Clinical Orthopaedic and Musculoskeletal Education and Training Program (COMET)

肌肉骨骼（MSK）和骨科疾病是惊人的普遍，致残，昂贵，会计 占美国国内生产总值的5%左右。COMET（临床矫形和肌肉骨骼） 教育和培训）T32培训计划的重点是培训临床研究人员，以解决 越来越多的国家和全球MSK疾病的负担通过严格的临床研究。COMET计划 在其第一个十年非常成功;其25名毕业生中有21人留在学术岗位， 8次获得职业发展奖（5次K级奖和3次流变学研究基金会职业发展奖 发展奖）和5个R级赠款（3个R 01和2个R21）。这25名毕业生发表了112篇 基于他们的T32资助工作的同行评审论文。近70%的现任和前任学员是女性 3人属于代表性不足的少数群体。 在这次竞争性更新重新提交中，我们提出了6项研究培训的计划重点 代表紧迫的研究需求并利用教师优势的浓度：锻炼和 体力活动;整形外科手术结果;创新性非药物试验;基于价值的护理;工作 和MSK障碍;以及资源有限环境中的MSK健康。受训者将讨论这些问题和相关研究 主题涉及广泛的MSK和骨科疾病，包括骨关节炎，骨质疏松症， 局部疾病（脊柱、膝关节、肩关节、上肢、足/踝关节）、骨科创伤、关节和软组织 问题，神经卡压，慢性疼痛和相关疾病。通过他们的彗星训练，年轻的 研究人员获得生物统计学和流行病学沿着与一系列其他学科的关键技能 基于他们的职业兴趣（例如行为科学，经济分析，临床试验）。没有 在这些方法学的正式教学培训之前，获得临床有效性硕士学位 在哈佛大学的项目。公共卫生学院。Jeffrey Katz和Elena Losina博士指导了 COMET计划，并由经验丰富，富有成效和协作的教师团队提供支持 来自整个哈佛医学和公共卫生界的导师。该申请要求提供资金 每年提供两个博士前和三个博士后培训职位。此更新重新提交申请 建立在该计划第一个十年成功的基础上，并由总体目标驱动 促进研究，以提高人的生活质量与衰弱MSK障碍。

Musculoskeletal (MSK) and orthopaedic disorders are staggeringly prevalent, disabling, and costly, accounting for ~5% of gross domestic product in the US. The COMET (Clinical Orthopaedic and Musculoskeletal Education and Training) T32 training program is focused on training clinical researchers to address the growing national and global burden of MSK disorders through rigorous clinical research. The COMET program has been highly successful in its first decade; 21 of its 25 graduates have remained in academic positions, with 8 receiving career development awards (5 K-level awards and 3 Rheumatology Research Foundation career development awards), and 5 R-level grants (3 R01s and 2 R21s). These 25 graduates have published 112 peer-reviewed papers based on their T32-funded work. Nearly 70% of current and former trainees are women and 3 belong to underrepresented minority groups. In this competitive renewal resubmission, we propose a programmatic focus on 6 research training concentrations that represent pressing research needs and draw on the strengths of the faculty: exercise and physical activity; orthopedic surgical outcomes; innovative non-pharmacologic trials; value-based care; work and MSK disorders; and MSK health in resource-limited settings. Trainees address these and related research themes in relation to a broad range of MSK and orthopaedic disorders, including osteoarthritis, osteoporosis, regional disorders (spine, knee, shoulder, upper extremity, foot/ankle), orthopaedic trauma, joint and soft tissue problems, nerve entrapments, chronic pain, and related conditions. Through their COMET training, young investigators acquire critical skills in biostatistics and epidemiology along with a range of other disciplines based on their career interests (e.g. behavioral science, economic analysis, clinical trials). Trainees without prior formal didactic training in these methodologies obtain a master's degree in the Clinical Effectiveness Program at the Harvard T.H. Chan School of Public Health. Drs. Jeffrey Katz and Elena Losina direct the COMET program and are supported by a highly experienced, productive, and collaborative group of faculty mentors from throughout the Harvard medical and public health communities. This application requests funding for two predoctoral and three postdoctoral training positions per year. This renewal resubmission application builds upon a foundation of success over the first decade of the program and is driven by the overarching goal of facilitating research to improve the quality of life of persons with debilitating MSK disorders.