In-the-kNOW (Novel approaches to Optimizing Women’s Health): A mobile application to optimize HIV prevention and sexual/reproductive health communication among Black women in the Southern U.S.

在美国，黑人女性的新艾滋病毒感染率仅次于男男性行为者，黑人女性占南方（如乔治亚州）所有女性艾滋病毒确诊病例的69%。拟议研究的目的是完善和测试in- know（优化女性健康的新方法），这是一个专门为符合预科资格的黑人女性设计的循证和理论驱动的移动应用程序（应用程序）。该应用程序响应RFA-MH-21-150健康传播和服务研究的优先事项，通过结合便携，文化和上下文相关的消息传递策略。我们对符合prep资格的定义是基于疾病预防控制中心对黑人妇女的指导，即生活在艾滋病毒高流行地区的妇女（特别是格鲁吉亚的结束艾滋病毒流行管辖区：富尔顿、迪卡尔布、格威内特或科布县）。在我们的初步研究中，参与者认可我们的移动应用干预，In - know，并表达了对完全开发和集成版本的渴望。在社区参与式研究（CBPR）原则和大众传播社会认知理论（SCT-MC）的指导下，我们将通过in- know应用程序解决PrEP健康沟通差距，该应用程序提供个性化信息，以促进南方黑人妇女的艾滋病毒预防行为。我们假设，知情干预和控制条件（例如转介到疾病预防控制中心的在线艾滋病毒风险降低工具）对黑人妇女是可行的。在符合预科资格的黑人女性（18-44岁）样本中，我们提出以下目标：目标1。为符合预科资格的黑人女性完善in- know移动应用程序。采用以人为本的设计方法27，我们将在n = 10名符合预科资格的黑人女性中进行单臂技术可用性预测试，以优化应用程序的可用性、技术功能和性能。移动应用程序将根据预测试反馈进行改进。目标2。评估改进的in- know移动应用程序的可行性、可接受性和可用性。我们将采用实验（n = 20）和控制（n = 20）条件来确定应用程序和控制条件（例如，转到CDC的在线艾滋病毒风险降低工具）的可行性和可接受性（保留率和满意度）。目标2 b。确定收集次要结果测量值（如PrEP病耻感）的可行性（R01）。

Black women have the second highest rate of all new HIV infections in the U.S. after men who have sex with men, and they account for 69% of all HIV diagnoses among women in the South (e.g., Georgia). The objective of the proposed research is to refine and test in-the-kNOW (Novel approaches to Optimizing Women's Health), an evidence-based and theory-driven mobile application (app) specifically designed for PrEP-eligible Black women. This app responds to RFA-MH-21-150 Health Communication and Services Research priorities by incorporating portable, culturally- and contextually-relevant messaging strategies. Our definition of PrEP-eligible is based on CDC guidance for Black women, namely women who live in high HIV prevalence areas (specifically Ending the HIV Epidemic jurisdictions in Georgia: Fulton, Dekalb, Gwinnett, or Cobb counties). In our preliminary study, participants endorsed our mobile app intervention, in-the-kNOW, and expressed a desire for a fully developed and integrated version. Guided by Community-based Participatory Research (CBPR) principles and the Social Cognitive Theory of Mass Communication (SCT-MC), we will address the PrEP health communication gap with the in-the-Know app, which offers personalized messaging to promote HIV preventive behaviors among Black women in the South. We hypothesize that the in-the-kNOW intervention and the control condition (e.g. referral to the CDC's online HIV risk reduction tools) will be feasible to Black women. In a sample of PrEP-eligible Black women (ages 18-44), we propose the following aims: Aim 1. Refine the in-the-kNOW mobile app for PrEP-eligible Black women. Using a human-centered design approach 27, we will conduct a single-arm technology usability pretest to optimize usability, technical functionality, and performance of the app, among n = 10 PrEP-eligible Black women. The mobile app will be refined per pretest feedback. Aim 2a. Evaluate the feasibility, acceptability, and usability of the refined in-the-kNOW mobile app. We will employ experimental (n = 20) and control (n = 20) conditions to determine the feasibility and acceptability (retention rates and satisfaction) of both the app and the control condition (e.g., referral to the CDC's online HIV risk reduction tools). Aim 2b. Determine feasibility of collecting secondary outcome measures (e.g. PrEP Stigma) for a R01.