Sex-based Muscular Adaptations, Capillary dysfunction and functional decline impact Knee-related psychosocial outcomes after acute knee injury (SMACK)

基于性别的肌肉适应、毛细血管功能障碍和功能下降影响急性膝关节损伤后膝关节相关的心理社会结果 (SMACK)

基本信息

  • 批准号:
    10462626
  • 负责人:
  • 金额:
    $ 62.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-08-05 至 2027-05-31
  • 项目状态:
    未结题

项目摘要

Abstract Following an Anterior Cruciate Ligament (ACL) reconstruction, females have worse outcomes; however, skeletal muscle biology and function have preferentially been studied in males. These observations suggest that there are sex-based differences in the biological mechanisms contributing to recovery of muscle function. Intriguing pilot data in this proposal show preferential impairment in the recovery of quadriceps muscle and function and diminished psychosocial recovery in females as compared to males following ACL reconstruction. This proposal seeks to test the novel hypothesis that following an ACL injury, females experience exaggerated muscle cellular and molecular deficits, hindering their recovery of strength, resulting in pronounced deficiencies in gait mechanics and disproportionally worse psychosocial recovery compared to males. By identifying the cellular and molecular foundation of sex-based differences, subsequent clinical trials can test sex specific approaches to improve outcomes for women after ACL injury. We will in Aim 1 define the molecular, cellular and morphological sex-based differences in quadriceps muscle after ACL injury and reconstruction. In Aim 2 determine the effect of sex on knee function after an ACL reconstruction. Lastly, in Aim 3 will determine the timing and magnitude of psychosocial recovery differences between females and males following an ACL reconstruction. Results from this work will exert an immediate impact on clinical practice guidelines, as well as identify critical therapeutic targets needed to propel subsequent evidence-based clinical trials designed to improve rehabilitative outcomes for females.
摘要

项目成果

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Christopher Fry其他文献

Christopher Fry的其他文献

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{{ truncateString('Christopher Fry', 18)}}的其他基金

Sex-based Muscular Adaptations, Capillary dysfunction and functional decline impact Knee-related psychosocial outcomes after acute knee injury (SMACK)
基于性别的肌肉适应、毛细血管功能障碍和功能下降影响急性膝关节损伤后膝关节相关的心理社会结果 (SMACK)
  • 批准号:
    10295304
  • 财政年份:
    2021
  • 资助金额:
    $ 62.78万
  • 项目类别:
Myostatin Alters Muscle Composition as The Result of an ACL Injury
ACL 损伤导致肌肉生长抑制素改变肌肉成分
  • 批准号:
    10380581
  • 财政年份:
    2018
  • 资助金额:
    $ 62.78万
  • 项目类别:
Myostatin Alters Muscle Composition as The Result of an ACL Injury
ACL 损伤导致肌肉生长抑制素改变肌肉成分
  • 批准号:
    10017391
  • 财政年份:
    2018
  • 资助金额:
    $ 62.78万
  • 项目类别:
Regulation of skeletal muscle extracellular matrix remodeling by satellite cells
卫星细胞对骨骼肌细胞外基质重塑的调节
  • 批准号:
    8716845
  • 财政年份:
    2014
  • 资助金额:
    $ 62.78万
  • 项目类别:

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