NORTHWESTERN UNIVERSITY PLUS CLINICAL SITE

西北大学加临床站点

• 批准号: 10248550
• 负责人: James William Griffith
• 金额: $ 40万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10248550
• 关键词: Activities of Daily Living; Adolescent; Adult; Affect; Assessment tool; Behavior; Biological; Biology; Bladder; Clinical; Clinical Research; Cohort Studies; Communities; Data; Development; Discrimination; Economic Burden; Education; Employment; Enrollment; Environmental Risk Factor; Epidemiology; Ethnic Origin; Evaluation; Foundations; Future; Goals; Gynecologist; Health; Health Insurance; Healthcare Systems; Heterogeneity; Income; Insurance Coverage; Interview; Leadership; Letters; Literature; Longevity; Longitudinal cohort study; Longitudinal observational study; Measurement; Measures; Medical; Medical center; Methodology; Methods; Mind; Minority; Minority Groups; Morbidity - disease rate; Not Hispanic or Latino; Outcome; Participant; Pathway interactions; Plant Roots; Population; Population Heterogeneity; Predictive Factor; Prevention; Prevention program; Prevention trial; Psyche structure; Psychologist; Quality of life; Race; Research; Research Personnel; Respondent; Risk; Risk Factors; Sampling; Screening procedure; Sensitivity and Specificity; Sex Orientation; Site; Social Well-Being; Societal Factors; Symptoms; Time; Translating; United States National Institutes of Health; Universities; Vulnerable Populations; Woman; Women' s Health; Work; Workplace; behavior influence; clinical research site; cohort; common symptom; community engaged research; community engagement; community organizations; community partnership; demographics; epidemiology study; ethnic minority population; experience; health disparity; health literacy; implementation science; implementation study; implicit bias; improved; knowledge base; longitudinal design; lower urinary tract symptoms; minority health; multidisciplinary; novel; physical state; prevent; programs; prospective; protective factors; psychologic; psychosocial; racial and ethnic; recruit; response; screening; social; social health determinants; success; urinary

Project Summary Lower urinary tract symptoms (LUTS) are common in women and negatively impact activities of daily living and quality of life, resulting in medical and psychological morbidity and enormous economic burden. Because of the deleterious consequences of LUTS on women, understanding optimal bladder health is essential. Given the complexity and heterogeneity of women with urinary symptoms, transdisciplinary research is needed to screen for risk factors for the development of bladder symptoms, protective factors that facilitate optimized bladder health, and mechanisms to target for prevention programs to disrupt causal pathways to bladder symptoms To date, the literature on LUTS has mostly focused on non-Hispanic White women with health insurance who present with symptoms and are already engaged with the healthcare system. Thus, extant prevention and treatment approaches are not generalizable to vulnerable populations like minority and underserved women. Significant gaps remain in understanding bladder health for minority and underserved women, where significant health disparities exist. Well-designed longitudinal cohort studies of urinary symptoms in diverse samples in which racial/ethnic minorities are well represented are severely lacking. Consistent with the PLUS Research Consortium, our objective is to move beyond the absence of symptoms and optimize bladder health as “a complete state of physical, mental, and social well-being related to bladder function.” Therefore, the primary goal of this project is to assess the influence of biological, psychosocial (mind/behavior), interpersonal, institutional, environmental, and societal factors on bladder health among diverse women using qualitative and quantitative approaches within the PLUS framework. The mixed- methods approach of this project includes: Specific Aim 1. Conduct a longitudinal, observational study of bladder health in a diverse cohort of adolescent and adult women with respect to race/ethnicity, age, income, education, health literacy, insurance status, sexual orientation, and employment, Specific Aim 2. Determine factors and behaviors that influence bladder health in diverse women, and Specific Aim 3. Create a screening tool for bladder health that is reliable and valid across diverse women. We hypothesize that social determinants of health, implicit bias, and discrimination will be significantly related to the trajectory of bladder health and engagement with the healthcare system over time for LUTS. We also hypothesize that the screener we develop will assess bladder health in all women (including diverse populations in which disparities exist) and will identify women at risk for future bladder symptoms with high reliability, validity, accuracy, sensitivity, and specificity and minimal burden to the respondent. The impact of this U01 will be the curation of a novel knowledge base on risk and protective factors in diverse populations of women.

项目摘要 较低的尿路症状（LUTS）在女性中很常见，并对日常生活产生负面影响 和生活质量，导致医学和心理发病率和巨大的经济负担。因为 在LUTS对妇女的删除后果中，了解最佳膀胱健康至关重要。给出 具有尿符号的女性的复杂性和异质性，需要跨学科研究才能 屏幕屏蔽膀胱符号开发的风险因素，这是促进优化的受保护因素 膀胱健康和针对预防计划的机制破坏了因果途径到膀胱 迄今为止的症状，有关LUTS的文献主要集中于健康的白人妇女 出现症状并已经与医疗保健系统互动的保险。那是广泛的 预防和治疗方法无法推广到少数族裔和 服务不足的妇女。在理解少数群体和服务不足的膀胱健康方面仍然存在很大的差距 妇女，存在很大的健康差异。精心设计的尿液纵向队列研究 种族/族裔少数族裔的症状严重缺乏。 与加大研究联盟一致，我们的目标是超越没有症状和 优化Bladeder Health作为“与Bladeder相关的身体，心理和社会福祉的完整状态 因此，该项目的主要目标是评估生物学，社会心理的影响 （思维/行为），人际关系，机构，环境和社会因素，膀胱健康 在加号框架内使用定性和定量方法的多样化妇女。混合 该项目的方法方法包括：特定目标1。进行纵向，观察性研究 关于种族/种族，年龄，收入， 教育，健康素养，保险状况，性取向和就业，具体目标2。 影响潜水妇女膀胱健康的因素和行为，以及特定的目标3。 膀胱健康的工具可靠，在潜水员中有效。我们假设社会 健康，隐性偏见和歧视的决定因素将与 随着时间的流逝，膀胱健康和与医疗保健系统的参与。我们还假设 我们开发的筛选器将评估所有女性的膀胱健康（包括潜水员人群 存在差异），并将确定具有高可靠性，有效性， 对受访者的准确性，敏感性和特异性以及最小的燃烧。该U01的影响将是 新知识基础的策划在女性潜水员人群中的风险和受保护因素的策划。