Pediatric HIV/AIDS Cohort Study (PHACS) 2020

项目摘要/摘要 每年有100多万名携带艾滋病毒(PWLHIV)的孕妇接受抗逆转录病毒治疗 用于治疗和预防围产期和产后艾滋病毒传播的药物(ARV)，以及新的ARV 以快速的步伐引入。尽管母亲使用抗逆转录病毒药物成功地减少了围产期艾滋病毒 尽管存在传播风险，但显然仍有必要监测宫内抗逆转录病毒的安全性，以保障婴儿和儿童的健康。 目前，全球有170万15岁以下的儿童感染艾滋病毒--其中绝大多数是围产期感染的 获得性艾滋病毒感染(PHIV)--他们正在进入青壮年。在美国，疾病控制中心 美国疾病控制与预防中心(CDC)估计，2016年美国有11,915名艾滋病毒携带者，其中包括1,814人 13岁以下儿童和10,101名青少年和青壮年。艾滋病毒的终生影响 在他们进入成年期和成人艾滋病毒护理的过程中，抗逆转录病毒药物对他们整体健康的影响尚不清楚。 儿科艾滋病毒/艾滋病队列研究(PHACS)是一个网络，成立于2007年，目前由两个 前瞻性队列研究：抗逆转录病毒药物毒性监测研究(SMART) 4,000名围产期感染艾滋病毒但未感染的婴儿、儿童和青年(PHEU)，以及一系列 青少年主程序(AMP、AMP UP和AMP UP Lite)研究 围产期艾滋病毒，以及患有PHEU的年轻人的比较队列。这些研究旨在回答 关于艾滋病毒感染和ARV暴露或治疗的短期和长期结果的问题。 PHACS 2020是作为P01项目赠款计划设计的，由以下四个支持核心组成： 科学管理核心(SAC)、数据资源核心(DRC)、健康教育和社区核心 (HECC)以及流行病学和统计方法核心(ESC)，以提供科学、现场和队列 基础设施、数据管理和分析、健康教育和社区投入以及 对四个研究项目的流行病学和统计学支持：1)SMARTT；2)青少年大师 协议(AMP)UP系列(AMP UP系列)；3)宫颈上皮内瘤变的自然病史 人类乳头瘤病毒(HPV)疫苗接种感染PHIV的青少年中的CIN和HPV；以及TERBO 大脑研究：情绪调节和行为结果的轨迹以及相关的大脑区域 和内在网络(TERBO大脑)。这种多学科、跨学科、跨学科和 Synergistic P01将解决儿童、青少年和年轻人面临的最关键的科学问题 感染或携带艾滋病毒的。

Project Summary/Abstract Each year, there are more than 1 million pregnant women living with HIV (PWLHIV) who receive antiretroviral medications (ARVs) for treatment and perinatal and postnatal HIV transmission prevention, with new ARVs introduced at a rapid pace. Although maternal use of ARVs has successfully reduced perinatal HIV transmission, there remains a clear need to monitor the safety of in utero ARV for infant and child health. Currently, 1.7 million children under the age of 15 are living with HIV globally – the vast majority with perinatally acquired HIV infection (PHIV) - who are aging into young adulthood. In the US, the Centers for Disease Control and Prevention (CDC) estimates that in 2016, there were 11,915 persons with PHIV in the U.S, including 1,814 children younger than 13 years of age and 10,101 adolescents and young adults. The lifelong impact of HIV and ARVs on their overall health is unknown as they transition into adulthood and adult HIV care. The Pediatric HIV/AIDS Cohort Study (PHACS) is a network, initiated in 2007, currently consisting of two prospective cohort studies: The Surveillance Monitoring for ART Toxicities Study (SMARTT), with over 4,000 infants, children and youth with perinatal HIV exposure but who are uninfected (PHEU), and the series of Adolescent Master Protocols (AMP, AMP Up and AMP Up Lite) studies following 1,000 young adults with perinatal HIV, and a comparison cohort of young adults with PHEU. These studies are designed to answer questions regarding the short and long term outcomes of HIV infection and ARV exposure or treatment. PHACS 2020 is designed as a Program Project P01 grant, consisting of the following four support Cores: Scientific Administrative Core (SAC), Data Resources Core (DRC), Health Education and Community Core (HECC), and the Epidemiological and Statistical Methods Core (ESC) to provide scientific, site and cohort infrastructure, data management and analysis, health education and community input, as well as epidemiological and statistical support to four Research Projects: 1) SMARTT; 2) The Adolescent Master Protocol (AMP) Up Series (the AMP Up Series); 3) Natural History of Cervical Intraepithelial Neoplasia (CIN) and Human Papillomavirus (HPV) in HPV Vaccinated Youth with PHIV (HPV); and the TERBO BRAIN Study: Trajectories of Emotional Regulation and Behavior Outcomes and related Brain Regions And Intrinsic Networks (TERBO BRAIN). This multidisciplinary, interdisciplinary, transdisciplinary and synergistic P01 will address the most critical scientific questions for children, youth and young adults exposed to or living with HIV.