ESTABLISHMENT OF A FAMILIAL BREAST CANCER REGISTRY

描述（申请人的描述编辑）的达拉斯县家庭 UT西南医学中心的乳腺癌登记处将 包括基于人群的临床数据储存库， 人口统计学和谱系信息以及生物标本 从乳腺癌家庭和适当的对照中获得。 存放在这个储存库的生物样本将包括 血清，提取DNA，淋巴母细胞系，冻存 单核细胞，石蜡块标本，在某些情况下， 新鲜肿瘤和正常组织材料。注册表的设计 促进合作， 表征易患乳腺癌的新基因。 这项申请的资助将促进遗传相关性 易感因素与人口统计学和生殖风险因素。 注册表扩展了现有的UT西南 家族性癌症登记，UT西南医学的共同努力 中心;德克萨斯州肿瘤学，宾夕法尼亚州，一个大型的肿瘤学私人实践网络 贝勒大学医学坎特，一家大型私立医院; 和苏珊·G科门乳腺癌基金会。 这种独特 一个被称为“科门联盟”的伙伴关系迄今已确定 分析了300多个可能有乳腺癌倾向的家庭， 癌要研究的人口基数将与达拉斯相对应 县，得克萨斯州，人口200万，其中包括约 每年新增1080例乳腺癌。 我们将尝试 筛查达拉斯县每一个新诊断的乳腺癌病例 并将大力鼓励下列各方参与： 女性乳腺癌的家族性表现 乳腺癌登记。

DESCRIPTION (Applicant's Description-edited) The Dallas County Familial Breast Cancer Registry at UT Southwestern Medical Center will comprise a population-based repository of clinical data, demographic and pedigree information as well as biological specimens obtained from breast cancer families and appropriate controls. The biological specimens to be stored in this repository will include serum, extracted DNA, lymphoblastoid cell lines, cryopreserved mononuclear cells, paraffin block specimens and, in some instances, fresh tumor and normal tissue materials. The registry is designed to facilitate collaboration involving the identification and characterization of new genes which predispose to breast cancer. Funding of this application will facilitate correlation of genetic predisposition factors with demographic and reproductive risk factors. The registry extends the already existing UT Southwestern Familial Cancer Registry, a joint effort of UT Southwestern Medical Center; Texas Oncology, PA, a large private practice network of oncology specialist; Baylor University Medical Canter, a large private hospital; and the Susan G. Komen Breast Cancer Foundation. This unique partnership, known as "The Komen Alliance" has to date identified and analyzed over 300 families with a probable predisposition to breast cancer. The population base to be studied will correspond to Dallas County, Texas, a population of 2 million which includes approximately 1080 new cases of breast cancer annually. We will attempt to screen every newly diagnosed case of breast cancer in Dallas County over a two-year period and will strongly encourage participation by women thought to have a familial form of breast cancer in the Familial Breast Cancer Registry.