Pediatric HIV/AIDS Cohort Study (PHACS) 2020
儿科艾滋病毒/艾滋病队列研究 (PHACS) 2020
基本信息
- 批准号:10465786
- 负责人:
- 金额:$ 45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-18 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:13 year oldAddressAdolescentAdolescent and Young AdultAdultAgeAgingAnti-Retroviral AgentsBrainBrain regionCaringCenters for Disease Control and Prevention (U.S.)Cervical Intraepithelial NeoplasiaChildChild HealthCognitiveCohort StudiesCommunitiesData AnalysesDevelopmentDiseaseDisease remissionEffectivenessEpidemiologic MethodsEpidemiologyExposure toGrantGrowthGuidelinesHIVHIV InfectionsHPV-High RiskHealthHealth behaviorHealth educationHuman PapillomavirusHuman papilloma virus infectionIndividualInfantInfant HealthInfectionInfrastructureLife Cycle StagesLong-Term EffectsMonitorNatural HistoryNeurologicOral healthOutcomePediatric HIV/AIDS Cohort StudyPerinatalPersonsPharmaceutical PreparationsPopulationPregnant WomenPrevalencePreventionProgram Research Project GrantsProspective cohort studyProtocols documentationResearch Project GrantsRiskRisk FactorsSafetySeriesSiteStatistical MethodsTestingToxic effectVaccinatedYouthadverse birth outcomesbehavioral outcomecardiometabolismclinical research sitecohortdata managementdata resourcedesignemotion regulationemotional behaviorexperiencein uteromultidisciplinaryneurodevelopmentoral HPVperinatal HIVpostnatalprogramsreproductivesocial structuresuccesssurveillance studytransmission processtreatment responseyoung adultyoung manyoung woman
项目摘要
Project Summary/Abstract
Each year, there are more than 1 million pregnant women living with HIV (PWLHIV) who receive antiretroviral
medications (ARVs) for treatment and perinatal and postnatal HIV transmission prevention, with new ARVs
introduced at a rapid pace. Although maternal use of ARVs has successfully reduced perinatal HIV
transmission, there remains a clear need to monitor the safety of in utero ARV for infant and child health.
Currently, 1.7 million children under the age of 15 are living with HIV globally – the vast majority with perinatally
acquired HIV infection (PHIV) - who are aging into young adulthood. In the US, the Centers for Disease Control
and Prevention (CDC) estimates that in 2016, there were 11,915 persons with PHIV in the U.S, including 1,814
children younger than 13 years of age and 10,101 adolescents and young adults. The lifelong impact of HIV
and ARVs on their overall health is unknown as they transition into adulthood and adult HIV care.
The Pediatric HIV/AIDS Cohort Study (PHACS) is a network, initiated in 2007, currently consisting of two
prospective cohort studies: The Surveillance Monitoring for ART Toxicities Study (SMARTT), with over
4,000 infants, children and youth with perinatal HIV exposure but who are uninfected (PHEU), and the series of
Adolescent Master Protocols (AMP, AMP Up and AMP Up Lite) studies following 1,000 young adults with
perinatal HIV, and a comparison cohort of young adults with PHEU. These studies are designed to answer
questions regarding the short and long term outcomes of HIV infection and ARV exposure or treatment.
PHACS 2020 is designed as a Program Project P01 grant, consisting of the following four support Cores:
Scientific Administrative Core (SAC), Data Resources Core (DRC), Health Education and Community Core
(HECC), and the Epidemiological and Statistical Methods Core (ESC) to provide scientific, site and cohort
infrastructure, data management and analysis, health education and community input, as well as
epidemiological and statistical support to four Research Projects: 1) SMARTT; 2) The Adolescent Master
Protocol (AMP) Up Series (the AMP Up Series); 3) Natural History of Cervical Intraepithelial Neoplasia
(CIN) and Human Papillomavirus (HPV) in HPV Vaccinated Youth with PHIV (HPV); and the TERBO
BRAIN Study: Trajectories of Emotional Regulation and Behavior Outcomes and related Brain Regions
And Intrinsic Networks (TERBO BRAIN). This multidisciplinary, interdisciplinary, transdisciplinary and
synergistic P01 will address the most critical scientific questions for children, youth and young adults exposed
to or living with HIV.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ellen Gould Chadwick其他文献
Pyoderma gangrenosum in pediatric acquired immunodeficiency syndrome
- DOI:
10.1016/s0022-3476(05)82444-8 - 发表时间:
1990-07-01 - 期刊:
- 影响因子:
- 作者:
Amy S. Paller;Eleanor E. Sahn;Paul D. Garen;Richard L. Dobson;Ellen Gould Chadwick - 通讯作者:
Ellen Gould Chadwick
Influenza Vaccination in HIV-Infected Children: Serologic Response, Viral Load Changes and Effect of Vitamin A Supplementation ♦ 844
人类免疫缺陷病毒感染儿童的流感疫苗接种:血清学反应、病毒载量变化及维生素 A 补充的效果♦844
- DOI:
10.1203/00006450-199804001-00865 - 发表时间:
1998-04-01 - 期刊:
- 影响因子:3.100
- 作者:
Willem A Hanekom;Lynn M Heald;Greg D Hussey;Ram Yogev;Kathryn M Edwards;Ellen Gould Chadwick - 通讯作者:
Ellen Gould Chadwick
Ellen Gould Chadwick的其他文献
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{{ truncateString('Ellen Gould Chadwick', 18)}}的其他基金
Pediatric HIV/AIDS Cohort Study (PHACS) 2020
儿科艾滋病毒/艾滋病队列研究 (PHACS) 2020
- 批准号:
10290224 - 财政年份:2021
- 资助金额:
$ 45万 - 项目类别:
Pediatric HIV/AIDS Cohort Study (PHACS) 2020
儿科艾滋病毒/艾滋病队列研究 (PHACS) 2020
- 批准号:
10663894 - 财政年份:2020
- 资助金额:
$ 45万 - 项目类别:
Health Outcomes around Pregnancy and Exposure to HIV/ARV (HOPE): Extending the Reach of PHACS to Examine Women's Health
围绕怀孕和接触 HIV/ARV 的健康结果 (HOPE):扩大 PHACS 的范围以检查女性健康
- 批准号:
10249082 - 财政年份:2020
- 资助金额:
$ 45万 - 项目类别:
Pediatric HIV/AIDS Cohort Study (PHACS) 2020
儿科艾滋病毒/艾滋病队列研究 (PHACS) 2020
- 批准号:
10391037 - 财政年份:2020
- 资助金额:
$ 45万 - 项目类别:
Health Outcomes around Pregnancy and Exposure to HIV/ARV (HOPE): Extending the Reach of PHACS to Examine Women's Health
围绕怀孕和接触 HIV/ARV 的健康结果 (HOPE):扩大 PHACS 的范围以检查女性健康
- 批准号:
10437910 - 财政年份:2020
- 资助金额:
$ 45万 - 项目类别:
Pediatric HIV/AIDS Cohort Study (PHACS) 2020
儿科艾滋病毒/艾滋病队列研究 (PHACS) 2020
- 批准号:
10065440 - 财政年份:2020
- 资助金额:
$ 45万 - 项目类别:
Pediatric HIV/AIDS Cohort Study (PHACS) 2020
儿科艾滋病毒/艾滋病队列研究 (PHACS) 2020
- 批准号:
10264949 - 财政年份:2020
- 资助金额:
$ 45万 - 项目类别:
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