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Neurobiology of avoidant/restrictive eating in youth

青少年回避/限制性饮食的神经生物学

基本信息

批准号：
10460510
负责人：
Elizabeth Austen Lawson
金额：
$ 19.22万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10460510
关键词：
Acute Amygdaloid structure Appetite Stimulants Arousal Award Behavioral Biological Markers Brain Brain imaging Brain-Derived Neurotrophic Factor Categories Cell Nucleus Choking Cholecystokinin Clinical Clinical Investigator Clinical Research Consumption Desire for food Dimensions Discipline Doctor of Medicine Eating Eating Behavior Eating Disorders Endocrine Endocrinology Environment Faculty Food Foundations Fright Functional disorder Funding Future Galvanic Skin Response General Hospitals Goals Grant Healthcare Heart Rate Homeostasis Hormones Human Hydrocortisone Hypothalamic structure Image Institution Insula of Reil Leadership Link Literature Magnetic Resonance Imaging Massachusetts Medial Medicine Mentors Methods Mid-Career Clinical Scientist Award (K24)Mission Modeling Multimodal Imaging National Institute of Mental Health Negative Valence Neurobiology Oxytocin Pathway interactions Peer Review Grants Perception Phenotype Psychiatry Psychology Publications Research Research Domain Criteria Research Personnel Research Project Grants Research Support Resistance Resources Sensory Structure Taste Perception Techniques Thalamic structure Time Training United States National Institutes of Health Vomiting Weight Work Youth base behavioral outcome biophysical properties brain abnormalities career cognitive system experience ghrelin gray matter hormonal signals imaging biomarker innovation median forebrain bundle medical schools mid-career faculty multidisciplinary multimodal neuroimaging multimodality neurobiological mechanism neuroimaging novel patient oriented research programs psychologic response restrictive eating stria terminalis three-dimensional modeling training opportunity trait white matter

项目摘要

Project Summary/Abstract The applicant, Elizabeth A. Lawson, M.D., M.M.Sc., is a practicing neuroendocrinologist at Massachusetts General Hospital and Associate Professor of Medicine at Harvard Medical School. Over the last decade Dr. Lawson’s research has focused on the link between hormone signaling, brain functioning, psychology and eating behavior in humans across a spectrum of weights and eating disorders. Her successful mentoring experience, publication and funding record demonstrate her commitment and passion for patient-oriented research and provide an excellent foundation to accomplish the goals and objectives of the K24 Award. The specific aims are: 1) To enable Dr. Lawson to dedicate time to mentor junior clinical investigators based on her already NIH funded R01 grant on neurobiological underpinnings of avoidant/restrictive eating; 2) To mentor residents, fellows, and junior faculty from Psychiatry, Endocrinology, and other fields at MGH and across institutions with the goal of developing them into clinical investigators who can successfully compete for peer- reviewed grants related to the NIMH mission; and 3) To enable Dr. Lawson to further establish a patient- oriented research program that uses innovative multidisciplinary techniques to investigate the neurobiology underlying eating behaviors, and that provides an ideal environment to develop future leaders in clinical research. The training environment is outstanding in terms of didactic resources and availability of techniques to assess cross-disciplinary endpoints. Importantly, Dr. Lawson has the strong commitment from leadership of both Endocrinology and Psychiatry who have enthusiastically endorsed her research program, mentoring, and K24 proposal. The specific research aims of the application are based on a recently funded R01 investigating the link between hormones, brain function and clinical features in youth with avoidant/restrictive eating. Important new directions will include multimodal neuroimaging, including assessment of brain structure (gray matter volume and white matter connectivity) and relationship with functional brain abnormalities and clinical features.

项目总结/文摘