Characterization of intracranial vessel wall morphology and inflammation using 3D high resolution MRI

使用 3D 高分辨率 MRI 表征颅内血管壁形态和炎症

• 批准号: 10457439
• 负责人: Chengcheng Zhu
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-20 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10457439
• 关键词: 3-Dimensional; Aneurysm; Angiography; Anti-Inflammatory Agents; Arterial Fatty Streak; Asian; Blood; Blood Vessels; Brain; Cerebrospinal Fluid; Cerebrovascular Disorders; Cerebrovascular system; Clinical; Computer software; Contrast Media; Country; Descriptor; Detection; Disease; Europe; Evaluation; Functional disorder; Gadolinium; Goals; Gold; Hemorrhage; Histology; Image; Imaging technology; Incidence; Inflammation; Inflammatory; Intervention; Intracranial Aneurysm; Location; Magnetic Resonance Imaging; Measurement; Medical; Methods; Mission; Morphology; National Heart, Lung, and Blood Institute; Noise; Operative Surgical Procedures; Pathology; Patient observation; Patient risk; Patients; Performance; Pharmaceutical Preparations; Population; Predisposition; Prevalence; Protocols documentation; Reporting; Research; Resolution; Rupture; Sampling; Scanning; Schedule; Signal Transduction; Source; Specimen; Staging; Stroke; Techniques; Technology; Thick; Thrombus; Time; Training; Validation; Vendor; brain parenchyma; clinical application; clinical decision-making; design; detection method; effective therapy; ferumoxtran; healthy volunteer; high resolution imaging; high risk; imaging modality; improved; in vitro Model; in vivo; individualized medicine; macrophage; non-invasive imaging; novel strategies; prevent; reconstruction; response; simulation; stroke outcome; stroke risk; tool; treatment response; uptake

Project Summary Cerebrovascular disease is a major source of stroke. However, clinicians treating patients with intracranial vascular disease are often in a quandary as to the most effective treatment as the underlying pathophysiology and likely progression is obscure. Until recently, non-invasive evaluation of the source of pathology - the vessel wall - was not possible. Although advances in Magnetic Resonance Imaging (MRI) technology show potential for vessel wall imaging (VWI), the true performance metrics of these approaches are poorly defined. The true resolution and the characterization of wall components, specifically inflammatory components, have not been established and vary among practitioners. This project will implement new approaches to in vivo intracranial VWI using high field strength MRI (at 3T and 7T). This goal will be achieved with theoretical design and simulations, in vitro models, in vivo implementation, with histology validation. First: we will optimize high-resolution (sub 0.5mm isotropic) 3D black blood fast-spin-echo MRI (termed SPACE on Siemens platforms) at 3T and 7T for whole brain intracranial VWI. The vessel wall signal to noise ratio, sharpness, and contrast to surrounding cerebrospinal fluid (CSF) or brain parenchyma will be simulated and optimized. This will be validated on in vitro models and with in vivo scanning of 10 healthy volunteers and 10 patients with intracranial vascular disease. We will also implement compressed sensing method to reduce the scan time of the long acquisition (currently around 10 minutes) to make it clinically feasible. Second: 3D SPACE, Ultra-short echo time (UTE) sequences and T2* mapping/quantitative susceptibility mapping (QSM) methods for detecting inflammation using Ultra-Small Super-Paramagnetic Iron Oxide (USPIO) contrast agents will be developed and validated in USPIO phantoms with a range of concentrations. These methods will be optimized to detect USPIO uptake in 10 patients with intracranial plaques, and the best approaches will be determined. Confirmation of the location of uptake assessed on imaging performed immediately prior to scheduled surgery will be sought on histology in 10 patients with intracranial aneurysms. Third: The ability of 3T imaging to characterize high-risk vessel wall features (such as intraplaque hemorrhage, intra-luminal thrombus, gadolinium enhancement, and USPIO uptake) will be assessed compared to scanning at 7T on 30 patients with cerebrovascular disease. Successful project conduct will provide methods to characterize the high-risk features of the intracranial vessel wall that could be clinically used to evaluate risk of stroke on a patient-specific basis and with a tool for validation across vendor platforms. These methods could be used to guide patient-specific therapy and improve stroke outcome – directly supporting the mission of the National Heart, Lung, and Blood Institute.

项目概要 脑血管疾病是中风的主要病因。然而，临床医生在治疗颅内肿瘤患者时 血管疾病常常因潜在的病理生理学而陷入最有效治疗的困境 并且可能的进展是模糊的。直到最近，对病理来源——血管的非侵入性评估 墙 - 是不可能的。尽管磁共振成像 (MRI) 技术的进步显示出潜力 对于血管壁成像（VWI），这些方法的真实性能指标尚不清楚。真实的 壁成分（特别是炎症成分）的分辨率和表征尚未得到证实 已建立并在从业者之间有所不同。该项目将实施体内颅内研究的新方法 使用高场强 MRI（3T 和 7T）的 VWI。这一目标将通过理论设计和 模拟、体外模型、体内实施以及组织学验证。 首先：我们将优化高分辨率（亚 0.5mm 各向同性）3D 黑血快速自旋回波 MRI（称为 SPACE） 在西门子平台上）在 3T 和 7T 下进行全脑颅内 VWI。血管壁信噪比， 将模拟周围脑脊液 (CSF) 或脑实质的清晰度和对比度， 优化。这将在体外模型和 10 名健康志愿者和 10 名志愿者的体内扫描中得到验证。 患有颅内血管疾病的患者。我们还将实施压缩感知方法来减少 扫描时间长的采集（目前约为10分钟）使其在临床上可行。第二：3D空间， 超短回波时间 (UTE) 序列和 T2* 映射/定量磁化率映射 (QSM) 方法 使用超小超顺磁性氧化铁 (USPIO) 造影剂检测炎症将 在 USPIO 模型中以一系列浓度进行开发和验证。这些方法将被优化 检测 10 名颅内斑块患者的 USPIO 摄取情况，并确定最佳方法。 通过在预定手术前立即进行的成像评估来确认摄取位置 将对 10 名颅内动脉瘤患者进行组织学检查。第三：3T成像能力 描述高风险血管壁特征（例如斑块内出血、管腔内血栓、钆 增强和 USPIO 摄取）将与 7T 扫描相比对 30 名患者进行评估 脑血管疾病。 成功的项目实施将提供表征颅内血管高风险特征的方法 墙可在临床上用于根据患者具体情况评估中风风险，并提供工具 跨供应商平台的验证。这些方法可用于指导患者的特异性治疗并改善 中风结果——直接支持国家心肺血液研究所的使命。

项目成果

Quantitative analysis of unruptured intracranial aneurysm wall thickness and enhancement using 7T high resolution, black blood magnetic resonance imaging.

使用7T高分辨率黑血磁共振成像定量分析未破裂颅内动脉瘤壁厚度和增强情况

• DOI: 10.1136/neurintsurg-2021-017688
• 发表时间: 2022-07
• 期刊: Journal of neurointerventional surgery
• 影响因子: 4.8

Thrombectomy as a Safe and Feasible Option for the Treatment of Isolated Anterior Cerebral Artery Occlusion Stroke.

血栓切除术是治疗孤立性大脑前动脉闭塞性中风的安全可行的选择。

• DOI: 10.1148/radiol.230031
• 发表时间: 2023
• 期刊: Radiology
• 影响因子: 19.7
• 作者: Zhu,Chengcheng;Wang,Yuting
• 通讯作者: Wang,Yuting

Assessment of Therapeutic Response to Statin Therapy in Patients With Intracranial or Extracranial Carotid Atherosclerosis by Vessel Wall MRI: A Systematic Review and Updated Meta-Analysis.

• DOI: 10.3389/fcvm.2021.742935
• 发表时间: 2021
• 期刊: Frontiers in cardiovascular medicine
• 影响因子: 3.6
• 作者: Zhou P;Wang Y;Sun J;Yu Y;Mossa-Basha M;Zhu C
• 通讯作者: Zhu C

Clinical Significance of Intraplaque Hemorrhage in Low- and High-Grade Basilar Artery Stenosis on High-Resolution MRI.

高分辨率 MRI 低度和高度基底动脉狭窄斑块内出血的临床意义

• DOI: 10.3174/ajnr.a5676
• 发表时间: 2018-07
• 期刊: AJNR. American journal of neuroradiology
• 作者: Zhu C;Tian X;Degnan AJ;Shi Z;Zhang X;Chen L;Teng Z;Saloner D;Lu J;Liu Q
• 通讯作者: Liu Q

Gated thoracic magnetic resonance angiography at 3T: noncontrast versus blood pool contrast.

3T 门控胸部磁共振血管造影：非造影剂与血池造影剂。

• DOI: 10.1007/s10554-017-1242-8
• 发表时间: 2018
• 期刊: The international journal of cardiovascular imaging
• 作者: Zhu,Chengcheng;Haraldsson,Henrik;Kallianos,Kimberly;Ge,Liang;Tseng,Elaine;Henry,Travis;Saloner,David;Hope,MichaelD
• 通讯作者: Hope,MichaelD