Cardiovascular Benefits of Inhaled Biogenic Volatile Organic Compounds
吸入生物挥发性有机化合物对心血管的益处
基本信息
- 批准号:10459548
- 负责人:
- 金额:$ 19.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:ANK1 geneAcuteAdultAffectAggressive behaviorAir PollutantsAnti-Inflammatory AgentsAntiinflammatory EffectAnxietyAttentionBlood PressureBlood VesselsCardiacCardiovascular DiseasesCardiovascular PhysiologyCardiovascular systemCell physiologyCellsChemical ExposureChrysanthemumCypressDataDoctor of PhilosophyEndothelial CellsEndotheliumEnvironmentEnvironmental Risk FactorEpidemiologyEucalyptolExposure toFemaleFrequenciesFutureGreen spaceHealthHeart RateHumanInflammationInflammatoryInhalationIntravenousJuniperKnowledgeLeadLife StyleLinkMalignant NeoplasmsMass Spectrum AnalysisMediatingMental DepressionMetabolismMolecularMonoterpenesMusNational Institute of Environmental Health SciencesNeurologic EffectNitric OxideOralPathway interactionsPharmacologyPhysical activityPhysiologicalPlantsPopulationPrincipal InvestigatorProductionRadioRattusRiskRoleScreening procedureShapesSignal PathwaySignal TransductionSleepStressTRPA channelTelemetryTestingTherapeutic UsesThrombosisTimeTreesUnited StatesVasodilationWorkaerosolizedanti-cancerbiomarker developmentblood pressure reductioncardioprotectioncardiovascular disorder riskcardiovascular effectscardiovascular healthdosimetryheart rate variabilityhemodynamicshypertensiveimprovedin vitro Assayindoor airinterestlifestyle factorslimonenelinaloolmalemortalitynormotensivepreclinical studypreventprogramsreceptorresearch clinical testingurinaryvolatile organic compound
项目摘要
Program Director/Principal Investigator (Last, First, Middle): Conklin, Daniel J., Ph.D.
ABSTRACT
Extensive epidemiological evidence suggests that exposure to vegetation and residential proximity to
greenspaces lowers the risk of all-cause mortality, cardiovascular disease, anxiety, depression and aggression.
Although it has been suggested that urban greenspaces exert their beneficial effects by removing air pollutants
and promoting physical activity, plants emit biogenic volatile organic chemicals (BVOCs), which by eliciting
beneficial cardiovascular and neurological effects could mediate the salutary effects of vegetation. Vegetation is
a major underappreciated domain of the natural environment that has received limited interest. Exposure to
greenspace within the natural environment has been linked to improvements in cardiovascular health. We
propose that plant-derived BVOCs including pinenes, limonene, and citronellol stimulate distinct signaling
pathways, in part, by activating the transient receptor potential ankyrin-1 (TRPA1) channel on cardiovascular
targets. In endothelial cells, for example, activation of TRPA1 releases nitric oxide that lowers blood pressure,
improves cardiovascular function and tamps down inflammation and thrombosis leading to an overall decrease
in cardiovascular disease risk. Completion of this project will rigorously establish beneficial cardiovascular effects
of inhaled BVOCs that are prevalent in human environments. Moreover, our studies will provide a first test of
hypothesis that beneficial effects of inhaled BVOCs are mediated, in part, by TRPA1. These preclinical studies
may also lead to the development of biomarkers of exposure to greenness, which likely will be useful in clinical
evaluation of the potential therapeutic use of greenness (e.g., planting trees) to decrease CVD risk in human
populations.
PHS 398/2590 (Rev. 06/09) Page Continuation Format Page
项目主任/首席研究员(最后、第一、中间):Conklin,Daniel J.,博士
摘要
广泛的流行病学证据表明,接触植被和居住环境接近
绿地可以降低各种原因导致的死亡、心血管疾病、焦虑、抑郁和攻击的风险。
尽管有人建议城市绿地通过去除空气污染物来发挥其有益的作用
和促进身体活动,植物释放生物来源的挥发性有机化合物(BVOCs),通过诱导
有益的心血管和神经效应可以调节植物的有益作用。植被是
自然环境的一个主要未被重视的领域,人们对它的兴趣有限。暴露于
自然环境中的绿色空间与心血管健康的改善有关。我们
提出植物来源的BVOCs包括松烯、柠檬烯和香茅醇刺激不同的信号转导。
部分通过激活心血管上的瞬时受体潜在锚蛋白-1(TRPA1)通道
目标。例如,在内皮细胞中,TRPA1的激活会释放一氧化氮,从而降低血压,
改善心血管功能,抑制炎症和血栓形成,导致总体下降
在心血管疾病风险方面。该项目的完成将严格确立有益于心血管的作用
人类环境中普遍存在的可吸入的BVOCs。此外,我们的研究将提供第一个测试
假设吸入的BVOCs的有益作用部分是由TRPA1介导的。这些临床前研究
也可能导致暴露于绿色的生物标记物的发展,这可能在临床上有用
评价绿色(如植树)在降低人类心血管疾病风险方面的潜在治疗作用
人口。
PHS 398/2590(06/09版)页面续格式页面
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Daniel Joseph Conklin其他文献
Daniel Joseph Conklin的其他文献
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{{ truncateString('Daniel Joseph Conklin', 18)}}的其他基金
Cardiovascular Benefits of Inhaled Biogenic Volatile Organic Compounds
吸入生物挥发性有机化合物对心血管的益处
- 批准号:
10288039 - 财政年份:2021
- 资助金额:
$ 19.56万 - 项目类别:
Novel Treatments of Acrolein-induced Cardiotoxicity
丙烯醛引起的心脏毒性的新疗法
- 批准号:
8610016 - 财政年份:2013
- 资助金额:
$ 19.56万 - 项目类别:
Core B: Tobacco Product Evaluation and Exposure Core
核心 B:烟草产品评估和暴露核心
- 批准号:
8595396 - 财政年份:2013
- 资助金额:
$ 19.56万 - 项目类别:
Novel Treatments of Acrolein-induced Cardiotoxicity
丙烯醛引起的心脏毒性的新疗法
- 批准号:
8740481 - 财政年份:2013
- 资助金额:
$ 19.56万 - 项目类别:
Cardioprotective Mechanisms of Glutathione S-transferase P
谷胱甘肽 S-转移酶 P 的心脏保护机制
- 批准号:
7838943 - 财政年份:2009
- 资助金额:
$ 19.56万 - 项目类别:
Cardioprotective Mechanisms of Glutathione S-transferase P
谷胱甘肽 S-转移酶 P 的心脏保护机制
- 批准号:
8212058 - 财政年份:2008
- 资助金额:
$ 19.56万 - 项目类别:
Cardioprotective Mechanisms of Glutathione S-transferase P
谷胱甘肽 S-转移酶 P 的心脏保护机制
- 批准号:
7466262 - 财政年份:2008
- 资助金额:
$ 19.56万 - 项目类别:
Cardioprotective Mechanisms of Glutathione S-transferase P
谷胱甘肽 S-转移酶 P 的心脏保护机制
- 批准号:
8053818 - 财政年份:2008
- 资助金额:
$ 19.56万 - 项目类别:
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