The Role of Hippocampal Theta Phase in Human Memory Encoding

项目摘要摘要 情节记忆依赖于海马体，被认为涉及其节律性神经活动在 Theta频段(大约3-8赫兹)。啮齿类动物海马theta振荡的时相是 认为确定海马体处理是否优化了记忆编码而不是提取 偏向的信息流入和流出海马体。然而，无论是theta相依性，还是 Theta能力和记忆力之间的关系已经在人类身上得到了充分的测试。这项研究和 训练计划旨在通过实验测试人类受试者的记忆来解决这个问题 允许直接记录海马体节律的神经外科手术。具体地说，这些 实验将在成年癫痫患者身上进行，这些患者正在接受临床上必要的侵入性治疗。 电生理记录。一种新的记忆范式将被用来确定 测量海马theta振荡的相位角和功率与特定记忆的成功 对事件进行编码。接下来，我们将直接测试海马theta功率和相位在记忆中的作用 使用直接电刺激进行编码。刺激将被传递到海马网，以便 牵扯到theta振荡。然后我们将评估这种操作对记忆编码能力的影响。 这些发现可能会提高对海马神经学习和记忆机制的理解，并提供 记忆障碍的治疗。这项研究将为申请人，一名寻求博士学位的学生提供 神经科学，在复杂的认知神经科学实验中使用人类记忆 侵入性电生理学方法。这一学习经验将得到相关课程的补充， 研究设计和方法、分析、口头和书面科学方面的研讨会和辅导 沟通，和职业发展。

Project Summary Abstract Episodic memory depends on the hippocampus and is thought to involve its rhythmic neural activity in the theta-frequency band (approximately 3-8 Hz). The phase of the hippocampal theta oscillation in rodents is thought to determine whether hippocampal processing is optimized for memory encoding versus retrieval by biasing information flow in versus out of the hippocampus. However, neither the theta phase-dependence nor the relationship between theta power and memory have been adequately tested in humans. This research and training plan aims to address this by experimentally testing memory in human subjects undergoing neurosurgical procedures that allow for direct recording of the hippocampal theta rhythm. Specifically, these experiments will be performed in adults with epilepsy who are undergoing clinically necessary invasive electrophysiological recording. A novel memory paradigm will be used to identify the relationship between measured phase angles and power of the hippocampal theta oscillation and the success of specific memory encoding events. Next, we will directly test the role of hippocampal theta power and phase in memory encoding using direct electrical stimulation. Stimulation will be delivered to the hippocampal network in order to entrain the theta oscillation. We will then assess the impact of this manipulation on memory encoding ability. Findings may improve understanding of hippocampal neural mechanisms for learning and memory and inform treatment of memory disorders. This research will provide the applicant, a student seeking a Ph.D. in neuroscience, with training in sophisticated cognitive neuroscience experimentation on human memory using invasive electrophysiology methods. This learning experience will be complemented by relevant coursework, workshops, and mentored instruction in research design and methods, analytics, oral and written scientific communication, and professional development.