Novel Methods for Evaluating the Association of Electronic Cigarette Use with Cardiovascular Health

评估电子烟使用与心血管健康关联的新方法

• 批准号: 10462491
• 负责人: Andrew Stokes
• 金额: $ 17.83万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10462491
• 关键词: Abstinence; Acute; Adult; Aerosols; Applications Grants; Aromatic Polycyclic Hydrocarbons; Behavior; Biological Markers; Biometry; Blood Pressure; Cardiovascular system; Characteristics; Cholesterol; Cigar; Cigarette; Clinical; Clinical Sciences; Consequentialism; Coronary heart disease; Data; Data Science; Data Set; Development; Diagnosis; Electronic cigarette; Etiology; Event; Family; Frequencies; Funding; Future; Goals; Health; Health Professional; Heart failure; In Vitro; Inflammation; Institutes; Intervention; Knowledge; Label; Link; Long-Term Effects; Measures; Mediating; Mediation; Mediator of activation protein; Mentored Research Scientist Development Award; Mentors; Mentorship; Metals; Methods; Modeling; Myocardial Infarction; National Health and Nutrition Examination Survey; Nicotine; Nitrosamines; Outcome; Oxidative Stress; Patient Self-Report; Pattern; Policies; Population; Population Assessment of Tobacco and Health; Population Research; Probability; Program Development; Prospective cohort study; Randomized Controlled Trials; Research; Research Personnel; Residual state; Risk; Risk Factors; Role; Safety; Sample Size; Scientist; Secure; Series; Smokeless Tobacco; Statistical Methods; Stroke; Structural Models; Testing; Thrombosis; Time; Tobacco; Tobacco use; Training; Training Activity; Translational Research; Triglycerides; United States Food and Drug Administration; United States National Institutes of Health; Work; base; biomarker signature; cardiovascular disorder epidemiology; cardiovascular effects; cardiovascular health; cardiovascular injury; cardiovascular risk factor; career; cigarette smoking; cigarillos; design; e-cigarette aerosols; early-career faculty; electronic cigarette use; evidence base; high risk population; in vivo; innovation; multidisciplinary; non-cigarette tobacco product; novel; population based; population health; pre-clinical; programs; public health intervention; skills; tobacco products; tobacco regulatory science; urinary; volatile organic compound

Project Summary This proposed 5-year study brings together Dr. Stokes’ training in population health and research on tobacco use behaviors with additional training in tobacco regulatory science, cardiovascular (CV) epidemiology, advanced biostatistics, and applied data science. To this end, Dr. Stokes has assembled a multidisciplinary team of mentors and advisors to aid his training and studies. The K01 will support a complementary set of training activities, including formal coursework, participation in the Early Career Faculty Development Program, the NIH-funded Clinical and Translational Science Institute sponsored K-to-R PRIME program, and strong mentorship from experts in relevant fields, to help him in his professional development and transition to independence. Population-based evidence on the CV effects of e-cigarette use is sparse, and the particular components of e-cigarette aerosols that may be responsible for CV harm remain poorly elucidated. The proposed research will integrate state-of-the-art causal inference methods, mediation analyses, and unsupervised data clustering approaches with the study of CV effects of e-cigarette use. The applicant will 1) examine the association of e-cigarette use and product transitions with incident CV events; 2) estimate associations of e-cigarette use with risk factors and preclinical biomarkers of CV injury, and analyze biomarkers of exposure as potential mediators; and 3) identify unique biomarker signatures of e-cigarette exposure using a data-driven clustering approach, and associate clusters with preclinical biomarkers of CV injury. With high quality population data and novel statistical methods to optimally control for cigarette smoking and other tobacco product use, the results of this project will provide timely and rigorous evidence on the CV effects of e-cigarette use. Together with evaluating the mediating role of exposure biomarkers and clustered e- cigarette use behavior patterns, the results will inform Food and Drug Administration regulatory standards for product safety and guide primary and secondary public health interventions that aim to reduce tobacco-related CV harm. The methods and findings will also inform future studies focused on other non-cigarette tobacco products, such as little cigars, cigarillos, and smokeless tobacco products. The additional training and protected time afforded by the K01 will aid Dr. Stokes in making his transition to an independent investigator capable of securing R-series NIH funding.

项目摘要 这项5年的研究汇集了Stokes博士在人口健康方面的培训和研究烟草研究 在烟草监管科学，心血管（CV）流行病学中使用其他培训的行为， 高级生物统计学和应用数据科学。为此，斯托克斯博士汇集了一个多学科 导师和顾问团队，以帮助他的培训和学习。 K01将支持一组完整的 培训活动，包括正式课程，参加早期职业教师发展计划， NIH资助的临床和转化科学学院赞助了K-TO-R PRIME计划，并且很强大 从相关领域的专家统治，以帮助他的专业发展和过渡到 独立。基于人群的有关电子烟的CV效应的证据很少，并且特定的 可能导致CV危害的电子烟气雾剂的组件仍然阐明。这 拟议的研究将整合最新的因果推断方法，调解分析和 无监督的数据聚类方法研究了使用电子烟的CV效应。申请人将1） 检查电子烟的使用和产品过渡与事件简历事件的关联； 2）估计 电子烟的使用与危险因素和简历损伤的临床前生物标志物的关联，并分析 接触的生物标志物作为潜在的介体； 3）确定电子烟的独特生物标志物特征 使用数据驱动的聚类方法暴露，并将簇与CV的临床前生物标志物相关联 受伤。具有高质量的人口数据和新颖的统计方法，可最佳地控制吸烟 以及其他烟草产品的使用，该项目的结果将在简历上及时，严格的证据 电子烟的影响。以及评估暴露生物标志物和聚类e-的中介作用 香烟使用行为方式，结果将为食品和药物管理局的监管标准提供信息 产品安全和指导初级和二级公共卫生干预措施，旨在减少与烟草有关的 简历危害。这些方法和发现还将为未来的研究提供信息，该研究的重点是其他非二烟烟草 产品，例如小雪茄，雪茄和无烟烟草产品。额外的培训和 K01提供的保护时间将有助于Stokes博士过渡到独立调查员 能够获得R系列NIH资金。