Preventing Alcohol and Other Drug Use and Violence among Latino Youth

在拉美裔青年中预防酗酒和其他药物使用和暴力 项目摘要/摘要 这项K01研究和培训奖推进了我的长期目标，即开发旨在 美国拉美裔青少年中酒精和其他药物(AOD)的使用和暴力。青少年AOD 吸毒和暴力是密切相关的，因为有证据清楚地表明，青少年AOD使用者更多 有可能实施暴力，急性醉酒和长期使用都与攻击有关。此外， 前瞻性研究的结果表明，青少年参与暴力也预示着随后的AOD使用。 拉丁裔早期青少年(11至14岁)不成比例地面临饮酒和参与暴力活动的风险 行为。然而，仍然迫切需要开发易于扩展的、预防性的干预措施-- 针对拉美裔青年使用AOD和暴力的运动。拟议的研究计划侧重于适应 经验支持的AOD使用干预(保持真实[KIR])以包括对暴力的关注，进而， 测试适应的预防性干预措施，以检查其可行性、可接受性和初步效果。这个 建议的多学科培训计划旨在帮助我发展必要的技能，以便有效地 发挥独立研究人员的作用，开展高影响力的翻译研究。具体来说，这将是 包括使用定性方法为适应和发展干预措施提供信息的培训， 有系统地调整/制定干预措施的过程，最后是测试干预措施和预防-- 结果研究。我的培训计划与这三个学习目标直接相关。在目标1中，我将进行聚焦 小组访谈旨在为KIR的改编提供信息，以便将重点放在预防暴力上。在目标2中，我 将在这一形成性研究的基础上，调整KIR，使其纳入对青少年暴力和暴力的关注 预防。在目标3中，我将领导一项试点随机对照试验(RCT)，在该试验中，适应性干预 以评估适应性干预的可行性/可接受性，并评估信号 对于AOD的使用和暴力后果，存在有效性的差异。预计拟议的研究将做出贡献。 开发一种易于扩展的、针对AOD使用和暴力的多成分预防性干预 在拉丁裔早期青少年中，可以在全功率随机对照试验(R01)中进行测试。这项研究解决了一个信号-- 在一个庞大且快速增长的少数群体中，在预防科学方面存在着巨大的差距，他们经历了多重、相互影响的 相关的健康差距。此外，K01导师研究科学家发展奖将为我提供 拥有向独立投资飞跃所需的培训、研究经验和初步数据- 鳄鱼状态。这样的经验和培训是我努力在我之前的研究基础上 这可以转化为旨在产生现实世界好处的干预研究项目。

Preventing Alcohol and Other Drug Use and Violence among Latino Youth Project Summary/Abstract This K01 research and training award advances my long-term goal of developing interventions designed to target alcohol and other drug (AOD) use and violence among Latino adolescents in the United States. Adolescent AOD use and violence are profoundly interrelated as evidence clearly indicates that adolescent AOD users are more likely to enact violence and that both acute intoxication and chronic use are related to aggression. Moreover, results from prospective studies suggest that youth involvement in violence also predicts subsequent AOD use. Latino early adolescents (ages 11 to 14) are disproportionally at risk to use alcohol and take part in violent behavior. And yet, there remains a critical need for the development of readily-scalable, preventative interven- tions that target AOD use and violence among Latino youth. The proposed research plan focuses on adapting an empirically-supported AOD use intervention (keepin' it REAL [kiR]) to include a focus on violence and, in turn, testing the adapted preventative intervention to examine its feasibility, acceptability, and preliminary effects. The proposed multidisciplinary training plan is designed to assist me in developing the necessary skills to effectively function as an independent researcher and carry out high-impact translational research. Specifically, this will include training in the use of qualitative methods to inform the adaptation and development of interventions, the process of systematically adapting/developing interventions, and, finally, the testing of interventions and preven- tion outcomes research. My training plan is directly linked to the three study aims. In Aim 1, I will conduct focus group interviews designed to inform the adaptation of kiR to include a focus on violence prevention. In Aim 2, I will build upon this formative research by adapting kiR to incorporate a focus on youth violence and violence prevention. And, in Aim 3, I will lead a pilot randomized controlled trial (RCT) in which the adapted intervention is tested in order to assess the feasibility/acceptability of the adapted intervention and assess whether a signal of efficacy is present for AOD use and violence outcomes. The contribution of the proposed research is expected to be the development of a readily-scalable, multicomponent preventative intervention for AOD use and violence among Latino early adolescents that can be tested in a fully-powered RCT (R01). This study addresses a signif- icant gap in prevention science among a large and rapidly-growing minority group experiencing multiple, inter- related health disparities. Moreover, this K01 Mentored Research Scientist Development Award will provide me with the training, research experience, and preliminary data necessary to make the leap to independent investi- gator status. Such experience and training is foundational in my effort to build upon my prior research in ways that can translate into intervention research projects designed to yield real-world benefits.