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Common and Specific Neural Mechanisms of Perseverative Thought in Real-World Contexts

现实世界中持久思维的常见和特定神经机制

基本信息

批准号：
10454828
负责人：
LAUREN S HALLION
金额：
$ 17.52万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10454828
关键词：
Adult Amygdaloid structure Anterior Anxiety Anxiety Disorders Attention Behavioral Clinical Data Data Analytics Depressive disorder Development Dimensions Dorsal Ecological momentary assessment Emotional Emotions Environment Equation Eye Functional Magnetic Resonance Imaging Functional disorder Generalized Anxiety Disorder Goals Impairment Instruction Insula of Reil Intervention Life Link Literature Major Depressive Disorder Measures Mental Depression Mental disorders Mentorship Modeling Moods National Institute of Mental Health Neurobiology Neurocognitive Operative Surgical Procedures Participant Pathologic Patient Self-Report Pattern Population Prevention Protocols documentation Psychopathology Public Health Recovery Regulation Relapse Research Sampling Series Services Severities Structure Substance abuse problem Task Performances Testing Thinking Time Training Work anxiety-related disorders career cingulate cortex cognitive control experience experimental study follow-up immune function indexing neural model neuroimaging neuromechanism physical conditioning prospective psychologic public health relevance relating to nervous system rumination skills stress reactivity success sustained attention theories therapy development two-dimensional virtual

项目摘要

Anxiety and depressive disorders are the most prevalent forms of mental illness and are a major public health concern. There is growing evidence that perseverative thought (PT), defined as thought that is self-focused, repetitive, and difficult-to-control, is a key mechanism of anxiety and depression. Worry and rumination are two prevalent and well-characterized forms of PT that have been experimentally and prospectively linked to increased anxiety and depression severity, higher rates of substance abuse, and poorer physical health. However, little is known about the underlying neurobiology of PT, and no studies to date have characterized the neural mechanisms that underlie the successful or unsuccessful regulation of PT. This gap in the literature is of central importance because an impaired ability to disengage from PT (i.e., an ability to stop worrying and ruminating) has been proposed as a central mechanism by which worry or rumination transitions from normative to pathological. The overarching goal of this K01 is to develop and test an ecologically-valid, clinically-informed neurobiological model of PT, with a particular emphasis on identifying the mechanisms by which PT shifts from healthy to pathological through successful and unsuccessful regulation. Using functional magnetic resonance imaging (fMRI) and ecological momentary assessment (EMA), the proposed study will 1) test specific neurobiological hypotheses about the mechanisms underlying successful and failed disengagement from PT; 2) evaluate the neurobiological plausibility of three competing clinically-derived models of PT (i.e., a bifactor vs. two-factor vs. dimensional model); and 3) link neurobiological findings to real- world experiences of pathological (dysregulated) worry and rumination. Collectively, these aims will permit the iterative refinement of a clinically meaningful neurobiological model of normative and pathological PT, which can form the basis for the development of neurobiologically informed interventions. Consistent with a transdiagnostic approach informed by the Research Domains Criteria (RDoC), N = 70 adults who represent the full spectrum of PT severity (low; moderate; pathological) will undergo fMRI while experiencing and then attempting to disengage from PT (worry and rumination). Disengagement success will be assessed via thought sampling. A subset of participants with pathological PT will then complete an EMA protocol to index real-world experiences of successful and failed disengagement from PT. A variety of data analytic approaches, including functional and effective connectivity, mixed models, and structural equation modeling will be applied to test specific hypotheses and in follow-up exploratory analyses. The training plan capitalizes on the candidate's background, mentorship team, research environment to provide the candidate with the requisite neuroimaging, EMA, and data analytic skills to conduct the proposed research and launch a successful independent research career aimed at identifying the neurocognitive mechanisms of emotion-related psychopathology (NIMH Strategic Objective 1) in service of identifying new targets for treatment (NIMH Strategic Objective 3).

焦虑和抑郁障碍是最普遍的精神疾病形式，是一个主要的公共卫生问题

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Worry alters speed-accuracy tradeoffs but does not impair sustained attention.

DOI：
10.1016/j.brat.2020.103597
发表时间：
2020-05
期刊：
Behaviour research and therapy
影响因子：
4.1
作者：
Hallion LS;Kusmierski SN;Caulfield MK
通讯作者：
Caulfield MK

A five-factor model of perseverative thought.

DOI：
10.1037/abn0000737
发表时间：
2022-04
期刊：
JOURNAL OF PSYCHOPATHOLOGY AND CLINICAL SCIENCE
影响因子：
0
作者：
Hallion, Lauren S;Wright, Aidan G C;Joormann, Jutta;Kusmierski, Susan N;Coutanche, Marc N;Caulfield, M Kathleen
通讯作者：
Caulfield, M Kathleen

Impaired disengagement from worry: Dissociating the impacts of valence and internally-directed attention.

摆脱忧虑的能力受损：将效价和内部注意力的影响区分开来。