康方面仍然存在重大差距 妇女，在那里存在着巨大的健康差距。设计良好的泌尿系统疾病纵向队列研究 在少数种族/族裔有充分代表性的各种样本中，症状严重缺乏。 与PLUS研究联盟一致，我们的目标是超越没有症状， 优化膀胱健康作为“一个完整的状态的身体，心理和社会福祉有关的膀胱 功能”。因此，本项目的主要目标是评估生物学、心理学和社会学的影响。 (mind/行为）、人际、制度、环境和社会因素对膀胱健康的影响。 在PLUS框架内采用定性和定量方法，为不同的妇女提供服务。混合- 该项目的方法包括：具体目标1。进行纵向观察性研究， 膀胱健康在不同队列的青少年和成年妇女的种族/民族，年龄，收入， 教育、健康素养、保险状况、性取向和就业，具体目标2。确定 影响不同女性膀胱健康的因素和行为，以及具体目标3。创建筛选 膀胱健康的工具，是可靠和有效的不同妇女。我们假设社交 健康的决定因素、内隐偏见和歧视将与 膀胱健康和参与医疗保健系统随着时间的推移，LUTS。我们还假设， 我们开发的筛选器将评估所有女性的膀胱健康（包括其中 存在差异），并将以高可靠性，有效性， 准确性、灵敏度和特异性，以及对应答者的最小负担。U 01的影响将是 管理关于不同妇女群体的风险和保护因素的新知识库。

Project Summary Lower urinary tract symptoms (LUTS) are common in women and negatively impact activities of daily living and quality of life, resulting in medical and psychological morbidity and enormous economic burden. Because of the deleterious consequences of LUTS on women, understanding optimal bladder health is essential. Given the complexity and heterogeneity of women with urinary symptoms, transdisciplinary research is needed to screen for risk factors for the development of bladder symptoms, protective factors that facilitate optimized bladder health, and mechanisms to target for prevention programs to disrupt causal pathways to bladder symptoms To date, the literature on LUTS has mostly focused on non-Hispanic White women with health insurance who present with symptoms and are already engaged with the healthcare system. Thus, extant prevention and treatment approaches are not generalizable to vulnerable populations like minority and underserved women. Significant gaps remain in understanding bladder health for minority and underserved women, where significant health disparities exist. Well-designed longitudinal cohort studies of urinary symptoms in diverse samples in which racial/ethnic minorities are well represented are severely lacking. Consistent with the PLUS Research Consortium, our objective is to move beyond the absence of symptoms and optimize bladder health as “a complete state of physical, mental, and social well-being related to bladder function.” Therefore, the primary goal of this project is to assess the influence of biological, psychosocial (mind/behavior), interpersonal, institutional, environmental, and societal factors on bladder health among diverse women using qualitative and quantitative approaches within the PLUS framework. The mixed- methods approach of this project includes: Specific Aim 1. Conduct a longitudinal, observational study of bladder health in a diverse cohort of adolescent and adult women with respect to race/ethnicity, age, income, education, health literacy, insurance status, sexual orientation, and employment, Specific Aim 2. Determine factors and behaviors that influence bladder health in diverse women, and Specific Aim 3. Create a screening tool for bladder health that is reliable and valid across diverse women. We hypothesize that social determinants of health, implicit bias, and discrimination will be significantly related to the trajectory of bladder health and engagement with the healthcare system over time for LUTS. We also hypothesize that the screener we develop will assess bladder health in all women (including diverse populations in which disparities exist) and will identify women at risk for future bladder symptoms with high reliability, validity, accuracy, sensitivity, and specificity and minimal burden to the respondent. The impact of this U01 will be the curation of a novel knowledge base on risk and protective factors in diverse populations of women.