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Neuroimaging Core

神经影像核心

基本信息

批准号：
10461090
负责人：
JOHN A DETRE
金额：
$ 70.91万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10461090
关键词：
Aging Alzheimer&apos s Disease Alzheimer&apos s disease pathology Alzheimer&apos s disease related dementia Amyloid Amyloid beta-Protein Angiography Autopsy Biological Biological Markers Blood Vessels Brain Brain imaging Cerebral hemisphere Clinical Clinical Research Collaborations Consensus Data Data Provenance Databases Development Dimensions Disease Disease Progression Doctor of Medicine Doctor of Philosophy Evaluation Functional Imaging Genetic Genomics Heterogeneity Histopathology Image Image Analysis Incidence Infrastructure Intervention Light Link MRI Scans Magnetic Resonance Imaging Measures Metadata Methods Modality Molecular Monitor Nerve Degeneration Neurodegenerative Disorders Optical Coherence Tomography Participant Pathology Phenotype Plasma Positron-Emission Tomography Procedures Process Protocols documentation Reproducibility Research Research Infrastructure Research Personnel Research Subjects Resources Retina Risk Sampling Scanning Scientist Slide Specificity Staging Structure Tissues Tracer Training and Education Translations Universities Update Validation Washington base biomarker development brain behavior brain magnetic resonance imaging brain tissue clinical center cohort data infrastructure data integration data management data sharing digital digital pathology education research flexibility image guided imaging informatics imaging study in vivo informatics infrastructure insight ischemic lesion method development molecular imaging morphometry multimodality neuroimaging neuroimaging marker neuroinflammation neuropathology neurovascular novel outreach perfusion imaging pre-clinical radioligand recruit retinal imaging statistics tau Proteins

项目摘要

Neuroimaging Core Project Summary Because of their tolerability, versatility, and spatial specificity, neuroimaging biomarkers are a prominent strategy used in AD/ADRD research to detect AD pathology, provide insights into disease mechanism and heterogeneity, track disease progression and, ultimately, monitor the efficacy of disease-modifying interventions. Neuroimaging methods can also noninvasively assess other neuropathophysiological mechanisms such as neurovascular insufficiency and neuroinflammation that are implicated as mechanisms and modulators of AD and therefore likely contribute to the heterogeneity observed in its risk, incidence, and progression. When linked to postmortem measures of proteinopathy burden, imaging measures can shed light on heterogeneity of AD/ADRD, allowing for discovery of in vivo signatures of “pure AD” and concomitant non- AD pathologies. The Penn ADRC Neuroimaging Core will consolidate expertise in advanced neuroimaging methods and applications to support the acquisition and analysis of state-of-the-art multimodal MRI of brain structure and function, molecular brain imaging using PET, retinal angiography using optical coherence tomography (OCTA). The Neuroimaging Core will oversee the acquisition and analysis of standard MRI and PET scans used in defining preclinical AD based on amyloid, tau, and neurodegeneration (“A/T/(N)”) staging and for quantifying ischemic lesions in the brain. Additional unique features of the Neuroimaging Core include the use of ultra- high-field (7T) MRI both in vivo and for post-mortem imaging of intact hemispheres, the development methods for accurate image-guided sampling of post-mortem brain tissue allowing spatial linkage between digital pathology and in vivo morphometry, the development a data infrastructure linking imaging and non-imaging databases, novel MRI and OCT methods for quantifying brain structure and vascular function in ADRC research, and infrastructure to support the translation of novel PET tracers to clinical research in AD/ADRD. The Neuroimaging Core will also share imaging data collected at the Penn ADRC with the NACC Coordinating Center at the University of Washington and SCAN U24. The Neuroimaging Core will be highly integrated with other ADRC cores, providing access to advanced imaging and derived imaging metrics for the Clinical Core, collaboration on image analysis and databasing of image-based information with the Data Management and Statistics Core, linking in vivo and postmortem neuroimaging to neuropathology in conjunction with the Neuropathology Core, leveraging imaging as a means of linking genetic factors with structural and functional brain phenotype with Genomics Core, working with the Outreach Recruitment and Engagement Core to provide research updates about neuroimaging advances and promote participation in imaging studies, and providing education and training in neuroimaging through Research Education Component.

神经影像学核心项目总结