Neural Network Dynamics Over the Course of Aversive Conditioning: The Influence of Visuocortical and Attentional Network Activity in Predicting Extinction Learning

厌恶条件作用过程中的神经网络动力学：视觉皮层和注意网络活动对预测灭绝学习的影响

• 批准号: 10463102
• 负责人: Richard Tyler Ward
• 金额: $ 6.68万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10463102
• 关键词: Affect; Amygdaloid structure; Anxiety; Anxiety Disorders; Attention; Behavior; Behavioral; Brain; Clinical; Clinical Treatment; Clinical assessments; Communication; Complement; Complex; Computer Models; Cues; Data; Diagnostic; Electroencephalography; Electrophysiology (science); Etiology; Extinction (Psychology); Feedback; Fellowship; Female; Fright; Functional Magnetic Resonance Imaging; Goals; Grant; Impairment; Individual; Individual Differences; Intervention; Knowledge; Laboratories; Learning; Literature; Magnetic Resonance; Measures; Mental Health; Modeling; National Institute of Mental Health; Neuraxis; Outcome; Participant; Perception; Phenotype; Physiological; Procedures; Process; Psychophysics; Regimen; Research; Research Domain Criteria; Research Training; Resistance; Role; Sex Differences; Shapes; Structure; Techniques; Testing; Theoretical model; Time; Training; Visual; Visual Perception; Visual attention; Woman; Work; advanced analytics; anxiety treatment; attentional bias; aversive conditioning; biological sex; conditioned fear; conditioning; experience; hemodynamics; improved; learning extinction; neural network; neuroimaging; neuromechanism; neurophysiology; neuroregulation; novel; potential biomarker; relating to nervous system; response; sex; skills; tool; trait; treatment of anxiety disorders

PROJECT SUMMARY/ABSTRACT Visual cues predicting aversive outcomes facilitate low-level visual perception—often referred to as attentional threat biases—and heighten defensive engagement at the behavioral, autonomic, and central nervous system levels. However, as aversive conditioning proceeds over time, psychophysics and neuroimaging work has found threat biases accompanied by reduced, instead of heightened, activity of the brain's defensive network. Additional literature indicates that aversive conditioning is facilitated in females and individuals with greater dispositional anxiety, implicating a critical role of biological sex and individual differences in trait-like anxiety phenotypes. How these differences affect the acquisition and extinction of attentional threat biases is currently unknown. Such knowledge is critical to identifying novel neural etiological and intervention targets for clinical tools. The present training grant aims to establish the neural dynamics during visual threat bias acquisition and extinction. Specifically, we test the overarching hypothesis that temporally extended aversive conditioning increasingly relies on biased perception and attention, and less on defensive brain circuits including the amygdala. This work will contribute to NIMH strategic priorities by defining the underlying neural mechanisms contributing to complex behaviors. Thus, the proposed project aims to first (1) identify progressive changes in visual, attentional, and limbic neural networks contributing to the representation of threat versus safe-related visual cues over the course of acquisition by measuring trial-by-trial electrophysiological and hemodynamic activity. Second, (2) determine the value of individual differences in visual and attentional frontoparietal network changes during threat cue acquisition for predicting extinction and extinction recall. Third, (3) examine the extent to which individual differences in biological sex and dispositional anxiety influence changes in cortical representations of threat cues during acquisition and subsequent extinction. Participants will engage in a 2-day aversive conditioning regimen in which they undergo differential aversive conditioning followed by an extinction paradigm, and return on day 2 for a reinstatement test. Simultaneous electroencephalography (EEG) and functional magnetic resonance (fMRI) imaging during these tasks will enable the identification of functional brain alterations, fulfilling the aims of the proposed research. Pursuing these aims will aid in current efforts in improving diagnostic assessment and treatment for anxiety disorders. The training goals of this fellowship will develop the applicant's knowledge and research skills regarding theoretical components related to differential aversive conditioning, EEG-fMRI acquisition, and advanced neuroimaging analytical techniques. This project is the first to examine cortical network changes over the course of aversive conditioning, the influence these dynamics have on extinction, and how individual differences moderate these effects.

项目摘要/摘要 预测厌恶结果的视觉提示促进了低水平的视觉感知--通常被称为 注意威胁偏向-并提高行为、自主和中枢的防御参与度 神经系统水平。然而，随着厌恶条件作用的发展，心理物理学和神经成像 研究发现，威胁偏见伴随着大脑防御活动的减少而不是增强 网络。其他文献表明，厌恶条件反射在女性和患有 更大的倾向性焦虑，暗示了生物性别和个体差异在特质样中的关键作用 焦虑表型。这些差异是如何影响注意威胁偏向的获得和消退的 目前尚不清楚。这些知识对于确定新的神经病因和干预靶点是至关重要的 临床工具。目前的培训经费旨在建立视觉威胁偏向习得过程中的神经动力学 和灭绝。具体地说，我们测试了时间延长的厌恶条件反射的主要假设 越来越多地依赖于有偏见的感知和注意力，而较少依赖防御性大脑回路，包括 杏仁核。这项工作将通过定义潜在的神经机制来促进NIMH的战略优先事项 导致了复杂的行为。因此，拟议的项目旨在首先(1)确定以下方面的渐进性变化 视觉、注意和边缘神经网络有助于表示威胁与安全相关 通过一次又一次的电生理和血流动力学测量获得过程中的视觉提示 活动。第二，(2)确定视觉和注意额顶网络中个体差异的价值 用于预测灭绝和灭绝回忆的威胁线索获取过程中的变化。第三，(3)审查程度 生物性别和性格焦虑的个体差异对大脑皮层变化的影响 在获取和随后的灭绝过程中呈现威胁线索。参与者将参与为期2天的 厌恶性条件反射，其中它们经历不同的厌恶性条件反射，然后消退 范型，并在第二天返回进行恢复测试。同步脑电(EEG)和 在这些任务中的功能磁共振(FMRI)成像将使识别功能大脑成为可能 改建，实现拟议研究的目标。追求这些目标将有助于当前改进 焦虑症的诊断评估和治疗。该奖学金的培训目标将发展 应聘者对与差分厌恶相关的理论成分的知识和研究技能 条件反射、脑电-功能磁共振成像采集和先进的神经成像分析技术。这个项目是第一个 为了检查厌恶条件反射过程中皮质网络的变化，这些动力学的影响 以及个体差异如何缓和这些影响。

项目成果

State anxiety reduces working memory capacity but does not impact filtering cost for neutral distracters.

• DOI: 10.1111/psyp.13625
• 发表时间: 2020-10
• 期刊: PSYCHOPHYSIOLOGY
• 影响因子: 3.7
• 作者: Ward, Richard T.;Lotfi, Salahadin;Sallmann, Hannah;Lee, Han-Joo;Larson, Christine L.
• 通讯作者: Larson, Christine L.

Working Memory Performance for Differentially Conditioned Stimuli.

• DOI: 10.3389/fpsyg.2021.811233
• 发表时间: 2021
• 期刊: Frontiers in psychology
• 影响因子: 3.8
• 作者: Ward RT;Lotfi S;Stout DM;Mattson S;Lee HJ;Larson CL
• 通讯作者: Larson CL

The Relationship Between Self-Reported Misophonia Symptoms and Auditory Aversive Generalization Leaning: A Preliminary Report.

• DOI: 10.3389/fnins.2022.899476
• 发表时间: 2022
• 期刊: FRONTIERS IN NEUROSCIENCE
• 影响因子: 4.3
• 作者: Ward, Richard T.;Gilbert, Faith E.;Pouliot, Jourdan;Chiasson, Payton;McIlvanie, Skylar;Traiser, Caitlin;Riels, Kierstin;Mears, Ryan;Keil, Andreas
• 通讯作者: Keil, Andreas

Neutral and threatening distracter word stimuli are unnecessarily stored in working memory but do not differ in their degree of working memory storage.

• DOI: 10.1016/j.biopsycho.2021.108091
• 发表时间: 2021-05
• 期刊: BIOLOGICAL PSYCHOLOGY
• 影响因子: 2.6
• 作者: Ward, Richard T.;Lotfi, Salahadin;Stout, Daniel M.;Mattson, Sofia;Lee, Han-Joo;Larson, Christine L.
• 通讯作者: Larson, Christine L.

Reward-related distracters and working memory filtering.

与奖励相关的干扰因素和工作记忆过滤。

• DOI: 10.1111/psyp.13402
• 发表时间: 2019
• 期刊: Psychophysiology
• 影响因子: 3.7
• 作者: Ward,RichardT;Miskovich,TaraA;Stout,DanielM;Bennett,KennethP;Lotfi,Salahadin;Larson,ChristineL
• 通讯作者: Larson,ChristineL