Novel time-efficient inspiratory muscle strength training for lowering systolic blood pressure and improving endothelial, cerebrovascular, and cognitive function

项目总结 候选人：丹尼尔·H·克雷格海德，博士，博士后，在华盛顿大学接受综合生理学培训 科罗拉多大学博尔德分校。在这项K01应用中，Craighead博士的目标是确定 高阻力吸气肌力训练(IMST)，一种新的、省时的生活方式干预，用于 降低收缩压(SBP)，改善内皮、脑血管和认知功能。他的 眼前的目标是获得过渡到 独立的，外部资助的调查员。他的长期目标是建立自己的研究计划 重点是确定新的、以证据为基础的生活方式干预措施，降低血压和预防 或者延缓与血压相关的合并症和慢性病的发展。职业生涯 发展计划：克雷格黑德博士的职业发展计划包括：1)获得新技能 评估脑血管和认知功能，以支持他提出的研究计划；2)训练新细胞 以及评估氧化应激和一氧化氮变化的分子技术--生物利用度；3) 通过课程工作发展专业技能；参加哥伦比亚大学周刊俱乐部的演讲/演讲 研讨会和国家科学会议；以及与他的导师团队的定期互动。环境： 克雷格黑德博士的培训计划的环境将非常出色。克雷格黑德博士的主要导师。 Douglas Seals和共同导师Michel Chonchol博士是国际公认的NIH资助的科学家 在转化性生物医学研究中成功指导的良好记录。共同导师菲奥娜·贝利博士 在高阻IMST上进行了开创性的工作，使她成为这种新颖生活方式的首屈一指的专家 干预。咨询导师尤志英博士是该校医学系高级生物统计师 CU Anschutz医学院，并定期为学员和教职员工提供指导/咨询 临床试验。咨询导师菲利普·安斯利博士是加拿大脑血管生理学研究主席 有丰富的脑血管功能评估经验。咨询导师Brianne Bettcher博士是 加州大学安舒茨分校医学院助理教授，认知功能评估专家。 研究：SBP高于正常是一种非常普遍的疾病，困扰着大多数50岁以上的成年人。 SBP高于正常水平会增加患心血管疾病、中风、认知能力下降和 其他慢性病。这种风险的增加很大程度上归因于血管功能障碍的发展。 在外周和脑动脉，继发于氧化应激增加和随之而来的减少 在一氧化氮中-生物利用度。健康的生活方式是降低SBP和降低血压的一线疗法 疾病风险；然而，由于这些做法的时间密集性，遵守这些做法的情况很差。建议数 研究将测试高效、高阻力的IMST在促进依从性、降低SBP、 改善SBP高于正常的成年人的内皮、脑血管和认知功能。

PROJECT SUMMARY CANDIDATE: Daniel H. Craighead, PhD, is a postdoctoral fellow training in integrative physiology at the University of Colorado (CU) Boulder. In this K01 application, Dr. Craighead aims to determine the efficacy of high-resistance inspiratory muscle strength training (IMST), a novel and time-efficient lifestyle intervention, for lowering systolic blood pressure (SBP) and improving endothelial, cerebrovascular, and cognitive function. His immediate goal is to acquire the research training and professional skills necessary to transition to an independent, extramurally funded investigator. His long-term goal is to establish his own research program with a focus on identifying novel, evidence-based lifestyle interventions that lower blood pressure and prevent or delay the development of blood pressure-associated comorbidities and chronic diseases. CAREER DEVELOPMENT PLAN: Dr. Craighead's career development plan consists of: 1) acquiring new skills to assess cerebrovascular and cognitive function to support his proposed research plan; 2) train in new cellular and molecular techniques to assess changes in oxidative stress and nitric oxide-bioavailability; and 3) professional skill development through coursework; attendance/presentations at weekly journal clubs, CU seminars, and national scientific meetings; and regular interactions with his mentor team. ENVIRONMENT: The environment for Dr. Craighead's training plan will be outstanding. Dr. Craighead's primary mentor, Dr. Douglas Seals, and co-mentor, Dr. Michel Chonchol, are internationally recognized, NIH-funded scientists with strong records of successful mentoring in translational biomedical research. Co-mentor, Dr. Fiona Bailey, performed the pioneering work on high-resistance IMST, making her the foremost expert of this novel lifestyle intervention. Consulting mentor Dr. Zhiying You is Senior Biostatistician in the Department of Medicine at the CU Anschutz Medical Campus and regularly provides mentoring/consulting to trainees and faculty conducting clinical trials. Consulting mentor Dr. Philip Ainslie is the Canada Research Chair in Cerebrovascular Physiology with extensive experience assessing cerebrovascular function. Consulting mentor Dr. Brianne Bettcher is an Assistant Professor at the CU Anschutz Medical Campus and expert in assessing cognitive function. RESEARCH: Above-normal SBP is a highly prevalent condition, afflicting the majority of adults over age 50. Above-normal SBP increases the risk for developing cardiovascular diseases, stroke, cognitive decline, and other chronic conditions. This increased risk is largely attributable to the development of vascular dysfunction in the peripheral and cerebral arteries, secondary to an increase in oxidative stress and consequent reduction in nitric oxide-bioavailability. Healthy lifestyle practices are first-line therapies to lower SBP and decrease disease risk; however, adherence to these practices is poor due to their time-intensive nature. The proposed research will test the efficacy of time-efficient, high-resistance IMST for promoting adherence, lowering SBP, and improving endothelial, cerebrovascular, and cognitive function in adults with above-normal SBP.