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Immunomodulation of the Tumor Microenvironment with Molecular Targeted Radiotherapy to Facilitate an Adaptive Anti-Tumor Immune Response to Combined Modality Immunotherapies

Immunomodulation of the Tumor Microenvironment with Molecular Targeted Radiotherapy to Facilitate an Adaptive Anti-Tumor Immune Response to Combined Modality Immunotherapies
通过分子靶向放疗对肿瘤微环境进行免疫调节,促进联合免疫疗法的适应性抗肿瘤免疫反应
批准号:
10459937
负责人:
Zachary Scott Morris
金额:
$16.52万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-18 至 2023-08-31

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英文摘要
ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT- CA-21-083. In our Cancer Moonshot IOTN U01 award, we are developing a combined modality therapeutic approach to eradicating metastatic cancers that are immunologically “cold” and do not respond to immune checkpoint inhibition (ICI). To advance the objectives of that award and to broadly define the radiosensitivity and immuno-radiobiology of immune cell lineages, we will use advanced immune assays to determine the effects of radiation dose, dose rate, and fractionation on the survival and phenotype of immune cell lineages from blood, bone marrow, and tumor infiltrating immune cells. We hypothesize that diverse immunologic effects of radiation will have distinct dose-response profiles, such that no single dose of radiotherapy can be defined as “optimal” but rather that a heterogeneous dose of radiation will be best able to activate a potent anti-tumor immune response by optimally engaging distinct mechanisms within a single tumor microenvironment. The insights and treatment regimens developed in these studies should enable more effective clinical translation of therapeutic approaches that combine radiation and immunotherapies in patients with metastatic cancer.
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Administrative-Core-001
  • 批准号:
    10707579
  • 项目类别:
  • 资助金额:
    $7.0万
  • 财政年份:
    2022
  • 负责人:
    Zachary Scott Morris
  • 依托单位:
Molecular Targeted Radionuclide Therapy to Enhance Tumor Cell Susceptibility and Response to Immune Checkpoint Inhibition
  • 批准号:
    10672926
  • 项目类别:
  • 资助金额:
    $38.43万
  • 财政年份:
    2020
  • 负责人:
    Zachary Scott Morris
  • 依托单位:
Molecular Targeted Radionuclide Therapy for Tumor Immunomodulation and Enhancing Immunotherapy Response
  • 批准号:
    10737774
  • 项目类别:
  • 资助金额:
    $7.45万
  • 财政年份:
    2020
  • 负责人:
    Zachary Scott Morris
  • 依托单位:
Administrative-Core-001
  • 批准号:
    10895779
  • 项目类别:
  • 资助金额:
    $7.45万
  • 财政年份:
    2020
  • 负责人:
    Zachary Scott Morris
  • 依托单位:
海外基金