How blood vessel stiffness regulates their growth and maintenance

血管硬度如何调节其生长和维持

• 批准号: DE240101055
• 负责人: Dr Lilian Schimmel
• 金额: $ 31.08万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240101055
• 关键词: How; blood; vessel; stiffness; regulates

This project aims to reveal an unidentified molecular mechanism of how endothelial cells in the walls of blood vessels detect stiffness of the surrounding environment in order to regulate blood vessel growth and maintenance. The results are expected to advance the emerging field of mechanobiology by combining cutting-edge cell biology and microscopy techniques carried out in novel 3D cell culture and unique quail models. The benefits of these outcomes include generation of knowledge on the impact of tissue stiffness on the signalling mechanisms that drive formation and maintenance of blood vessels. In the long term, this fundamental understanding could give rise to major developments in emerging industries such as organ bioengineering.

该项目旨在揭示血管壁中的内皮细胞如何检测周围环境的硬度以调节血管生长和维持的未鉴定分子机制。这些结果有望通过将尖端的细胞生物学和显微镜技术结合在新型3D细胞培养和独特的鹌鹑模型中来推进新兴的机械生物学领域。这些结果的益处包括产生关于组织硬度对驱动血管形成和维持的信号传导机制的影响的知识。从长远来看，这一基本认识可能会导致器官生物工程等新兴产业的重大发展。