Mays Cancer Center at UT Health SA

项目摘要--人口科学与预防(PSP)计划 由Pratap Kumar博士和Gail Tomlinson共同领导的人口科学和预防(PSP)计划， 医学博士，有29名成员，代表梅斯癌症中心(MCC)的4所学校和10个系 德克萨斯大学圣安东尼奥分校(UT Health SA)。PSP计划的主要关注点是 针对癌症风险和预防的合作研究，以制定干预策略。研究是 专注于我们的总体目标，即在我们38个县的集水区减少癌症负担。我们的重点是 一直致力于改进癌症筛查和检测，改善获得护理的机会，并预防翻译 通过干预性试验的发现。这些措施包括改善癌症预后的行为干预， 纳入社区外展和服务不足人群的参与。PSP成员有：1) 制定了一组预测前列腺癌复发风险的专利生物标志物；2)确定了 用于对主要发生在年轻的、肥胖的西班牙裔人中的子宫内膜癌亚型进行分层的表观类型； 以及3)表明接触黄曲霉毒素和丙型肝炎病毒可能会导致我们的 集水区和其他拉美裔人口。方案间和方案内的努力发现：1)瑜伽-- 基于运动和营养的干预可以减少循环中的炎症细胞因子，从而增强 乳腺癌患者的存活率；以及2)短信和移动媒体服务帮助西班牙裔青少年/年轻人 成年人(AYA)以具有成本效益的方式戒烟。通过我们的协作工作，我们影响了 我们地理区域(包括农村和边境地区)的人口：例如，识别率提高 那些携带丙型肝炎的人，以及增加HPV疫苗接种、遗传风险评估和检测，以及 加强对遗传高危人群的癌症筛查。在即将到来的癌症中心支持赠款中 (CCSG)周期，我们继续解决整个年龄段不成比例的癌症负担- 儿童、AYA和成人--在我们的集水区。我们计划的具体目标是：1)发现生物标记物 加强早期发现和复发预测；2)将循证化疗/ 干预试验的营养/行为策略；以及3)提高癌症幸存者的生活质量。这些 将通过促进方案内和方案间的合作来实现具体目标，以翻译调查结果 转化为临床干预措施，造福我们的人民。PSP计划成员拥有28笔赠款，总计570万美元(直接 成本)，其中25%(140万美元)来自NCI。在上一个报告所述期间，PSP的多学科调查人员 他们的同行评议出版物增加了一倍多(412篇比186篇)。其中，21%是方案内的，14%是方案内的 项目间合作，77%是多机构合作，53%是与NCI指定的其他癌症中心合作。 此外，在此期间，34%的PSP出版物来自具有影响因子的期刊。 成员在2018年领导了21项临床研究，并将171名患者和332名患者置于干预研究中 关于非干预性研究。PSP成员使用了MCC的所有六个核心设施，特别是生物统计 和生物信息学核心。新招聘的PSP教师正在发起倡议，他们的技能集得到了提升 跨部门翻译工作组和密切合作的方案范围和具体目标 与其他MCC项目和UT Health SA科学界合作。

Project Summary--Population Science and Prevention (PSP) Program The Population Science and Prevention (PSP) Program, co-led by Pratap Kumar, Ph.D. and Gail Tomlinson, M.D., Ph.D., has 29 members, representing 4 schools and 10 departments at the Mays Cancer Center (MCC) at the University of Texas Health San Antonio (UT Health SA). The primary focus of the PSP Program is collaborative research that addresses cancer risk and prevention to develop intervention strategies. Studies are focused on our overarching goal of reducing cancer burden in our 38-county catchment area. Our emphasis has been on improving cancer screening and detection, improving access to care, and translation prevention discoveries through interventional trials. These include behavioral interventions to improve cancer outcomes, incorporating community outreach and engagement of underserved populations. PSP members have: 1) Formulated a panel of patented biomarkers for predicting recurrent risk of prostate cancer; 2) Identified epigenotypes for stratifying an endometrial cancer subtype predominantly occurring in young, obese Hispanics; and 3) Shown that exposure to aflatoxin and hepatitis C virus may cause hepatocellular carcinoma in our catchment area and other Hispanic populations. Inter- and intra-programmatic efforts have found that: 1) Yoga- based exercise and nutritional interventions can reduce circulating inflammatory cytokines, thereby enhancing survival of breast cancer patients; and 2) Texting and mobile media services help Hispanic adolescent/young adults (AYAs) quit smoking in a cost-effective manner. Through our collaborative work, we have impacted the population across our geographic area (including rural and border regions): e.g. increased identification rates of those carrying hepatitis C, and increased HPV vaccine administration, genetic risk assessment and testing, and enhanced cancer screening in genetically at-risk populations. In the upcoming Cancer Center Support Grant (CCSG) cycle, we continue to address the disproportionate burden of cancer across the age continuum – children, AYAs, and adults – in our catchment area. Our Program’s Specific Aims are to: 1) Discover biomarkers to enhance early detection and recurrent prediction; 2) Translate evidence-based chemotherapeutic/ nutritional/behavioral strategies to interventional trials; and 3) Enhance quality of life for cancer survivors. These Specific Aims will be achieved by promoting intra- and inter-programmatic collaborations to translate findings into clinical interventions to benefit our population. PSP Program members hold 28 grants totaling $5.7M (direct costs), with 25% ($1.4M) from the NCI. Over the last reporting period, the PSP’s multidisciplinary investigators more than doubled their peer-reviewed publications (412 vs. 186). Of these, 21% are intra-programmatic, 14% inter-programmatic, 77% multi-institutional collaborations, and 53% with other NCI-designated Cancer Centers. In addition, 34% of PSP publications during this period were from journals with an impact factor >5. PSP members led 21 clinical research studies during 2018 and placed 171 patients on interventional studies and 332 on non-interventional studies. PSP members have used all six MCC core facilities, especially the Biostatistics and Bioinformatics Core. Initiatives are being generated by newly recruited PSP faculty whose skill sets enhance the Program scope and Specific Aims by cross-cutting translational working groups, and by close collaborations with the other MCC Programs and the UT Health SA scientific community.