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The Molecular Underpinnings of Complex Social Behavior

复杂社会行为的分子基础

基本信息

批准号：
10457297
负责人：
Daniel Kronauer
金额：
$ 42.38万
依托单位：
ROCKEFELLER UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10457297
关键词：
Affect Ants Behavior Behavioral Behavioral Assay Behavioral Genetics Biogenic Amines Biological Biological Models Biology Brain CRISPR/Cas technology Chemicals Communication Complex Computer Vision Systems Cues DNA DNA Methylation Defect Development Disease Environment Epigenetic Process Facial Expression Genetic Genetic study Histones Human Impairment Individuality Insecta Language Light Lobe Mammals Maps Measures Mental Depression Modeling Molecular Monitor Mood Disorders Neurobiology Neurodevelopmental Disorder Neuromodulator Neuropeptides Organism Performance Pharmacology Process Research Resources Rodent Social Behavior Social Environment Social Interaction Societies System Transgenic Organisms Work autism spectrum disorder communication behavior fly innovation insight knockout gene neurobiological mechanism novel social social cognition social group tool

项目摘要

Humans are highly social. Our brains have evolved to recognize and interpret the expression of faces and to produce and process language. Our behavior is modulated by our social interactions, and defects in social cognition manifest themselves in various disorders, including depression and autism. However, it has remained challenging to model these conditions in classic genetic systems such as rodents and flies because they only display basic social behaviors. Social insects such as ants, on the other hand, have evolved sophisticated societies and social behaviors, including nestmate recognition and complex communication via chemical cues. Their behavior is contingent on the social environment, giving rise to cooperation and division of labor. We study ants to understand the basic genetic and neurobiological mechanisms underlying these phenomena. Because most of the molecules that modulate social behavior, such as neuropeptides, biogenic amines, and epigenetic marks on DNA and histones are conserved from insects to mammals, many of the insights gained from ants will also be applicable to humans. Over the past five years we have developed tools for the clonal raider ant Ooceraea biroi, a species that combines complex social insect biology with unprecedented experimental control. We can now monitor social behavior using computer vision, measure, map, and pharmacologically manipulate candidate neuromodulators in the ant brain, and create stable gene knockout and transgenic lines using CRISPR technology. We will study the development, organization and activity of the ant antennal lobe, the part of the brain that processes the ants' sophisticated chemical language. We will also conduct a large unbiased screen to identify candidate neuromodulators that affect social behavior. We will then manipulate these candidates pharmacologically and genetically to describe their function in more detail. We will also genetically disrupt DNA methylation, a common epigenetic mark implicated in behavioral individuality and plasticity. Finally, we will study how communication and social behavior affect the performance of social groups in dynamic and challenging external environments. This work will elucidate how, on a molecular level, the brains of social partners interact. This work is innovative because it uses a novel and uniquely suited study species to take a complementary approach to important biological questions of biomedical relevance. It will produce additional tools and resources to further establish the clonal raider ant as a model system for behavioral genetics, and it will shed light on the molecular mechanisms underlying social behavior, which can then be studied further in other species including humans.

人类具有高度的社会性。我们的大脑已经进化到能够识别和解释面孔，并产生和处理语言。我们的行为受到我们的社交活动的影响相互作用和社会认知缺陷表现在各种障碍中，包括抑郁症和自闭症。然而，对这些情况进行建模仍然具有挑战性经典的遗传系统，如啮齿动物和苍蝇，因为它们只显示了基本的社会行为。另一方面，蚂蚁等群居昆虫进化出了复杂的社会和社会行为，包括鸟巢识别和通过化学物质进行复杂的交流暗示。他们的行为取决于社会环境，导致合作和分工。我们研究蚂蚁是为了了解基本的遗传和神经生物学这些现象背后的机制。因为大多数调节社会的分子行为，如神经肽、生物胺和DNA和组蛋白上的表观遗传标记从昆虫到哺乳动物都是保守的，从蚂蚁那里获得的许多见解也将适用于人类。在过去的五年里，我们开发了克隆袭击者蚂蚁的工具 Ooceraea biroi，一个将复杂的社会昆虫生物学与史无前例的实验对照。我们现在可以使用计算机视觉、测量、 MAP，并在药理学上操纵蚂蚁大脑中的候选神经调节剂，并创造利用CRISPR技术获得稳定的基因敲除和转基因株系。我们会研究蚂蚁触角叶的发育、组织和活动，这是大脑中负责处理蚂蚁复杂的化学语言。我们还将不偏不倚地进行大规模的筛选出影响社会行为的候选神经调节剂。到时候我们会的在药理学和遗传学上操纵这些候选基因，以描述它们在更多细节。我们还将从基因上扰乱DNA甲基化，这是一种常见的表观遗传标记与行为个性和可塑性有关。最后，我们将研究如何进行沟通而社会行为影响着社会群体在动态和具有挑战性的外部环境中的表现环境。这项工作将在分子水平上阐明社会伴侣的大脑是如何互动。这项工作具有创新性，因为它使用了一种新颖而独特的研究物种来对与生物医学相关的重要生物学问题采取互补的方法。会的提供更多工具和资源，以进一步建立克隆袭击者蚂蚁作为模型行为遗传学系统，它将阐明潜在的分子机制社会行为，然后可以在包括人类在内的其他物种中进一步研究。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Response thresholds alone cannot explain empirical patterns of division of labor in social insects.

DOI：
10.1371/journal.pbio.3001269
发表时间：
2021-06
期刊：
PLoS biology
影响因子：
9.8
作者：
Ulrich Y;Kawakatsu M;Tokita CK;Saragosti J;Chandra V;Tarnita CE;Kronauer DJC
通讯作者：
Kronauer DJC

An oxytocin/vasopressin-related neuropeptide modulates social foraging behavior in the clonal raider ant.

DOI：
10.1371/journal.pbio.3001305
发表时间：
2021-06
期刊：
PLoS biology
影响因子：
9.8
作者：
Fetter-Pruneda I;Hart T;Ulrich Y;Gal A;Oxley PR;Olivos-Cisneros L;Ebert MS;Kazmi MA;Garrison JL;Bargmann CI;Kronauer DJC
通讯作者：
Kronauer DJC

anTraX, a software package for high-throughput video tracking of color-tagged insects.

DOI：
10.7554/elife.58145
发表时间：
2020-11-19
期刊：
eLife
影响因子：
7.7
作者：
Gal A;Saragosti J;Kronauer DJ
通讯作者：
Kronauer DJ

A caste differentiation mutant elucidates the evolution of socially parasitic ants.

DOI：
10.1016/j.cub.2023.01.067
发表时间：
2023-03-27
期刊：
CURRENT BIOLOGY
影响因子：
9.2
作者：
Trible, Waring;Chandra, Vikram;Lacy, Kip D.;Limon, Gina;McKenzie, Sean K.;Olivos-Cisneros, Leonora;Arsenault, Samuel V.;Kronauer, Daniel J. C.
通讯作者：
Kronauer, Daniel J. C.

Unselfish meiotic drive maintains heterozygosity in a parthenogenetic ant.

无私的减数分裂驱动力维持孤雌蚂蚁的杂合性。