Pathology and Biobanking
病理学和生物样本库
基本信息
- 批准号:10460208
- 负责人:
- 金额:$ 48.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-09-19 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AdvocacyBiological AssayBiological MarkersBiological Specimen BanksBreastBreast Cancer PatientCertificationClinicalClinical TrialsCollectionComputer softwareDevelopmentDrug or chemical Tissue DistributionEducationEnsureFundingGenomicsHumanHuman ResourcesImmunofluorescence ImmunologicImmunohistochemistryInformaticsInstitutionLaboratoriesMedicineMicrodissectionMicrofluidicsMolecularPathologyPilot ProjectsPrecision Medicine InitiativePreparationProteomicsReportingResearch PersonnelResource SharingResourcesServicesSpecimenStructureTechniquesTestingTissue MicroarrayTissuesTranslational ResearchValidationWorkanticancer researchassay developmentbasebiobankbiomarker discoverycareer developmentcollegedata warehousedesigndiagnostic platformdigitaldigital imagingexperimental analysisexperimental studyhistological studiesimaging capabilitiesimprovedmalignant breast neoplasmmicroscopic imagingmolecular diagnosticsnext generation sequencingnovelprospectiverepositorystatistics
项目摘要
Abstract
The Pathology and Biobanking Core (PBC) has supported the efforts of the Baylor College of Medicine
Breast SPORE for 26 years, offering comprehensive pathology services to SPORE investigators and others. All
projects in this SPORE application propose the use of human biospecimens in assay development and for
retrospective and/or prospective clinical trials, and this shared resource core is structured to meet the demands
for high-quality, centralized banking and distribution of tissue specimens within this context. We have expertise
and dedicated personnel for all routine histological studies, immunohistochemistry, immunofluorescence, tissue
microarray preparation, and macro/micro-dissection techniques. Additionally, the Core supports advanced
microscopy and digital imaging capability. All projects will also benefit from our recent expansion of state-of-the
art molecular diagnostic platforms and high-complexity assay development, including quantitative PCR,
microfluidics-based digital droplet PCR (ddPCR), next generation sequencing (NGS).
The Core will provide the following services to projects and integration with other cores in this proposal:
1) a centralized resource to acquire, store, and utilize human biospecimens for cancer research; 2) To coordinate
and manage the pathology activities of the SPORE, and ensure that Project Investigators have ready access to
specialized pathology expertise and interpretation; and 3) to design and validate biomarker-based tests (genomic
and/or proteomic) that support all project stages, including clinically-validated and reported assays for SPORE-
based clinical trials.
The SPORE benefits from integrated interactions between components, and this Core will work closely
with other cores, particularly the Informatics and Statistics Core (ISC) for project design and correlative analyses.
Further we will collaborate with the ISC to assist with selection and implementation of biospecimen repository,
tracking and management software that spans all SPORE components. We will work with the Administration
and Advocacy Core in management of laboratory resources and assist Career Development trainees with
education in assay development and experimental analysis. The Core will assist proposed and funded Pilot
Studies with exploratory assay design and technical validation support. The Pathology and Biobanking Core
Laboratory is seeking both CLIA- and CAP-certification to meet Precision Medicine initiatives of this SPORE at
Baylor College of Medicine.
摘要
病理学和生物库核心(PBC)支持贝勒医学院的努力,
乳腺孢子26年,提供全面的病理服务,孢子研究人员和其他人。所有
该SPORE申请中的项目建议在检测开发中使用人类生物样本,
回顾性和/或前瞻性临床试验,并且该共享资源核心的结构满足需求
在这种情况下,组织标本的高质量、集中的储存和分发。We have expertise
以及所有常规组织学研究、免疫组织化学、免疫荧光、组织
微阵列制备和宏观/微观解剖技术。此外,核心支持高级
显微镜和数字成像能力。所有项目也将受益于我们最近扩大的国家,
现有技术的分子诊断平台和高复杂性测定开发,包括定量PCR,
基于微流体的数字液滴PCR(ddPCR)、下一代测序(NGS)。
核心将为项目提供以下服务,并与本建议书中的其他核心集成:
1)一个集中的资源,用于获取、储存和利用人类生物标本进行癌症研究; 2)协调
管理SPORE的病理学活动,并确保项目研究者随时可以访问
专门的病理学专业知识和解释;以及3)设计和验证基于生物标志物的测试(基因组
和/或蛋白质组学),支持所有项目阶段,包括临床验证和报告的孢子检测,
基于临床试验。
SPORE受益于组件之间的集成交互,并且该核心将密切合作
与其他核心,特别是用于项目设计和相关分析的信息学和统计学核心(ISC)。
此外,我们将与ISC合作,协助选择和实施生物标本储存库,
涵盖所有SPORE组件的跟踪和管理软件。我们会与政府合作,
和倡导核心在实验室资源的管理,并协助职业发展学员,
化验发展和实验分析方面的教育。核心小组将协助拟议和资助的试点项目
具有探索性试验设计和技术验证支持的研究。病理学和生物库核心
实验室正在寻求CLIA和CAP认证,以满足该SPORE的精准医学计划,
贝勒医学院。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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George Miles其他文献
George Miles的其他文献
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{{ truncateString('George Miles', 18)}}的其他基金
Rapid Response Monitoring with Circulating Tumor DNA in Metastatic Breast Cancer
转移性乳腺癌中循环肿瘤 DNA 的快速反应监测
- 批准号:
10650926 - 财政年份:2023
- 资助金额:
$ 48.41万 - 项目类别:
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