System-independent quantitative cardiac CT perfusion

非系统依赖性定量心脏CT灌注 第二阶段，SBIR 总结 BioInVision，Inc.凯斯西储大学（CWRU）生物医学工程师和大学 医院克利夫兰医学中心（UH）成像心脏病学家-将开发定量分析软件 心脏CT灌注（CCTP）数据的实时性，为心血管疾病的评估创造了一个重要工具。与 心脏病专家将能够识别冠状动脉区域的功能性血流缺损。当一个 将功能性心肌血流量（MBF）功能与冠状动脉解剖结构相结合，从冠状动脉计算到- 运动造影血管造影术（CCTA），它提供了狭窄的生理意义所需的信息。 CCTP+CCTA组合可以提供一种理想的网关检查，用于决定是否将患者送往 经皮侵入性冠状动脉血管造影术和潜在的介入（例如，支架植入术）。此外，低流量- 狭窄的存在表明微血管疾病，一种越来越受到关注的非常普遍的疾病， 尤其是在妇女和糖尿病患者中。CT优于所有其他非侵入性心血管检查 成像技术（SPECT、PET和MRI）。它适用于许多环境，包括急诊室， 并且与其它方法相比是高通量的。它提供MBF和可靠的冠状动脉解剖结构， 在任何其他单一模态中不可用，提供了一种独特的非侵入性区分心脏的能力， 微血管疾病它具有出色的分辨率，能够检测血管内灌注不足， 是SPECT无法评估的早期疾病指标。CT更便宜，患者更高 与MRI或PET相比，随着医疗保险基金的纳入，CT将有一个很好的机会来破坏 导致经皮介入的诊断途径，这是一条由SPECT my主导的途径， 冠状动脉成像，一种提供关于冠状动脉解剖结构的零信息的模式。实现可靠、准确 CT MBF测量，我们将援引创新，以减少射束硬化，并作出可靠的流量估计， 伙计们目前，CT灌注是在不同的CT机上使用制造商的专有软件完成的， 可能给出错误MBF的算法。适用于任何商业扫描仪;我们的解决方案将协调 跨采集系统的测量为临床医生提供值得信赖的标准化测量， 从而改善心血管病人的管理。

System-independent quantitative cardiac CT perfusion Phase II, SBIR Summary BioInVision, Inc. and team - Case Western Reserve University (CWRU) biomedical engineers and University Hospitals Cleveland Medical Center (UH) imaging cardiologists - will develop software for quantitative analysis of cardiac CT perfusion (CCTP) data, creating an important tool for evaluation of cardiovascular disease. With this product, cardiologists will be able to identify functional flow deficits in coronary artery territories. When one combines functional myocardial blood flow (MBF) function with coronary anatomy from coronary computed to- mography angiography (CCTA), it provides needed information on the physiologic significance of a stenosis. The CCTP+CCTA combination could provide an ideal gateway exam for deciding whether to send a patient for percutaneous invasive coronary angiography and potential intervention (e.g., stenting). In addition, low flow with- out the presence of a stenosis suggests microvascular disease, a very prevalent ailment of growing concern, especially among women and diabetes patients. CT compares favorably to all other non-invasive cardiovascular imaging techniques (SPECT, PET, and MRI). It is available in many settings, including emergency departments, and is high throughput as compared to other methods. It provides both MBF and reliable coronary anatomy, with are unavailable in any other single modality, providing a unique ability to non-invasively discriminate cardiac microvascular disease. It has excellent resolution enabling detection of endocardial perfusion deficit, thought to be an early disease indicator that is impossible to assess with SPECT. CT is cheaper and has higher patient throughput than MRI or PET. With the inclusion of MBF, CT would have an excellent opportunity to disrupt the diagnostic pathway leading to percutaneous intervention, a pathway which has been dominated by SPECT my- ocardial imaging, a modality that gives zero information about coronary anatomy. To achieve reliable, accurate CT MBF measurements, we will invoke innovations to reduce beam hardening and to make reliable flow esti- mates. Currently, CT perfusion is done on different CT machines with manufacturers’ proprietary software, using algorithms that can give erroneous MBFs. Applicable to any commercial scanner; our solution would harmonize measurements across acquisition systems providing trustworthy, standardized measurements to clinicians, thereby improving management of cardiovascular patients.