Cardiovascular Benefits of Inhaled Biogenic Volatile Organic Compounds

项目负责人/主要研究者（最后一位、第一位、中间一位）：Conklin，丹尼尔J.，博士 摘要 广泛的流行病学证据表明，暴露于植被和住宅附近， 绿地降低了全因死亡、心血管疾病、焦虑、抑郁和攻击性的风险。 尽管有人认为城市绿地通过清除空气污染物发挥其有益作用， 促进身体活动，植物释放生物挥发性有机化学品（BVOCs），通过引发 有益的心血管和神经作用可以调节植物的有益作用。植被 自然环境的一个主要的未被充分认识的领域，受到了有限的关注。暴露于 自然环境中的绿地与心血管健康的改善有关。我们 提出植物来源的BVOCs包括蒎烯、柠檬烯和香茅醇刺激不同的信号传导 部分通过激活瞬时受体电位锚蛋白-1（TRPA 1）通道， 目标的例如，在内皮细胞中，TRPA 1的激活释放一氧化氮，降低血压， 改善心血管功能，抑制炎症和血栓形成， 心血管疾病风险。该项目的完成将严格建立有益的心血管效应 在人类环境中普遍存在的吸入性BVOC。此外，我们的研究将提供第一个测试， 假设吸入BVOC的有益作用部分由TRPA 1介导。这些临床前研究 也可能导致暴露于绿色的生物标志物的发展，这可能在临床上有用。 评价绿色的潜在治疗用途（例如，种植树木）以降低人类CVD风险 人口数量。 PHS 398/2590（Rev.06/09）

Program Director/Principal Investigator (Last, First, Middle): Conklin, Daniel J., Ph.D. ABSTRACT Extensive epidemiological evidence suggests that exposure to vegetation and residential proximity to greenspaces lowers the risk of all-cause mortality, cardiovascular disease, anxiety, depression and aggression. Although it has been suggested that urban greenspaces exert their beneficial effects by removing air pollutants and promoting physical activity, plants emit biogenic volatile organic chemicals (BVOCs), which by eliciting beneficial cardiovascular and neurological effects could mediate the salutary effects of vegetation. Vegetation is a major underappreciated domain of the natural environment that has received limited interest. Exposure to greenspace within the natural environment has been linked to improvements in cardiovascular health. We propose that plant-derived BVOCs including pinenes, limonene, and citronellol stimulate distinct signaling pathways, in part, by activating the transient receptor potential ankyrin-1 (TRPA1) channel on cardiovascular targets. In endothelial cells, for example, activation of TRPA1 releases nitric oxide that lowers blood pressure, improves cardiovascular function and tamps down inflammation and thrombosis leading to an overall decrease in cardiovascular disease risk. Completion of this project will rigorously establish beneficial cardiovascular effects of inhaled BVOCs that are prevalent in human environments. Moreover, our studies will provide a first test of hypothesis that beneficial effects of inhaled BVOCs are mediated, in part, by TRPA1. These preclinical studies may also lead to the development of biomarkers of exposure to greenness, which likely will be useful in clinical evaluation of the potential therapeutic use of greenness (e.g., planting trees) to decrease CVD risk in human populations. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page