Novel Methods for Evaluating the Association of Electronic Cigarette Use with Cardiovascular Health
评估电子烟使用与心血管健康关联的新方法
基本信息
- 批准号:10689206
- 负责人:
- 金额:$ 17.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AbstinenceAcuteAdultAerosolsApplications GrantsAromatic Polycyclic HydrocarbonsBehaviorBiological MarkersBiometryBlood PressureCardiovascular systemCharacteristicsCholesterolCigarCigaretteClinicalClinical SciencesCoronary heart diseaseDataData ScienceData SetDevelopmentDiagnosisElectronic cigaretteEtiologyEventFamilyFrequenciesFundingFutureGoalsHealthHealth ProfessionalHeart failureIn VitroInflammationInterventionKnowledgeLabelLinkLong-Term EffectsMarketingMeasuresMediatingMediationMediatorMentored Research Scientist Development AwardMentorsMentorshipMetalsMethodsModelingMyocardial InfarctionNational Health and Nutrition Examination SurveyNicotineNitrosaminesOutcomeOxidative StressPatient Self-ReportPatternPoliciesPopulationPopulation Assessment of Tobacco and HealthPopulation ResearchProbabilityProgram DevelopmentProspective, cohort studyRandomized, Controlled TrialsResearchResearch PersonnelResidual stateRiskRisk FactorsRoleSafetySample SizeScientistSecureSeriesSmokeless TobaccoStatistical MethodsStrokeStructural ModelsTestingThrombosisTimeTobaccoTobacco useTrainingTraining ActivityTranslational ResearchTriglyceridesUnited States Food and Drug AdministrationUnited States National Institutes of HealthWorkbiomarker signaturecardiovascular disorder epidemiologycardiovascular effectscardiovascular healthcardiovascular injurycardiovascular risk factorcareercigarette smokingcigarillosdesigne-cigarette aerosolsearly-career facultyelectronic cigarette useevidence basehigh risk populationin vivoinnovationmultidisciplinarynon-cigarette tobacco productnovelpopulation basedpopulation healthpre-clinicalprogramspublic health interventionskillstobacco productstobacco regulatory scienceurinaryvolatile organic compound
项目摘要
Project Summary
This proposed 5-year study brings together Dr. Stokes’ training in population health and research on tobacco
use behaviors with additional training in tobacco regulatory science, cardiovascular (CV) epidemiology,
advanced biostatistics, and applied data science. To this end, Dr. Stokes has assembled a multidisciplinary
team of mentors and advisors to aid his training and studies. The K01 will support a complementary set of
training activities, including formal coursework, participation in the Early Career Faculty Development Program,
the NIH-funded Clinical and Translational Science Institute sponsored K-to-R PRIME program, and strong
mentorship from experts in relevant fields, to help him in his professional development and transition to
independence. Population-based evidence on the CV effects of e-cigarette use is sparse, and the particular
components of e-cigarette aerosols that may be responsible for CV harm remain poorly elucidated. The
proposed research will integrate state-of-the-art causal inference methods, mediation analyses, and
unsupervised data clustering approaches with the study of CV effects of e-cigarette use. The applicant will 1)
examine the association of e-cigarette use and product transitions with incident CV events; 2) estimate
associations of e-cigarette use with risk factors and preclinical biomarkers of CV injury, and analyze
biomarkers of exposure as potential mediators; and 3) identify unique biomarker signatures of e-cigarette
exposure using a data-driven clustering approach, and associate clusters with preclinical biomarkers of CV
injury. With high quality population data and novel statistical methods to optimally control for cigarette smoking
and other tobacco product use, the results of this project will provide timely and rigorous evidence on the CV
effects of e-cigarette use. Together with evaluating the mediating role of exposure biomarkers and clustered e-
cigarette use behavior patterns, the results will inform Food and Drug Administration regulatory standards for
product safety and guide primary and secondary public health interventions that aim to reduce tobacco-related
CV harm. The methods and findings will also inform future studies focused on other non-cigarette tobacco
products, such as little cigars, cigarillos, and smokeless tobacco products. The additional training and
protected time afforded by the K01 will aid Dr. Stokes in making his transition to an independent investigator
capable of securing R-series NIH funding.
项目摘要
这项拟议的5年研究将斯托克斯博士在人口健康方面的培训和对烟草的研究结合起来
在烟草监管科学,心血管(CV)流行病学,
高级生物统计学和应用数据科学。为此,斯托克斯博士组建了一个多学科的
一个导师和顾问团队,以帮助他的培训和学习。K 01将支持一套互补的
培训活动,包括正式课程,参加早期职业教师发展计划,
NIH资助的临床和转化科学研究所赞助了K-to-R PRIME项目,
相关领域专家的指导,以帮助他在专业发展和过渡到
独立关于电子烟使用对CV影响的基于人群的证据很少,
电子烟气溶胶中可能导致心血管损害的成分仍不清楚。的
拟议的研究将整合最先进的因果推理方法,调解分析,
无监督的数据聚类方法与电子烟使用的CV影响的研究。申请人将1)
检查电子烟使用和产品转换与CV事件的关联; 2)估计
电子烟使用与CV损伤的风险因素和临床前生物标志物的相关性,并分析
暴露的生物标志物作为潜在的介质;以及3)识别电子烟的独特生物标志物特征
使用数据驱动的聚类方法,将聚类与CV的临床前生物标志物相关联
损伤利用高质量的人口数据和新颖的统计方法来优化控制吸烟
和其他烟草制品的使用,本项目的结果将提供及时和严格的证据,
电子烟使用的影响。同时评估暴露生物标志物和聚集的e-
香烟使用行为模式,结果将告知食品和药物管理局的监管标准,
产品安全和指导旨在减少烟草相关的初级和二级公共卫生干预措施
心血管损害。这些方法和发现也将为未来针对其他非卷烟烟草的研究提供信息。
小雪茄、小雪茄和无烟烟草产品。额外的培训和
K 01提供的受保护的时间将有助于斯托克斯博士过渡到独立调查员
能够获得R系列NIH资助
项目成果
期刊论文数量(18)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Association of device type, flavours and vaping behaviour with tobacco product transitions among adult electronic cigarette users in the USA.
- DOI:10.1136/tobaccocontrol-2020-055999
- 发表时间:2022-08
- 期刊:
- 影响因子:5.2
- 作者:Harlow AF;Fetterman JL;Ross CS;Robertson RM;Bhatnagar A;Benjamin EJ;Stokes AC
- 通讯作者:Stokes AC
Motivations for E-cigarette use and associations with vaping frequency and smoking abstinence among adults who smoke cigarettes in the United States.
- DOI:10.1016/j.drugalcdep.2022.109583
- 发表时间:2022-09-01
- 期刊:
- 影响因子:4.2
- 作者:Harlow, Alyssa F.;Cho, Junhan;Tackett, Alayna P.;McConnell, Rob S.;Leventhal, Adam M.;Stokes, Andrew C.;Barrington-Trimis, Jessica L.
- 通讯作者:Barrington-Trimis, Jessica L.
E-cigarette, cigarette, and cannabis use patterns as a function of sexual identity in a sample of Southern California young adults.
- DOI:10.1016/j.abrep.2021.100338
- 发表时间:2021-06
- 期刊:
- 影响因子:0
- 作者:Liautaud MM;Barrington-Trimis JL;Liu F;Stokes A;Krueger EA;McConnell R;Pang RD
- 通讯作者:Pang RD
Assessment of Patterns in e-Cigarette Use Among Adults in the US, 2017-2020.
- DOI:10.1001/jamanetworkopen.2022.23266
- 发表时间:2022-07-01
- 期刊:
- 影响因子:13.8
- 作者:Boakye, Ellen;Osuji, Ngozi;Erhabor, John;Obisesan, Olufunmilayo;Osei, Albert D.;Mirbolouk, Mohammadhassan;Stokes, Andrew C.;Dzaye, Omar;El Shahawy, Omar;Hirsch, Glenn A.;Benjamin, Emelia J.;DeFilippis, Andrew P.;Robertson, Rose Marie;Bhatnagar, Aruni;Blaha, Michael J.
- 通讯作者:Blaha, Michael J.
Racial/Ethnic Differences in Associations of Non-cigarette Tobacco Product Use With Subsequent Initiation of Cigarettes in US Youths.
种族/种族差异在非二烟烟草产品的关联中存在,随后在美国青年中启动了香烟。
- DOI:10.1093/ntr/ntaa170
- 发表时间:2021-05-24
- 期刊:
- 影响因子:0
- 作者:Stokes AC;Wilson AE;Lundberg DJ;Xie W;Berry KM;Fetterman JL;Harlow AF;Cozier YC;Barrington-Trimis JL;Sterling KL;Benjamin EJ;Blaha MJ;Hamburg NM;Bhatnagar A;Robertson RM
- 通讯作者:Robertson RM
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Andrew Stokes其他文献
Andrew Stokes的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Andrew Stokes', 18)}}的其他基金
Novel Methods for Evaluating the Association of Electronic Cigarette Use with Cardiovascular Health
评估电子烟使用与心血管健康关联的新方法
- 批准号:
10462491 - 财政年份:2020
- 资助金额:
$ 17.98万 - 项目类别:
Novel Methods for Evaluating the Association of Electronic Cigarette Use with Cardiovascular Health
评估电子烟使用与心血管健康关联的新方法
- 批准号:
10054421 - 财政年份:2020
- 资助金额:
$ 17.98万 - 项目类别:
Novel Methods for Evaluating the Association of Electronic Cigarette Use with Cardiovascular Health
评估电子烟使用与心血管健康关联的新方法
- 批准号:
10227805 - 财政年份:2020
- 资助金额:
$ 17.98万 - 项目类别:
相似海外基金
Un/kindness, shame & resistance: the care of inpatients in NHS adult acute mental health units and how it might be improved
Un/善良,羞耻
- 批准号:
2885806 - 财政年份:2023
- 资助金额:
$ 17.98万 - 项目类别:
Studentship
Post-Acute Care Transitions for Older Adult Medicare Beneficiaries with Serious Mental Illness
患有严重精神疾病的老年医疗保险受益人的急性后护理过渡
- 批准号:
10772386 - 财政年份:2023
- 资助金额:
$ 17.98万 - 项目类别:
Paving The Way to a Canadian Standard of Care with CAR-T Cellular Therapy: Phase II Trial of CD19 CAR-T for Relapsed/Refractory Adult Acute Lymphoblastic Leukemia (CLIC-01A)
通过 CAR-T 细胞疗法为加拿大护理标准铺平道路:CD19 CAR-T 治疗复发/难治性成人急性淋巴细胞白血病的 II 期试验 (CLIC-01A)
- 批准号:
474619 - 财政年份:2022
- 资助金额:
$ 17.98万 - 项目类别:
Operating Grants
Investigating the impact acute inhalation of cannabis with a high content of delta-9-tetrahydrocannabinol has on myelination and microglia in adult and aged mice
研究急性吸入高含量 delta-9-四氢大麻酚的大麻对成年和老年小鼠髓鞘形成和小胶质细胞的影响
- 批准号:
485965 - 财政年份:2022
- 资助金额:
$ 17.98万 - 项目类别:
Studentship Programs
Paving The Way to a Canadian Standard of Care with CAR-T Cellular Therapy: Phase II Trial of CD19 CAR-T for Relapsed/Refractory Adult Acute Lymphoblastic Leukemia (CLIC-01A)
通过 CAR-T 细胞疗法为加拿大护理标准铺平道路:CD19 CAR-T 治疗复发/难治性成人急性淋巴细胞白血病的 II 期试验 (CLIC-01A)
- 批准号:
466358 - 财政年份:2022
- 资助金额:
$ 17.98万 - 项目类别:
Operating Grants
Metabolomics for prediction of cisplatin mediated acute kidney injury: a Canadian multi-centre adult and pediatric study
预测顺铂介导的急性肾损伤的代谢组学:加拿大多中心成人和儿童研究
- 批准号:
402040 - 财政年份:2019
- 资助金额:
$ 17.98万 - 项目类别:
Operating Grants
Study of pathogenic mechanism of age-dependent chromosome translocation in adult acute lymphoblastic leukemia
成人急性淋巴细胞白血病年龄依赖性染色体易位发病机制研究
- 批准号:
18K16103 - 财政年份:2018
- 资助金额:
$ 17.98万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Causal effect of time-varying driving pressures on mortality in mechanically ventilated, adult patients with acute respiratory distress syndrome
时变驱动压力对机械通气成年急性呼吸窘迫综合征患者死亡率的因果影响
- 批准号:
377313 - 财政年份:2017
- 资助金额:
$ 17.98万 - 项目类别:
Studentship Programs
Role of SETBP1 in adult Ph+ acute lymphoblastic leukemia
SETBP1 在成人 Ph 急性淋巴细胞白血病中的作用
- 批准号:
9315111 - 财政年份:2016
- 资助金额:
$ 17.98万 - 项目类别:
Acute Inhibition of Adult-born Granule Cells and its Effect on Antidepressant Act
成体颗粒细胞的急性抑制及其抗抑郁作用
- 批准号:
8734273 - 财政年份:2013
- 资助金额:
$ 17.98万 - 项目类别: