Bladder health promotion and LUTS prevention inadolescent and adult women across the life course
在青春期和成年女性的整个生命过程中促进膀胱健康并预防 LUTS
基本信息
- 批准号:10455020
- 负责人:
- 金额:$ 10万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-08-15 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescentAdultAffectBehaviorBehavioralBiologicalBladderChronicClinical ResearchCohort AnalysisCohort StudiesCommunitiesComplementCross-Sectional StudiesDataDeteriorationDevelopmentDiagnosisEcologyEducational InterventionEducational ModelsEpidemiologyEvaluationFemaleFocus GroupsFoundationsFutureGoalsHealthHealth PromotionHigh PrevalenceIndividualInterventionIntervention StudiesInvestigationKnowledgeLife Cycle StagesMaintenanceMeasuresMeta-AnalysisMethodsNaturePainPatient Self-ReportPersonsPhasePopulationPreventionPublic HealthPublishingQuality of lifeResearchRiskRisk FactorsSeriesSiteTimeUniversitiesUrinary IncontinenceWashingtonWomanWorkcostdesignepidemiologic dataevidence baseexperimental studyfollow-upimplementation studyincontinence symptominnovationinsightintervention deliveryintervention mappinglower urinary tract symptomsmedical schoolsmemberpersistent symptompopulation basedpreferencepreventive interventionprospectiveprotective factorssocialsystematic reviewtool
项目摘要
ABSTRACT
Lower urinary tract symptoms (LUTS), including storage, voiding, urinary incontinence symptoms and pain,
and their associated diagnoses are common, costly, and negatively impact women's quality of life throughout
the life course. Despite their common occurrence and high cost, little research to date has focused on
identification of risk and protective factors for LUTS and prevention, and even less has focused on promotion
and maintenance of bladder health. To address this gap, the Prevention of Lower Urinary Tract Symptoms
(PLUS) Research Consortium (of which our site is a founding Clinical Research Center) was established to
develop the scientific foundation for future evidence-based bladder health promotion and LUTS prevention
interventions in adolescent and adult women. In this application, we propose to build upon foundational work
conducted in PLUS 1 to further this scientific foundation. Specifically, we propose to establish a large,
longitudinal, national, population-based, observational cohort study (currently under development and co-led
by the Washington University School of Medicine site PI) designed to: a) determine the distribution of and
changes in bladder health over time in the general female population; and b) identify new risk and protective
factors for LUTS and bladder health amenable to intervention. Per the FOA, we have selected one important
risk/protective factor research question for incorporation into the population-based cohort study: does chronic
delayed voiding, a common behavior among women across the life course that can be addressed by
preventive interventions at multiple levels of social ecology, contribute to bladder health deterioration
and the development of LUTS? Guided by an intervention mapping approach and community partner insight,
we will build the evidence base for this research question by conducting a series of innovative, multi-method,
transdiciplinary studies nested within the population-based cohort study, as well as complementary to this
study. Together, this comprehensive set of quantitative and qualitative studies will provide: 1) critical new data
to address the causal nature of associations between chronic delayed voiding and bladder health/LUTS (i.e.,
high-quality, prospective epidemiologic data devoid of temporal biases and supportive biologic, mechanistic
data); 2) new findings to inform the optimal focus and mode of delivery of future prevention interventions (i.e.,
multi-method data on the strongest individual-behavioral, interpersonal, institutional, and community/societal
determinants of chronic delayed voiding, the most effective mode of delivery of educational interventions
[assuming that future interventions will include an educational component], and initial promising educational
messages); and 3) new tools to evaluate future interventions. As such, this complementary set of studies
holds the promise to greatly expand the foundation of knowledge for future bladder health promotion
and LUTS prevention interventions.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Siobhan Sutcliffe其他文献
Siobhan Sutcliffe的其他文献
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{{ truncateString('Siobhan Sutcliffe', 18)}}的其他基金
Food-specific antibodies and urologic chronic pelvic pain syndrome.
食物特异性抗体和泌尿系统慢性盆腔疼痛综合征。
- 批准号:
10700928 - 财政年份:2022
- 资助金额:
$ 10万 - 项目类别:
Food-specific antibodies and urologic chronic pelvic pain syndrome.
食物特异性抗体和泌尿系统慢性盆腔疼痛综合征。
- 批准号:
10452193 - 财政年份:2022
- 资助金额:
$ 10万 - 项目类别:
Bladder health promotion and LUTS prevention inadolescent and adult women across the life course
在青春期和成年女性的整个生命过程中促进膀胱健康并预防 LUTS
- 批准号:
10663092 - 财政年份:2015
- 资助金额:
$ 10万 - 项目类别:
LUTS PREVENTION IN ADOLESCENT GIRLS AND WOMEN ACROSS THE LIFESPAN
青春期女孩和妇女一生中性欲的预防
- 批准号:
9762915 - 财政年份:2015
- 资助金额:
$ 10万 - 项目类别:
Bladder health promotion and LUTS prevention inadolescent and adult women across the life course
在青春期和成年女性的整个生命过程中促进膀胱健康并预防 LUTS
- 批准号:
10248533 - 财政年份:2015
- 资助金额:
$ 10万 - 项目类别:
Bladder health promotion and LUTS prevention inadolescent and adult women across the life course
在青春期和成年女性的整个生命过程中促进膀胱健康并预防 LUTS
- 批准号:
10908000 - 财政年份:2015
- 资助金额:
$ 10万 - 项目类别:
TRICHOMONOSIS AND PROSTATE CANCER RISK IN THE PLCO CANCER SCREENING TRIAL
PLCO 癌症筛查试验中的滴虫病和前列腺癌风险
- 批准号:
8049516 - 财政年份:2011
- 资助金额:
$ 10万 - 项目类别:
ENERGY BALANCE AND RISK OF BPH-RELATED OUTCOMES AND LUTS: A PROSPECTIVE STUDY
能量平衡以及 BPH 相关结果和 LUTS 的风险:一项前瞻性研究
- 批准号:
8326614 - 财政年份:2011
- 资助金额:
$ 10万 - 项目类别:
TRICHOMONOSIS AND PROSTATE CANCER RISK IN THE PLCO CANCER SCREENING TRIAL
PLCO 癌症筛查试验中的滴虫病和前列腺癌风险
- 批准号:
8214495 - 财政年份:2011
- 资助金额:
$ 10万 - 项目类别:
ENERGY BALANCE AND RISK OF BPH-RELATED OUTCOMES AND LUTS: A PROSPECTIVE STUDY
能量平衡以及 BPH 相关结果和 LUTS 的风险:一项前瞻性研究
- 批准号:
8189741 - 财政年份:2011
- 资助金额:
$ 10万 - 项目类别:
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