2022 Lysosomes & Endocytosis Gordon Research Conference and Gordon Research Seminar

摘要 此应用程序请求部分支持戈登研究会议(GRC)的溶酶体和 2022年6月19日至24日，NH，Andover，Proctor Academy的内吞作用。支持关联的Gordon 还要求在GRC(6月18日至19日)之前立即举办研究研讨会(GRS)。溶酶体 和内吞作用GRC有50年的传统，作为研究人员的卓越科学场所 健康和疾病中的内吞作用和溶酶体生物学。它也因其高水平的 在所有职业级别的同事之间进行沟通，并为初级同事提供指导。了解更多 十多年来，内吞作用的分子机制和分子靶向溶酶体的作用 退化一直是GRC关注的焦点。然而，该领域发展迅速，最近的进展表明 内切溶酶体和自噬途径在癌症发生、胞质分裂、细胞内和细胞间的作用 细胞信号、免疫、代谢、神经变性等神经性疾病。的主要目标是 2022年GRC将在致力于阐明分子机制的研究人员和 溶酶体生理方面的研究人员。一个相关的目标是提高人们对 场外的溶酶体生物学。因此，2022年GRC计划将包含一个 由28位受邀演讲者组成的异常多样化的演员阵容，倾向于以前没有出席过的同事 或在这个GRC上展示。参加会议的还有许多年没有参加会议的调查人员。 几年(例如，&gt；10年)，因为他们的研究计划对人类疾病的重视不断变化；他们 提供关于应用内切溶酶体基本知识的经验宝库 系统对生理问题的反应。有待解决的领域包括内切溶酶体系统在 癌症、病原体(包括病毒)感染、营养感应、新陈代谢控制和信号传递 在纸巾之间。为了获得尽可能新鲜的节目，将从提交的19位演讲者中挑选出 摘要和整个会议将致力于新的研究方向。所有与会者都将受到鼓励 参加两个海报会议中的一个。戈登研究研讨会(GRS)，仅对毕业生开放 学生和博士后研究人员将在GRC开始前一天开会。非正式的 GRS的氛围允许学员在培育环境中培养演示和网络技能。 由于内切溶酶体系统对人类生理学的至关重要，以及 过去溶酶体和内吞戈登研究会议的成功，NCI，NCATS， NIAID、NIA、NICHD以及其他NIH研究所将推进关键投资，使人们了解 健康与疾病中的溶酶体生物学。

Abstract This application requests partial support for a Gordon Research Conference (GRC) on Lysosomes and Endocytosis at Proctor Academy, Andover, NH from June 19-24, 2022. Support for the associated Gordon Research Seminar (GRS) immediately preceding the GRC (June 18-19) is also requested. The Lysosomes and Endocytosis GRC has a 50+ year tradition as the preeminent scientific venue for investigators of endocytosis and lysosome biology in health and in disease. It is also highly regarded for the high level of communication between colleagues at all career levels, and for the mentorship of junior colleagues. For more than a decade now molecular mechanisms of endocytosis and for targeting of molecules to the lysosome for degradation have been the focus of this GRC. However, the field evolves rapidly, and recent advances indicate roles for the endo-lysosome and autophagy pathways in cancer, development, cytokinesis, intra- and inter- cellular signaling, immunity, metabolism, neurodegeneration and other neuronal diseases. The principal goal of the 2022 GRC is to build bridges between investigators working to elucidate molecular mechanisms and investigators of physiological aspects of the lysosome. A related goal is to raise awareness of and interest in lysosome biology outside of the field proper. Accordingly, the 2022 GRC program will embrace an exceptionally diverse cast of 28 invited speakers, favoring colleagues who have either not previously attended or presented at this GRC. Also featured are investigators who have not attended the conference for many years (e.g., >10 years) due to the evolving emphasis of their research programs on human disease; they provide a reservoir of experience regarding the application of fundamental knowledge of the endo-lysosome system to physiological questions. Areas to be addressed include the roles of the endo-lysosomal system in cancer, pathogen (including viruses) infection, nutrient sensing, the control of metabolism, and signaling between tissues. To attain the freshest program possible, nineteen speakers will be selected from submitted abstracts and one entire session will be devoted to new research directions. All attendees will be encouraged to participate in one of two poster sessions. A Gordon Research Seminar (GRS), open solely to graduate students and postdoctoral researchers, will convene one day prior to the start of the GRC. The informal atmosphere of the GRS allows trainees to build presentation and networking skills in a nurturing environment. Due to the vital importance of the endo-lysosomal system to human physiology, and the exceptional record of success of past Lysosomes and Endocytosis Gordon Research Conferences, the support of the NCI, NCATS, NIAID, NIA, NICHD, as well as other NIH institutes, will advance critical investments toward understanding lysosome biology in health and disease.