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中文摘要
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项目概要/摘要 项目总监托马斯J.霍普博士根据以下内容组建了该拟议PPG的调查团队: 每个项目/核心领导人和共同研究者的才能和专业知识。这支队伍完全有能力 该计划的总体目标是“解开艾滋病毒持续存在和反弹的机制”,重点是 利用创新的技术进步以及团队和外部的最新数据和发现 合作者核心的主要重点将是促进科学的协同作用和新知识的发现。 行政核心(核心A)将作为本计划的集中资源发挥关键作用, 提供全面的管理,协调和监督计划,同时促进 3个项目和NHP核心(核心B)之间的相互作用,以保证该综合计划的 成功实现其目标。行政核心将位于NU,并将在 Hope博士作为项目总监(PD)的直接指导。 行政核心将提供支持所有项目的基本功能互动基础设施 和科学核心与计划管理,包括频繁和及时的沟通平台,资源 和数据交换,时间轴和财政监督,对研究进展的严格审查,以及与 更广泛的艾滋病毒/艾滋病研究界,以确保PPG科学目标的成功。通过促进高效 以及所有研究者之间频繁的沟通和反复的互动,无论是初级还是高级, AC将通过使PI能够积极主动地结合进步并避免 他们的同事在这3个高度互动的项目中发现了计划外的障碍
英文摘要
PROJECT SUMMARY/ABSTRACT Thomas J. Hope, PhD, Program Director has assembled the investigative team for this proposed PPG based on the talents and expertise of each project/core leader and co-investigator. This team is perfectly posed to address the overall aim of the program to “unravel the mechanisms of HIV persistence and rebound” by focusing on leveraging innovative technical advances as well as the latest data and findings by the team and outside collaborators. The Core main focus will be to stimulate scientific synergism and the discovery of new knowledge. The Administrative Core (Core A) will serve a critical function as a centralized resource to the Program, providing for the overall management, coordination, and supervision of the Program, while facilitating the interactions between the 3 Projects and the NHP Core (Core B), to guarantee this integrated Program’s success in achieving its objective. The Administrative Core will be located at NU and will be operated under the direct guidance of Dr. Hope as Program Director (PD). The administrative core will provide the essential, functionally-interactive infrastructure supporting all projects and scientific cores with program management including frequent and timely communication platforms, resource and data exchange, timeline and fiscal oversight, critical review of research progress, and engagement with the broader HIV/AIDS research community to ensure the success of the PPG scientific goals. By facilitating efficient and frequent communications as well as iterative interactions between all investigators, both junior and senior, the AC will catalyze PPG progress by enabling PIs to proactively incorporate the advances and avoid the unplanned hurdles discovered by their colleagues in this highly interactive set of 3 projects
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Project 1: Dissecting Persistent Virus Reservoirs in Tissues
Role of myeloid cells in CNS and systemic reservoirs and rebound
Identification of the Initial Targets of Transmission
Project 1: Dissecting Persistent Virus Reservoirs in Tissues
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