Novel time-efficient inspiratory muscle strength training for lowering systolic blood pressure and improving endothelial, cerebrovascular, and cognitive function

新颖、省时的吸气肌力量训练，可降低收缩压并改善内皮、脑血管和认知功能

• 批准号: 10223434
• 负责人: Daniel Harrison Craighead
• 金额: $ 17.97万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10223434
• 关键词: Acute; Adherence; Adult; Aerobic Exercise; Age; Ascorbic Acid; Biological Availability; Biomedical Research; Biopsy; Blood Flow Velocity; Blood Pressure; Blood Vessels; Canada; Cardiovascular Diseases; Cardiovascular Physiology; Cerebrovascular Disorders; Cerebrovascular Physiology; Chronic; Chronic Disease; Clinical; Clinical Trials; Cognitive; Colorado; Conduct Clinical Trials; Consult; Data; Dementia; Development; Development Plans; Diastolic blood pressure; Doctor of Philosophy; Double-Blind Method; Dropout; Endothelial Cells; Endothelium; Environment; Epidemic; Extramural Activities; Faculty; Functional disorder; Funding; Goals; Guidelines; Hour; Hypercapnia; Hypertension; Impaired cognition; Infusion procedures; Inhalation; Internal carotid artery structure; International; Intervention; Journals; Link; Mediating; Medical; Medicine; Mentors; Molecular; Nature; Nitric Oxide; Obstructive Sleep Apnea; Oxidative Stress; Patients; Peripheral; Physiologic pulse; Physiological; Physiology; Population; Postdoctoral Fellow; Process; Production; Proteins; Protocols documentation; Randomized Clinical Trials; Records; Research; Research Personnel; Research Priority; Research Project Grants; Research Training; Resistance; Rest; Risk; Scientist; Secondary to; Serum; Signaling Molecule; Sodium-Restricted Diet; Stroke; Superoxides; Techniques; Time; Training; United States; United States National Institutes of Health; Universities; Vascular Diseases; Vascular Endothelium; Woman; Work; aged; arterial stiffness; base; blood pressure reduction; brachial artery; cardiovascular disorder risk; cardiovascular risk factor; career development; cerebral artery; cerebrovascular; clinically relevant; cognitive enhancement; cognitive function; cognitive performance; comorbidity; disorder risk; efficacy evaluation; efficacy testing; endothelial dysfunction; evidence base; experience; healthy lifestyle; improved; innovation; lifestyle intervention; meetings; men; middle cerebral artery; modifiable risk; muscle strength; novel; pilot trial; pressure; prevent; professor; programs; response; seal; skill acquisition; skills; strength training; therapy development; treatment duration

PROJECT SUMMARY CANDIDATE: Daniel H. Craighead, PhD, is a postdoctoral fellow training in integrative physiology at the University of Colorado (CU) Boulder. In this K01 application, Dr. Craighead aims to determine the efficacy of high-resistance inspiratory muscle strength training (IMST), a novel and time-efficient lifestyle intervention, for lowering systolic blood pressure (SBP) and improving endothelial, cerebrovascular, and cognitive function. His immediate goal is to acquire the research training and professional skills necessary to transition to an independent, extramurally funded investigator. His long-term goal is to establish his own research program with a focus on identifying novel, evidence-based lifestyle interventions that lower blood pressure and prevent or delay the development of blood pressure-associated comorbidities and chronic diseases. CAREER DEVELOPMENT PLAN: Dr. Craighead's career development plan consists of: 1) acquiring new skills to assess cerebrovascular and cognitive function to support his proposed research plan; 2) train in new cellular and molecular techniques to assess changes in oxidative stress and nitric oxide-bioavailability; and 3) professional skill development through coursework; attendance/presentations at weekly journal clubs, CU seminars, and national scientific meetings; and regular interactions with his mentor team. ENVIRONMENT: The environment for Dr. Craighead's training plan will be outstanding. Dr. Craighead's primary mentor, Dr. Douglas Seals, and co-mentor, Dr. Michel Chonchol, are internationally recognized, NIH-funded scientists with strong records of successful mentoring in translational biomedical research. Co-mentor, Dr. Fiona Bailey, performed the pioneering work on high-resistance IMST, making her the foremost expert of this novel lifestyle intervention. Consulting mentor Dr. Zhiying You is Senior Biostatistician in the Department of Medicine at the CU Anschutz Medical Campus and regularly provides mentoring/consulting to trainees and faculty conducting clinical trials. Consulting mentor Dr. Philip Ainslie is the Canada Research Chair in Cerebrovascular Physiology with extensive experience assessing cerebrovascular function. Consulting mentor Dr. Brianne Bettcher is an Assistant Professor at the CU Anschutz Medical Campus and expert in assessing cognitive function. RESEARCH: Above-normal SBP is a highly prevalent condition, afflicting the majority of adults over age 50. Above-normal SBP increases the risk for developing cardiovascular diseases, stroke, cognitive decline, and other chronic conditions. This increased risk is largely attributable to the development of vascular dysfunction in the peripheral and cerebral arteries, secondary to an increase in oxidative stress and consequent reduction in nitric oxide-bioavailability. Healthy lifestyle practices are first-line therapies to lower SBP and decrease disease risk; however, adherence to these practices is poor due to their time-intensive nature. The proposed research will test the efficacy of time-efficient, high-resistance IMST for promoting adherence, lowering SBP, and improving endothelial, cerebrovascular, and cognitive function in adults with above-normal SBP.

项目摘要 候选人：丹尼尔H。Craighead博士，是一名博士后研究员，在综合生理学方面接受培训， 科罗拉多大学博尔德分校。在K 01申请中，Craighead博士的目的是确定 高阻力吸气肌肉力量训练（IMST），一种新颖的，时间效率高的生活方式干预， 降低收缩压（SBP），改善内皮、脑血管和认知功能。他 近期目标是获得必要的研究培训和专业技能，以过渡到一个 独立的，由校外资助的调查员他的长期目标是建立自己的研究计划 重点是确定新的、以证据为基础的生活方式干预措施， 或延迟血压相关的合并症和慢性疾病的发展。职业生涯 Craighead的职业发展计划包括：1）获得新技能， 评估脑血管和认知功能，以支持他提出的研究计划; 2）培训新的细胞 和分子技术，以评估氧化应激和一氧化氮生物利用度的变化;以及3） 通过课程学习发展专业技能;出席每周期刊俱乐部/演讲，CU 研讨会和国家科学会议;以及与他的导师团队的定期互动。环境： 克雷格黑德博士的训练环境会很棒克雷格黑德博士的主要导师，博士。 道格拉斯海豹，和共同导师，博士米歇尔Chonchol，是国际公认的，NIH资助的科学家， 在转化生物医学研究方面有良好的成功指导记录。共同导师菲奥娜·贝利医生 在高阻力IMST上进行了开创性的工作，使她成为这种新颖生活方式的最重要专家 干预咨询导师Zhiying You博士是美国加州大学医学院医学系的高级生物统计学家， CU Anschutz医学院，并定期提供指导/咨询，以学员和教师进行 临床试验咨询导师Philip Ainslie博士是加拿大脑血管生理学研究主席 有丰富的评估脑血管功能的经验咨询导师Brianne Bettcher博士是一位 CU Anschutz医学院助理教授，认知功能评估专家。 研究：SBP异常是一种非常普遍的疾病，困扰着大多数50岁以上的成年人。 血压正常的人患心血管疾病、中风、认知能力下降的风险增加， 其他慢性病。这种增加的风险主要归因于血管功能障碍的发展 在外周动脉和脑动脉中，继发于氧化应激的增加和随之而来的减少 一氧化氮的生物利用度健康的生活方式实践是降低SBP和降低 疾病风险;然而，由于这些做法时间密集，遵守这些做法的情况很差。拟议 研究将测试时间效率高、阻力大的IMST在促进依从性、降低SBP 并改善SBP高于正常值的成人的内皮、脑血管和认知功能。