Cardiovascular Benefits of Inhaled Biogenic Volatile Organic Compounds

项目主任/首席研究员(最后、第一、中间)：Conklin，Daniel J.，博士 摘要 广泛的流行病学证据表明，接触植被和居住环境接近 绿地可以降低各种原因导致的死亡、心血管疾病、焦虑、抑郁和攻击的风险。 尽管有人建议城市绿地通过去除空气污染物来发挥其有益的作用 和促进身体活动，植物释放生物来源的挥发性有机化合物(BVOCs)，通过诱导 有益的心血管和神经效应可以调节植物的有益作用。植被是 自然环境的一个主要未被重视的领域，人们对它的兴趣有限。暴露于 自然环境中的绿色空间与心血管健康的改善有关。我们 提出植物来源的BVOCs包括松烯、柠檬烯和香茅醇刺激不同的信号转导。 部分通过激活心血管上的瞬时受体潜在锚蛋白-1(TRPA1)通道 目标。例如，在内皮细胞中，TRPA1的激活会释放一氧化氮，从而降低血压， 改善心血管功能，抑制炎症和血栓形成，导致总体下降 在心血管疾病风险方面。该项目的完成将严格确立有益于心血管的作用 人类环境中普遍存在的可吸入的BVOCs。此外，我们的研究将提供第一个测试 假设吸入的BVOCs的有益作用部分是由TRPA1介导的。这些临床前研究 也可能导致暴露于绿色的生物标记物的发展，这可能在临床上有用 评价绿色(如植树)在降低人类心血管疾病风险方面的潜在治疗作用 人口。 PHS 398/2590(06/09版)页面续格式页面

Program Director/Principal Investigator (Last, First, Middle): Conklin, Daniel J., Ph.D. ABSTRACT Extensive epidemiological evidence suggests that exposure to vegetation and residential proximity to greenspaces lowers the risk of all-cause mortality, cardiovascular disease, anxiety, depression and aggression. Although it has been suggested that urban greenspaces exert their beneficial effects by removing air pollutants and promoting physical activity, plants emit biogenic volatile organic chemicals (BVOCs), which by eliciting beneficial cardiovascular and neurological effects could mediate the salutary effects of vegetation. Vegetation is a major underappreciated domain of the natural environment that has received limited interest. Exposure to greenspace within the natural environment has been linked to improvements in cardiovascular health. We propose that plant-derived BVOCs including pinenes, limonene, and citronellol stimulate distinct signaling pathways, in part, by activating the transient receptor potential ankyrin-1 (TRPA1) channel on cardiovascular targets. In endothelial cells, for example, activation of TRPA1 releases nitric oxide that lowers blood pressure, improves cardiovascular function and tamps down inflammation and thrombosis leading to an overall decrease in cardiovascular disease risk. Completion of this project will rigorously establish beneficial cardiovascular effects of inhaled BVOCs that are prevalent in human environments. Moreover, our studies will provide a first test of hypothesis that beneficial effects of inhaled BVOCs are mediated, in part, by TRPA1. These preclinical studies may also lead to the development of biomarkers of exposure to greenness, which likely will be useful in clinical evaluation of the potential therapeutic use of greenness (e.g., planting trees) to decrease CVD risk in human populations. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page