2022 Lysosomes & Endocytosis Gordon Research Conference and Gordon Research Seminar

摘要 本申请要求对关于溶酶体的戈登研究会议（GRC）提供部分支持， 2022年6月19日至24日在新罕布什尔州安多弗的普罗克特学院进行内吞。支持相关的戈登 研究研讨会（GRS）之前的GRC（6月18日至19日）也被要求。溶酶体 和内吞GRC有50多年的传统，作为研究人员的卓越科学场所， 内吞作用和溶酶体生物学。它也被高度评价为高水平的 在所有职业层次的同事之间的沟通，并为初级同事的指导。有关详细 十多年来，内吞作用的分子机制以及将分子靶向溶酶体， 退化是本次GRC的重点。然而，该领域发展迅速，最近的进展表明， 内溶酶体和自噬途径在癌症、发育、胞质分裂、细胞内和细胞间的作用 细胞信号传导、免疫、代谢、神经变性和其他神经元疾病。的主要目标 2022年GRC将在致力于阐明分子机制的研究人员之间建立桥梁， 溶酶体生理学方面的研究者一个相关的目标是提高对以下方面的认识和兴趣： 领域之外的溶酶体生物学因此，2022年GRC计划将包括一个 由28位受邀演讲者组成的多元化阵容，支持以前从未参加过的同事 或者在这个研讨会上发表还有一些调查人员已经很多年没有参加会议了 年（例如，>10年），由于他们的研究计划对人类疾病的不断发展的重点;他们 提供了关于应用内溶酶体基础知识的经验库 生理问题的系统。要解决的领域包括内-溶酶体系统的作用， 癌症，病原体（包括病毒）感染，营养感测，代谢控制和信号传导 组织之间的联系。为了获得最新鲜的节目可能，十九个发言人将从提交 摘要和一个完整的会议将专门讨论新的研究方向。将鼓励所有与会者 参加两个海报会议之一。戈登研究研讨会（GRS），仅对毕业生开放 学生和博士后研究人员，将在GRC开始前一天召开。非正式 GRS的氛围使学员能够在培养环境中建立演讲和网络技能。 由于内-溶酶体系统对人体生理学的重要性， 过去溶酶体和内吞戈登研究会议的成功，NCI，NCATS的支持， NIAID、NIA、NICHD以及其他NIH研究所将推进关键投资， 健康和疾病中的溶酶体生物学。

Abstract This application requests partial support for a Gordon Research Conference (GRC) on Lysosomes and Endocytosis at Proctor Academy, Andover, NH from June 19-24, 2022. Support for the associated Gordon Research Seminar (GRS) immediately preceding the GRC (June 18-19) is also requested. The Lysosomes and Endocytosis GRC has a 50+ year tradition as the preeminent scientific venue for investigators of endocytosis and lysosome biology in health and in disease. It is also highly regarded for the high level of communication between colleagues at all career levels, and for the mentorship of junior colleagues. For more than a decade now molecular mechanisms of endocytosis and for targeting of molecules to the lysosome for degradation have been the focus of this GRC. However, the field evolves rapidly, and recent advances indicate roles for the endo-lysosome and autophagy pathways in cancer, development, cytokinesis, intra- and inter- cellular signaling, immunity, metabolism, neurodegeneration and other neuronal diseases. The principal goal of the 2022 GRC is to build bridges between investigators working to elucidate molecular mechanisms and investigators of physiological aspects of the lysosome. A related goal is to raise awareness of and interest in lysosome biology outside of the field proper. Accordingly, the 2022 GRC program will embrace an exceptionally diverse cast of 28 invited speakers, favoring colleagues who have either not previously attended or presented at this GRC. Also featured are investigators who have not attended the conference for many years (e.g., >10 years) due to the evolving emphasis of their research programs on human disease; they provide a reservoir of experience regarding the application of fundamental knowledge of the endo-lysosome system to physiological questions. Areas to be addressed include the roles of the endo-lysosomal system in cancer, pathogen (including viruses) infection, nutrient sensing, the control of metabolism, and signaling between tissues. To attain the freshest program possible, nineteen speakers will be selected from submitted abstracts and one entire session will be devoted to new research directions. All attendees will be encouraged to participate in one of two poster sessions. A Gordon Research Seminar (GRS), open solely to graduate students and postdoctoral researchers, will convene one day prior to the start of the GRC. The informal atmosphere of the GRS allows trainees to build presentation and networking skills in a nurturing environment. Due to the vital importance of the endo-lysosomal system to human physiology, and the exceptional record of success of past Lysosomes and Endocytosis Gordon Research Conferences, the support of the NCI, NCATS, NIAID, NIA, NICHD, as well as other NIH institutes, will advance critical investments toward understanding lysosome biology in health and disease.